Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Chad G. Pearson"'
Autor:
Jamie L. Everman, Satria P. Sajuthi, Maude A. Liegeois, Nathan D. Jackson, Erik H. Collet, Michael C. Peters, Maurizio Chioccioli, Camille M. Moore, Bhavika B. Patel, Nathan Dyjack, Roger Powell, Cydney Rios, Michael T. Montgomery, Celeste Eng, Jennifer R. Elhawary, Angel C. Y. Mak, Donglei Hu, Scott Huntsman, Sandra Salazar, Luigi Feriani, Ana Fairbanks-Mahnke, Gianna L. Zinnen, Cole R. Michel, Joe Gomez, Xing Zhang, Vivian Medina, Hong Wei Chu, Pietro Cicuta, Erin D. Gordon, Pamela Zeitlin, Victor E. Ortega, Nichole Reisdorph, Eleanor M. Dunican, Monica Tang, Brett M. Elicker, Travis S. Henry, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, Elliot Israel, Bruce D. Levy, David T. Mauger, Deborah A. Meyers, Kaharu Sumino, David S. Gierada, Annette T. Hastie, Wendy C. Moore, Loren C. Denlinger, Nizar N. Jarjour, Mark L. Schiebler, Sally E. Wenzel, Prescott G. Woodruff, Jose Rodriguez-Santana, Chad G. Pearson, Esteban G. Burchard, John V. Fahy, Max A. Seibold
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical si
Externí odkaz:
https://doaj.org/article/e5fbd453726447a6a3e42371a05beeb5
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102915- (2021)
Summary: Dispersal is the movement of organisms from one habitat to another that potentially results in gene flow. It is often plastic, allowing organisms to adjust dispersal movements depending on environmental conditions. A fundamental aim in ecolo
Externí odkaz:
https://doaj.org/article/4dbc91b5b3b149618aa5de7be7598a6a
Publikováno v:
Biology Open, Vol 5, Iss 1, Pp 20-31 (2016)
Multi-ciliated cells (MCCs) use polarized fields of undulating cilia (ciliary array) to produce fluid flow that is essential for many biological processes. Cilia are positioned by microtubule scaffolds called basal bodies (BBs) that are arranged with
Externí odkaz:
https://doaj.org/article/cf4dd86bd93644ccbf79e6c866ddcd9e
Publikováno v:
Molecular Biology of the Cell. 34
An automated image analysis pipeline to map cell geometry and basal body organization in the ciliate Tetrahymena thermophila is described. Generative modeling was used to computationally reconstruct cell cycle progression from images of cells at sing
Autor:
Janelle C. Leggere, Jaime V.K. Hibbard, Ophelia Papoulas, Chanjae Lee, Chad G. Pearson, Edward M. Marcotte, John B. Wallingford
Publikováno v:
bioRxiv
DIFFRAC is a powerful method for systematically comparing proteome content and organization between samples in a high-throughput manner. By subjecting control and experimental protein extracts to native chromatography and quantifying the contents of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89aebe881cb807becc93910cf882f1f
https://doi.org/10.1101/2023.03.08.531778
https://doi.org/10.1101/2023.03.08.531778
Autor:
Cayla E Jewett, Bailey L McCurdy, Eileen T O'Toole, Alexander J Stemm-Wolf, Katherine S Given, Carrie H Lin, Valerie Olsen, Whitney Martin, Laura Reinholdt, Joaquín M Espinosa, Kelly D Sullivan, Wendy B Macklin, Rytis Prekeris, Chad G Pearson
Publikováno v:
eLife. 12
Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21. Yet how trisomy 21 and elevated Pericentrin disrupt cilia-related mole
Autor:
Cayla E Jewett, Bailey L McCurdy, Eileen T O'Toole, Alexander J Stemm-Wolf, Katherine S Given, Carrie H Lin, Valerie Olsen, Whitney Martin, Laura Reinholdt, Joaquín M Espinosa, Kelly D Sullivan, Wendy B Macklin, Rytis Prekeris, Chad G Pearson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eff97882767f035a39da8c4fcb1c6f24
https://doi.org/10.7554/elife.78202.sa2
https://doi.org/10.7554/elife.78202.sa2
Autor:
Anthony D. Junker, Louis G. Woodhams, Adam W. J. Soh, Eileen T. O’Toole, Philip V. Bayly, Chad G. Pearson
Publikováno v:
Molecular biology of the cell. 33(14)
Motile cilia beat with an asymmetric waveform consisting of a power stroke that generates a propulsive force and a recovery stroke that returns the cilium back to the start. Cilia are anchored to the cell cortex by basal bodies (BBs) that are directl
Autor:
Alexander J. Stemm-Wolf, Joaquín M. Espinosa, Chad G. Pearson, Cayla E. Jewett, Molishree Joshi, Rytis Prekeris, Huy Nguyen Duc, Bailey L. McCurdy
Publikováno v:
Molecular Biology of the Cell. 33
Trisomy 21, the cause of Down syndrome, causes a 0.5-fold protein increase of the chromosome 21-resident gene Pericentrin (PCNT) and reduces primary cilia formation and signaling. Here we investigate the mechanisms by which PCNT imbalances disrupt ci
Autor:
Chad G. Pearson, Cayla E. Jewett
Publikováno v:
Current Biology. 31:R337-R340
Extra centrosomes are linked to cancer-associated errors in cell division, metastasis and signaling. A new study reveals that centrosome amplification disrupts lysosome function, leading to the release of small extracellular vesicles and to invasive