Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Chad G Pearson"'
Autor:
Cayla E Jewett, Bailey L McCurdy, Eileen T O'Toole, Alexander J Stemm-Wolf, Katherine S Given, Carrie H Lin, Valerie Olsen, Whitney Martin, Laura Reinholdt, Joaquín M Espinosa, Kelly D Sullivan, Wendy B Macklin, Rytis Prekeris, Chad G Pearson
Publikováno v:
eLife, Vol 12 (2023)
Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21. Yet how trisomy 21 and elevated Pericentrin disrupt cilia-related mole
Externí odkaz:
https://doaj.org/article/603a4f2550174b548dd163691ee11a05
Autor:
Jasmina S Redzic, Agnieszka A Kendrick, Karim Bahmed, Kristin D Dahl, Chad G Pearson, William A Robinson, Steven E Robinson, Michael W Graner, Elan Z Eisenmesser
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71225 (2013)
Extracellular vesicles (EVs) are key contributors to cancer where they play an integral role in cell-cell communication and transfer pro-oncogenic molecules to recipient cells thereby conferring a cancerous phenotype. Here, we purified EVs using stra
Externí odkaz:
https://doaj.org/article/9b10f7f1fb554169969def960004fa66
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102915- (2021)
Summary: Dispersal is the movement of organisms from one habitat to another that potentially results in gene flow. It is often plastic, allowing organisms to adjust dispersal movements depending on environmental conditions. A fundamental aim in ecolo
Externí odkaz:
https://doaj.org/article/4dbc91b5b3b149618aa5de7be7598a6a
Publikováno v:
Molecular Biology of the Cell. 34
An automated image analysis pipeline to map cell geometry and basal body organization in the ciliate Tetrahymena thermophila is described. Generative modeling was used to computationally reconstruct cell cycle progression from images of cells at sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14a02af697aea4c96d791818496c55fc
https://doi.org/10.1091/mbc.e22-11-0508
https://doi.org/10.1091/mbc.e22-11-0508
Autor:
Janelle C. Leggere, Jaime V.K. Hibbard, Ophelia Papoulas, Chanjae Lee, Chad G. Pearson, Edward M. Marcotte, John B. Wallingford
Publikováno v:
bioRxiv
DIFFRAC is a powerful method for systematically comparing proteome content and organization between samples in a high-throughput manner. By subjecting control and experimental protein extracts to native chromatography and quantifying the contents of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89aebe881cb807becc93910cf882f1f
https://doi.org/10.1101/2023.03.08.531778
https://doi.org/10.1101/2023.03.08.531778
Publikováno v:
Biology Open, Vol 5, Iss 1, Pp 20-31 (2016)
Multi-ciliated cells (MCCs) use polarized fields of undulating cilia (ciliary array) to produce fluid flow that is essential for many biological processes. Cilia are positioned by microtubule scaffolds called basal bodies (BBs) that are arranged with
Externí odkaz:
https://doaj.org/article/cf4dd86bd93644ccbf79e6c866ddcd9e
Autor:
Cayla E Jewett, Bailey L McCurdy, Eileen T O'Toole, Alexander J Stemm-Wolf, Katherine S Given, Carrie H Lin, Valerie Olsen, Whitney Martin, Laura Reinholdt, Joaquín M Espinosa, Kelly D Sullivan, Wendy B Macklin, Rytis Prekeris, Chad G Pearson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eff97882767f035a39da8c4fcb1c6f24
https://doi.org/10.7554/elife.78202.sa2
https://doi.org/10.7554/elife.78202.sa2
Autor:
Anthony D. Junker, Louis G. Woodhams, Adam W. J. Soh, Eileen T. O’Toole, Philip V. Bayly, Chad G. Pearson
Publikováno v:
Molecular biology of the cell. 33(14)
Motile cilia beat with an asymmetric waveform consisting of a power stroke that generates a propulsive force and a recovery stroke that returns the cilium back to the start. Cilia are anchored to the cell cortex by basal bodies (BBs) that are directl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d2c041f334fe9aa57d3e0ed90fdaca
https://pubmed.ncbi.nlm.nih.gov/36287828
https://pubmed.ncbi.nlm.nih.gov/36287828
Autor:
Alexander J. Stemm-Wolf, Joaquín M. Espinosa, Chad G. Pearson, Cayla E. Jewett, Molishree Joshi, Rytis Prekeris, Huy Nguyen Duc, Bailey L. McCurdy
Publikováno v:
Molecular Biology of the Cell. 33
Trisomy 21, the cause of Down syndrome, causes a 0.5-fold protein increase of the chromosome 21-resident gene Pericentrin (PCNT) and reduces primary cilia formation and signaling. Here we investigate the mechanisms by which PCNT imbalances disrupt ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f94c2b5a2eda08559836083ef1f127
https://doi.org/10.1091/mbc.e21-10-0517-t
https://doi.org/10.1091/mbc.e21-10-0517-t
Autor:
Chad G. Pearson, Cayla E. Jewett
Publikováno v:
Current Biology. 31:R337-R340
Extra centrosomes are linked to cancer-associated errors in cell division, metastasis and signaling. A new study reveals that centrosome amplification disrupts lysosome function, leading to the release of small extracellular vesicles and to invasive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b654b772b58ae24e1663047ab7cde76
https://doi.org/10.1016/j.cub.2021.01.057
https://doi.org/10.1016/j.cub.2021.01.057