Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Chad K Heazlewood"'
Autor:
Chad K Heazlewood, Matthew C Cook, Rajaraman Eri, Gareth R Price, Sharyn B Tauro, Douglas Taupin, David J Thornton, Chin Wen Png, Tanya L Crockford, Richard J Cornall, Rachel Adams, Masato Kato, Keats A Nelms, Nancy A Hong, Timothy H J Florin, Christopher C Goodnow, Michael A McGuckin
Publikováno v:
PLoS Medicine, Vol 5, Iss 3, p e54 (2008)
MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains ob
Externí odkaz:
https://doaj.org/article/af62c4dfb9b94eb5a0ffff5247810ccf
Autor:
Shen Y. Heazlewood, Tanveer Ahmad, Benjamin Cao, Huimin Cao, Melanie Domingues, Xuan Sun, Chad K. Heazlewood, Songhui Li, Brenda Williams, Madeline Fulton, Jacinta F. White, Tom Nebl, Christian M. Nefzger, Jose M. Polo, Benjamin T. Kile, Felix Kraus, Michael T. Ryan, Yu B. Sun, Peter F. M. Choong, Sarah L. Ellis, Minna-Liisa Anko, Susan K. Nilsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Megakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic megakaryocytes (LCM) are critical negative regulators of HSC and criti
Externí odkaz:
https://doaj.org/article/7defb2ab48b547d0b668ad9675392191
Autor:
Xuan Sun, Benjamin Cao, Marina Naval-Sanchez, Tony Pham, Yu Bo Yang Sun, Brenda Williams, Shen Y. Heazlewood, Nikita Deshpande, Jinhua Li, Felix Kraus, James Rae, Quan Nguyen, Hamed Yari, Jan Schröder, Chad K. Heazlewood, Madeline Fulton, Jessica Hatwell-Humble, Kaustav Das Gupta, Ronan Kapetanovic, Xiaoli Chen, Matthew J. Sweet, Robert G. Parton, Michael T. Ryan, Jose M. Polo, Christian M. Nefzger, Susan K. Nilsson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Aged hematopoietic stem cells (HSC) are characterised by reduced regenerative potential and a loss of quiescence. Here, the authors show nicotinamide riboside treatment shrinks the age-enlarged stem cell pool and shifts aged HSC functionally, metabol
Externí odkaz:
https://doaj.org/article/a2cd09ff347c4623848c6acc6789d348
Autor:
Benjamin Cao, Zhen Zhang, Jochen Grassinger, Brenda Williams, Chad K. Heazlewood, Quentin I. Churches, Simon A. James, Songhui Li, Thalia Papayannopoulou, Susan K. Nilsson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem c
Externí odkaz:
https://doaj.org/article/da0cd1920a214e60a77818aaf0b365f2
Autor:
Pradnya Gangatirkar, Brenda Williams, Belinda B. Guo, Benjamin Cao, Sarah Ellis, Chad K Heazlewood, Madeline Fulton, Mirana Ramialison, Jacinta F. White, Emma C. Josefsson, Huimin Cao, Tanveer Ahmad, Shen Y. Heazlewood, Madara Ratnadiwakara, Monika Mohenska, Minna-Liisa Änkö, Susan K. Nilsson
Publikováno v:
Blood. 139(9)
RNA processing is increasingly recognized as a critical control point in the regulation of different hematopoietic lineages including megakaryocytes responsible for the production of platelets. Platelets are anucleate cytoplasts that contain a rich r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093f9189998ce9eab59d2c9b78eba02f
https://pubmed.ncbi.nlm.nih.gov/34852174
https://pubmed.ncbi.nlm.nih.gov/34852174
Autor:
Quan Nguyen, Brenda Williams, Matthew J. Sweet, Xiaoli Chen, Nikita Deshpande, Kaustav Das Gupta, Jose M. Polo, Ronan Kapetanovic, Madeline Fulton, Christian M. Nefzger, Jinhua Li, Susan K. Nilsson, Shen Y. Heazlewood, Robert G. Parton, Jan Schröder, Felix Kraus, Benjamin Cao, Jessica Hatwell-Humble, James Rae, Tony Pham, Chad K. Heazlewood, Hamed Yari, Yu Bo Yang Sun, Michael T. Ryan, Xuan Sun, Marina Naval-Sanchez
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
With age, hematopoietic stem cells (HSC) undergo changes in function, including reduced regenerative potential and loss of quiescence, which is accompanied by a significant expansion of the stem cell pool that can lead to haematological disorders. El
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd2f98e97120260d417fe49aba1a477
https://pubmed.ncbi.nlm.nih.gov/33976125
https://pubmed.ncbi.nlm.nih.gov/33976125
Autor:
Melanie Domingues, Huimin Cao, Emmanuel Debele, Benjamin Cao, Xuan Sun, Susan K. Nilsson, Natalie A. Sims, Narelle E. McGregor, Shen Y. Heazlewood, Chad K. Heazlewood
Publikováno v:
Cells
Volume 8
Issue 9
Cells, Vol 8, Iss 9, p 985 (2019)
Volume 8
Issue 9
Cells, Vol 8, Iss 9, p 985 (2019)
Osteopontin (OPN) is an important component in both bone and blood regulation, functioning as a bridge between the two. Previously, thrombin-cleaved osteopontin (trOPN), the dominant form of OPN in adult bone marrow (BM), was demonstrated to be a cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1c5726345daae2682f99ea4196f73f
https://pubmed.ncbi.nlm.nih.gov/31461896
https://pubmed.ncbi.nlm.nih.gov/31461896
Autor:
Xuan Sun, Christian M. Nefzger, Sabine Iberl, Melanie Domingues, Ines Martin-Padura, Jochen Grassinger, Songhui Li, Andrew Vinson, David N. Haylock, Chad K. Heazlewood, Brenda Williams, Roland Christian Schelker, Gunnar Müller, Shen Y. Heazlewood, Wolfgang Herr, Benjamin Cao, Jose M. Polo, Claire Pritchard, Christina Hart, Susan K. Nilsson
Publikováno v:
Experimental Hematology. 76:S52
Efficient homing of hematopoietic stem cells (HSC) from blood to the bone marrow (BM) following transplant is critical for achieving optimal engraftment. Indeed, HSC mobilized using the growth factor G-CSF are known to have reduced engraftment potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030b352c9149e17048e5391e24de1e46
https://doi.org/10.1016/j.exphem.2019.06.310
https://doi.org/10.1016/j.exphem.2019.06.310
Autor:
Felix Kraus, Tanveer Ahmad, Brenda Williams, Jacinta F. White, Huimin Cao, Madeline Fulton, Minna-Liisa Änkö, Shen Y. Heazlewood, Michael T. Ryan, Chad K. Heazlewood, Melanie Domingues, Benjamin T. Kile, Benjamin Cao, Songhui Li, Susan K. Nilsson
Publikováno v:
Experimental Hematology. 76:S68
Traditionally, megakaryocytes (MK) are known for platelet generation; with their role as regulators of hematopoietic stem cells (HSC) only recently being appreciated. While it is generally accepted high ploidy MK produce platelets, we have now identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46ce5002f81d791cb95060525d00e2a7
https://doi.org/10.1016/j.exphem.2019.06.368
https://doi.org/10.1016/j.exphem.2019.06.368
Autor:
Benjamin Cao, S. Iberl, D. Haylock, Brenda Williams, C. Nefzger, Shen Y. Heazlewood, J. Grassinger, W. Herr, G. Müller, R. Schelker, C. Hart, I. Martin-Padura, S. Li, Chad K. Heazlewood, M. Domingues, A. Vinson, J. Polo, Susan K. Nilsson, X. Sun, C. Pritchard
Publikováno v:
HemaSphere. 3:21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e9ab71422e3a6e3ea7ef865be0daf81
https://doi.org/10.1097/01.hs9.0000558776.86374.3f
https://doi.org/10.1097/01.hs9.0000558776.86374.3f