Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Chad J, Roy"'
Autor:
Brandon J. Beddingfield, Kenneth S. Plante, Jessica A. Plante, Scott C. Weaver, Sarah Bose, Clara Krzykwa, Nicole Chirichella, Rachel K. Redmann, Stephanie Z. Seiler, Jason Dufour, Robert V. Blair, Kathrin Endt, Ariane Volkmann, Nicholas J. Maness, Chad J. Roy
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract MVA-based monovalent eastern equine encephalitis virus (MVA-BN-EEEV) and multivalent western, eastern, and Venezuelan equine encephalitis virus (MVA-BN-WEV) vaccines were evaluated in the cynomolgus macaque aerosol model of EEEV infection. M
Externí odkaz:
https://doaj.org/article/91786bd512c949c98f7c1d156f0d183c
Autor:
Harriet L. Hammond, Chad J. Roy
Publikováno v:
Toxins, Vol 16, Iss 10, p 417 (2024)
Palytoxins are a group of highly potent and structurally complex marine toxins that rank among some of the most toxic substances known to science. Palytoxins are naturally synthesized by a variety of marine organisms, including Palythoa zoanthids, Os
Externí odkaz:
https://doaj.org/article/b7bcac68efa64df4986d0efbbd153262
Autor:
Chad J. Roy, Dylan Ehrbar, Greta Van Slyke, Jennifer Doering, Peter J. Didier, Lara Doyle-Meyers, Oreola Donini, Ellen S. Vitetta, Nicholas J. Mantis
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract Inhalation of the biothreat agent, ricin toxin (RT), provokes a localized inflammatory response associated with pulmonary congestion, edema, neutrophil infiltration, and severe acute respiratory distress. The extreme toxicity of RT is the re
Externí odkaz:
https://doaj.org/article/e4fd9f46d68a4a5da1c829f98a009fc9
Autor:
Alyssa C. Fears, Edith M. Walker, Nicole Chirichella, Nadia Slisarenko, Kristen M. Merino, Nadia Golden, Breanna Picou, Skye Spencer, Kasi E. Russell-Lodrigue, Lara A. Doyle-Meyers, Robert V. Blair, Brandon J. Beddingfield, Nicholas J. Maness, Chad J. Roy, Namita Rout
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
The dynamics of γδ T cell frequencies and functions through the course of SARS-CoV-2 infection in rhesus macaques and African green monkeys reveals that Vδ1 γδ T cells are involved in the early immune response to SARS-CoV-2 infection.
Externí odkaz:
https://doaj.org/article/18520bbe745343c7bc6104e42afbb428
Autor:
Zhen Huang, Lili Zhang, Christopher J. Lyon, Bo Ning, Brady M. Youngquist, Alex Niu, Brandon J. Beddingfield, Nicholas J. Maness, Nakhle S. Saba, Chen-Zhong Li, Chad J. Roy, Tony Y. Hu
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 629-638 (2022)
Mounting evidence indicates that SARS-CoV-2 can infect multiple systemic tissues, but few studies have evaluated SARS-CoV-2 RNA dynamics in multiple specimen types due to their reduced accessibility and diminished performance of RT-qPCR with non-resp
Externí odkaz:
https://doaj.org/article/37331d055e52443da112f8ee0fb7a565
Autor:
Ibolya Rutkai, Meredith G. Mayer, Linh M. Hellmers, Bo Ning, Zhen Huang, Christopher J. Monjure, Carol Coyne, Rachel Silvestri, Nadia Golden, Krystle Hensley, Kristin Chandler, Gabrielle Lehmicke, Gregory J. Bix, Nicholas J. Maness, Kasi Russell-Lodrigue, Tony Y. Hu, Chad J. Roy, Robert V. Blair, Rudolf Bohm, Lara A. Doyle-Meyers, Jay Rappaport, Tracy Fischer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
COVID-19 can result in neurological manifestations and animal models could provide insights into the mechanisms. Here, the authors describe neuroinflammation, microhemorrhages and brain hypoxia in SARS-CoV-2 infected non-human primates, including in
Externí odkaz:
https://doaj.org/article/0c1be27d8686492ebe212a4588149d65
Autor:
Brandon J. Beddingfield, Nicholas J. Maness, Skye Spencer, Jay Rappaport, Pyone Pyone Aye, Kasi Russell-Lodrigue, Lara A. Doyle-Meyers, Robert V. Blair, HongMei Gao, David Montefiori, Chad J. Roy
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSARS-CoV-2 is a respiratory pathogen currently causing a worldwide pandemic, with resulting pathology of differing severity in humans, from mild illness to severe disease and death. The rhesus macaque model of COVID-19 was utilized to eva
Externí odkaz:
https://doaj.org/article/3772dde98cab499297a36830dbf4d85e
Autor:
Edith M. Walker, Kristen M. Merino, Nadia Slisarenko, Brooke F. Grasperge, Smriti Mehra, Chad J. Roy, Deepak Kaushal, Namita Rout
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
BackgroundAlthough BCG vaccine protects infants from tuberculosis (TB), it has limited efficacy in adults against pulmonary TB. Further, HIV coinfection significantly increases the risk of developing active TB. In the lack of defined correlates of pr
Externí odkaz:
https://doaj.org/article/c94f2b062858405cad2a503cc4deffd7
Autor:
David A. Edwards, Bengt Norden, Lorie Karnath, Omar Yaghi, Chad J. Roy, Donald Johanson, Melanie Ott, John Brownstein, John Grove, Goran Tomson, Peter Friberg
Publikováno v:
Molecular Frontiers Journal, Vol 05, Iss 01n02, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/3691bb497abe498cbc7c9e3cf92b875d
Autor:
Alyssa C Fears, Brandon J Beddingfield, Nicole R Chirichella, Nadia Slisarenko, Stephanie Z Killeen, Rachel K Redmann, Kelly Goff, Skye Spencer, Breanna Picou, Nadia Golden, Cecily C Midkiff, Duane J Bush, Luis M Branco, Matthew L Boisen, Hongmei Gao, David C Montefiori, Robert V Blair, Lara A Doyle-Meyers, Kasi Russell-Lodrigue, Nicholas J Maness, Chad J Roy
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010618 (2022)
The novel coronavirus SARS-CoV-2 emerged in late 2019, rapidly reached pandemic status, and has maintained global ubiquity through the emergence of variants of concern. Efforts to develop animal models have mostly fallen short of recapitulating sever
Externí odkaz:
https://doaj.org/article/520e4f07330948dfb9dec099171ac336