Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Chad J. Pickens"'
Autor:
Luqia Hou, Mohit Kumar, Priti Anand, Yinhong Chen, Nesrine El-Bizri, Chad J. Pickens, W. Michael Seganish, Sakthivel Sadayappan, Gayathri Swaminath
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Cardiac myosin binding protein-C (cMyBP-C) is an important regulator of sarcomeric function. Reduced phosphorylation of cMyBP-C has been linked to compromised contractility in heart failure patients. Here, we used previously published cMyBP-
Externí odkaz:
https://doaj.org/article/b15ebb87cdaf439295dcec183101f5d9
Autor:
Benjamin F. Mann, Erik L. Regalado, Alexey A. Makarov, Chad J. Pickens, Raffeal Bennett, Imad A. Haidar Ahmad
Publikováno v:
Analytical and Bioanalytical Chemistry. 412:2655-2663
The analysis of complex mixtures of closely related species is quickly becoming a bottleneck in the development of new drug substances, reflecting the ever-increasing complexity of both fundamental biology and the therapeutics used to treat disease.
Autor:
Michael Seganish, Luqia Hou, Sakthivel Sadayappan, Mohit Kumar, Yinhong Chen, Chad J Pickens, Priti Anand, Gayathri Swaminath, Nesrine El-Bizri
Cardiac myosin binding protein-C (cMyBP-C) is an important regulator of sarcomeric function. Although reduced phosphorylation of cMyBP-C has been linked to compromised contractility in heart failure patients, direct modulation of cMyBP-C to myosin us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226ef3701f3b627a49f4b41b4d5428c6
https://doi.org/10.21203/rs.3.rs-955920/v1
https://doi.org/10.21203/rs.3.rs-955920/v1
Autor:
Rebuma Firdessa-Fite, Cory Berkland, Remi J. Creusot, Joshua O Sestak, Chad J. Pickens, Martin A. Leon, Justin K Ruffalo
Publikováno v:
ACS Chem Biol
Type 1 diabetes (T1D) is an autoimmune disorder which develops when insulin-producing, pancreatic beta cells are destroyed by an aberrant immune response. Current therapies for T1D either treat symptoms or cause global immunosuppression, which leave
Autor:
Chad J. Pickens, J. Daniel Griffin, Cory Berkland, Brittany L. Hartwell, Joshua Sestak, Michael Shao, Martin A. Leon, Jean R. Salash
Publikováno v:
Biomacromolecules
Antigen valency plays a fundamental role in directing the nature of an immune response to be stimulatory or tolerogenic. Soluble Antigen Arrays (SAgAs) are an antigen-specific immunotherapy that combats autoimmunity through the multivalent display of
Publikováno v:
Bioconjugate Chemistry. 29:686-701
Interrogating biological systems is often limited by access to biological probes. The emergence of "click chemistry" has revolutionized bioconjugate chemistry by providing facile reaction conditions amenable to both biologic molecules and small molec
Publikováno v:
Biomacromolecules
A pressing need exists for antigen-specific immunotherapies (ASIT) that induce selective tolerance in autoimmune disease while avoiding deleterious global immunosuppression. Multivalent soluble antigen arrays (SAgA(PLP:LABL)), consisting of a hyaluro
Autor:
Songyot Anuchapreeda, Siriporn Okonogi, Chadarat Ampasavate, Cory Berkland, Chad J. Pickens, Singkome Tima
Publikováno v:
Journal of Pharmaceutical Sciences. 105:3645-3657
This study aimed to develop a curcumin (CM) nanoparticle targeted to Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3) protein on the surface of leukemic cells and to evaluate their properties, specificity, cytotoxicity, and inhibitory eff
Autor:
Kevin M. Maloney, Songnian Lin, Fanyu Meng, Lin Yan, Pei Huo, David A. Thaisrivongs, Xiujuan Jia, Chad J. Pickens
Publikováno v:
Analytical and bioanalytical chemistry. 412(2)
Insulin oligosaccharide conjugates hold promise as potential glucose-responsive insulins (GRIs), which can improve the therapeutic index of insulins and mitigate the risk of hypoglycemia. A key challenge for the analytical development of such molecul
Autor:
Melissa M. Pressnall, Cory Berkland, Stephanie N. Johnson, Chad J. Pickens, Bradley P. Sullivan, Martin A. Leon, Matthew A. Christopher, Sharadvi Thati
Publikováno v:
Mol Pharm
Multiple sclerosis represents the world's most common cause of neurological disability in young people and is attributed to a loss of immune tolerance toward proteins of the myelin sheath. Typical treatment options for MS patients involve immunomodul