Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Chad L. Myers"'
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-6 (2024)
Externí odkaz:
https://doaj.org/article/841c9ff064044d298b8ff2de69357987
Autor:
Emily H. Xiong, Xiang Zhang, Huijuan Yan, Henry N. Ward, Zhen-Yuan Lin, Cassandra J. Wong, Ci Fu, Anne-Claude Gingras, Suzanne M. Noble, Nicole Robbins, Chad L. Myers, Leah E. Cowen
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114601- (2024)
Summary: Fungal pathogens such as Candida albicans pose a significant threat to human health with limited treatment options available. One strategy to expand the therapeutic target space is to identify genes important for pathogen growth in host-rele
Externí odkaz:
https://doaj.org/article/7a90d14f55eb4540a12239260d52e408
Autor:
Kevin Lin, Ya-Chu Chang, Maximilian Billmann, Henry N. Ward, Khoi Le, Arshia Z. Hassan, Urvi Bhojoo, Katherine Chan, Michael Costanzo, Jason Moffat, Charles Boone, Anja-Katrin Bielinsky, Chad L. Myers
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Current approaches to define chemical-genetic interactions (CGIs) in human cell lines are resource-intensive. We designed a scalable chemical-genetic screening platform by generating a DNA damage response (DDR)-focused custom sgRNA library t
Externí odkaz:
https://doaj.org/article/3b9ce5f7b8554685b2e0afb2fc4f3cce
Autor:
Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles Boone, Rui Gonçalo Martinho, Thomas Arnesen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-termina
Externí odkaz:
https://doaj.org/article/d00c6a73922e4ae69223e5ddad630fd5
Autor:
Ya-Chu Chang, Kevin Lin, Ryan M. Baxley, Wesley Durrett, Liangjun Wang, Olivera Stojkova, Maximilian Billmann, Henry Ward, Chad L. Myers, Anja-Katrin Bielinsky
Publikováno v:
Open Biology, Vol 13, Iss 8 (2023)
DNA replication requires precise regulation achieved through post-translational modifications, including ubiquitination and SUMOylation. These modifications are linked by the SUMO-targeted E3 ubiquitin ligases (STUbLs). Ring finger protein 4 (RNF4),
Externí odkaz:
https://doaj.org/article/fc25571c38be441b9df006b8d49f3bfe
Autor:
Colette B. Rogers, Rachel E. Kram, Kevin Lin, Chad L. Myers, Alexandra Sobeck, Eric A. Hendrickson, Anja-Katrin Bielinsky
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112428- (2023)
Summary: Activation of the Fanconi anemia (FA) pathway after treatment with mitomycin C (MMC) is essential for preventing chromosome translocations termed “radials.” When replication forks stall at MMC-induced interstrand crosslinks (ICLs), the F
Externí odkaz:
https://doaj.org/article/0757e35807f24fbaae71831f4c22df5d
Autor:
Brian W. Diers, James E. Specht, George L. Graef, Qijian Song, Katy Martin Rainey, Vishnu Ramasubramanian, Xiaotong Liu, Chad L. Myers, Robert M. Stupar, Yong‐Qiang Charles An, William D. Beavis
Publikováno v:
The Plant Genome, Vol 16, Iss 1, Pp n/a-n/a (2023)
Abstract Soybean is grown primarily for the protein and oil extracted from its seed and its value is influenced by these components. The objective of this study was to map marker‐trait associations (MTAs) for the concentration of seed protein, oil,
Externí odkaz:
https://doaj.org/article/6f1d726d973d4bd987cfab4b618a61f6
Autor:
Willow Coyote-Maestas, David Nedrud, Antonio Suma, Yungui He, Kenneth A. Matreyek, Douglas M. Fowler, Vincenzo Carnevale, Chad L. Myers, Daniel Schmidt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Here, the authors perform a large-scale, high-throughput biochemical assay to determine the compatibility of over 300,000 domain recombination variants of the inward rectifier K+ channel Kir2.1. They derive rules for designing domain insertion varian
Externí odkaz:
https://doaj.org/article/446c0c0118e64afe931272b243499af9
Autor:
Ci Fu, Xiang Zhang, Amanda O. Veri, Kali R. Iyer, Emma Lash, Alice Xue, Huijuan Yan, Nicole M. Revie, Cassandra Wong, Zhen-Yuan Lin, Elizabeth J. Polvi, Sean D. Liston, Benjamin VanderSluis, Jing Hou, Yoko Yashiroda, Anne-Claude Gingras, Charles Boone, Teresa R. O’Meara, Matthew J. O’Meara, Suzanne Noble, Nicole Robbins, Chad L. Myers, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The analysis of essential genes in pathogens can be used to discover potential antimicrobial targets. Here, the authors use a machine learning model and chemogenomic analyses to generate genome-wide gene essentiality predictions for the fungal pathog
Externí odkaz:
https://doaj.org/article/30b53e35a0bc440e930c93cb62d5cbf8
Autor:
Kevin Lin, Ya-Chu Chang, Ezequiel Marron Fernandez de Velasco, Kevin Wickman, Chad L. Myers, Anja-Katrin Bielinsky
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101675- (2022)
Summary: Pooled lentiviral CRISPR-Cas9 screens are utilized for assessing the differential sensitivity or resistance of many single-gene knockouts to a compound. Here, we present a scalable approach for high-throughput compound screening by utilizing
Externí odkaz:
https://doaj.org/article/954cde00cbfd4802acf251d0cbe0cfb8