Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Chad E. Harris"'
Autor:
Alyssa L. Kennedy, Kasiani C. Myers, James Bowman, Christopher J. Gibson, Nicholas D. Camarda, Elissa Furutani, Gwen M. Muscato, Robert H. Klein, Kaitlyn Ballotti, Shanshan Liu, Chad E. Harris, Ashley Galvin, Maggie Malsch, David Dale, John M. Gansner, Taizo A. Nakano, Alison Bertuch, Adrianna Vlachos, Jeffrey M. Lipton, Paul Castillo, James Connelly, Jane Churpek, John R. Edwards, Nobuko Hijiya, Richard H. Ho, Inga Hofmann, James N. Huang, Siobán Keel, Adam Lamble, Bonnie W. Lau, Maxim Norkin, Elliot Stieglitz, Wendy Stock, Kelly Walkovich, Steffen Boettcher, Christian Brendel, Mark D. Fleming, Stella M. Davies, Edie A. Weller, Christopher Bahl, Scott L. Carter, Akiko Shimamura, R. Coleman Lindsley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Understanding the molecular basis of leukaemia predisposition is essential for intervention. The authors here investigate germline genetic leukaemia predisposition by studying Shwachman-Diamond syndrome and report compensatory inactivating mutations
Externí odkaz:
https://doaj.org/article/911d91b30d4548af8f9e72d025592f4b
Autor:
Safa F Mohamad, Meaghan McGuinness, Gabriele Casirati, Alejo E Rodriguez-Fraticelli, Chad E. Harris, Fernando D. Camargo, Pietro Genovese, Eric J Allenspach, David A. Williams
Publikováno v:
Blood. 140:8588-8589
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39a78694c770495554e6c5392c11319b
https://doi.org/10.1182/blood-2022-163606
https://doi.org/10.1182/blood-2022-163606
Autor:
Michael J. Peters, Anna Deck, April Hu, Yuko Fujiwara, Jinkuk Kim, Aubrie Soucy, Kevin Zhang, Julianna Kenny, Linda Y. Lin, Alyssa L. Kennedy, Caitlin Bowers, Chad E. Harris, Chi Yuan Zhang, Karthik Ponnienselvan, Pengpeng Liu, Kevin Luk, Davide Seruggia, R. Coleman Lindsley, John P. Manis, Christian Brendel, Scot A. Wolfe, Stuart H. Orkin, Timothy Yu, Akiko Shimamura, Daniel E. Bauer
Publikováno v:
Blood. 140:2944-2945
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4261a38b5255d4e71c859c635f58780c
https://doi.org/10.1182/blood-2022-169379
https://doi.org/10.1182/blood-2022-169379
Autor:
Olivier Negre, Swaroopa Guda, Christian Brendel, Chad E. Harris, Martin Bentler, Myriam Armant, Melissa Bonner, Erica B. Esrick, John P. Manis, Helene Trebeden-Negre, Axel Schambach, Alla V. Tsytsykova, Danilo Pellin, Michael Rothe, Lauryn Christiansen, Denise Klatt, David A. Williams, Meaghan McGuinness, Daniela Abriss, Geoff Parsons, Gabor Istvan Veres
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 589-600 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
In this work we provide preclinical data to support initiation of a first-in-human trial for sickle cell disease (SCD) using an approach that relies on reversal of the developmental fetal-to-adult hemoglobin switch. Erythroid-specific knockdown of BC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8fc0356964dd1fbe99f38977e8a66a
http://www.sciencedirect.com/science/article/pii/S2329050120300450
http://www.sciencedirect.com/science/article/pii/S2329050120300450
Autor:
Chad E. Harris
The purpose of this quantitative research study was to fill the gap in the current body of research regarding the leadership behavior characteristics, specifically servant leadership traits, exhibited by volunteer nonprofit board of director presiden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b781df5396c0260cdcff247423edc2c
https://doi.org/10.32469/10355/85776
https://doi.org/10.32469/10355/85776
Autor:
Chad E. Harris, Elizabeth Currin
Publikováno v:
Isn’t it Ironic?
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::699cdd2feb18b2f09d2c28c2055b3d82
https://doi.org/10.4324/9781003080350-8
https://doi.org/10.4324/9781003080350-8
Autor:
John M. Gansner, James Bowman, Jane E. Churpek, Gwen M. Muscato, Richard H. Ho, Adam J. Lamble, Mark D. Fleming, Robert H. Klein, Alison A. Bertuch, Shanshan Liu, Wendy Stock, Jeffrey M. Lipton, Christian Brendel, Ashley Galvin, James A. Connelly, Nicholas D. Camarda, Christopher J. Gibson, Christopher D. Bahl, Chad E. Harris, Kasiani C. Myers, Sioban Keel, R. Coleman Lindsley, Kelly Walkovich, Maggie Malsch, Bonnie W Lau, Alyssa L. Kennedy, Kaitlyn Ballotti, John R. Edwards, David C. Dale, Akiko Shimamura, Stella M. Davies, Elliot Stieglitz, Scott L. Carter, Paul Castillo, Steffen Boettcher, Taizo A. Nakano, Adrianna Vlachos, Maxim Norkin, Elissa Furutani, Edie Weller, Nobuko Hijiya, Inga Hofmann, James N. Huang
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
To understand the mechanisms that mediate germline genetic leukemia predisposition, we studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone marrow failure disorder with high risk of myeloid malignancies at an early age. To def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6bc53e8cfbeaac3fa14099826d19da
https://doi.org/10.1038/s41467-021-21588-4
https://doi.org/10.1038/s41467-021-21588-4
Autor:
Shuquan Rao, Yao Yao, Alyssa L. Kennedy, Kaitlyn Ballotti, Jing Zeng, Akiko Shimamura, Anne H. Shen, Ruth E. Watkinson, Chunyan Ren, Steven Coyne, Luca Pinello, Scot A. Wolfe, Peter E. Newburger, Roberto Chiarle, Qiuming Yao, Anna Victoria Serbin, Benhur Lee, Chad E. Harris, Christian S. Stevens, Myriam Armant, Josias Soares de Brito, Daniel E. Bauer, Sabine Studer, Kevin Luk
Publikováno v:
Cell Stem Cell
Severe congenital neutropenia (SCN) is a life-threatening disorder most often caused by dominant mutations of ELANE that interfere with neutrophil maturation. We conducted a pooled CRISPR screen in human hematopoietic stem and progenitor cells (HSPCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1a48c200730c47edad19a518d05e57
https://pubmed.ncbi.nlm.nih.gov/33961760
https://pubmed.ncbi.nlm.nih.gov/33961760
Autor:
Maxim Norkin, Sixi Liu, R. C. Lindsley, Alison A. Bertuch, Christopher D. Bahl, Ashley Galvin, Jane E. Churpek, Nicholas D. Camarda, Elissa Furutani, Wendy Stock, Jeffrey M. Lipton, Bonnie W Lau, Christian Brendel, James A. Connelly, Scott L. Carter, Steffen Boettcher, David C. Dale, Sioban Keel, Alyssa L. Kennedy, Kasiani C. Myers, Inga Hofmann, John R. Edwards, Akiko Shimamura, James Bowman, Chad E. Harris, James N. Huang, Richard H. Ho, Rüdiger Klein, Mark D. Fleming, Maggie Malsch, Taizo A. Nakano, Adrianna Vlachos, John M. Gansner, Christopher J. Gibson, Stella M. Davies, Elliot Stieglitz, Paul Castillo, Adam J. Lamble, Edie Weller, G. M. Muscato, Nobuko Hijiya, Kaitlyn Ballotti, Kelly Walkovich
Shwachman-Diamond syndrome (SDS) is an inherited bone marrow failure syndrome with predisposition to developing leukemia. We found that multiple independent somatic hematopoietic clones arise early in life, most commonly harboring heterozygous mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a72a878ae541d1387584ab459615d13
https://doi.org/10.1101/2020.06.04.134692
https://doi.org/10.1101/2020.06.04.134692
Autor:
Chad E. Harris, Francois Autelitano, Sheela Pangeni Pokharel, Meaghan McGuinness, Beatrice Duvert, Lu Yang, Chun-Wei David Chen, Monika Ermann, Andrew Anighoro, David R. Williams, Edward Beaumont, Sara Canovas Nunes, Pamela Klingbeil, Haiming Xu, Serena De Vita
Publikováno v:
Blood. 138:1199-1199
The activation of RAS signaling has been shown to act as the driver of both de novo and relapsed, chemotherapy resistant acute lymphoblastic leukemia (ALL). Full RAS transformation requires the activity of the small RAS-related C3 botulinum toxin sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bab480421c158b2741297ad1df9a62ca
https://doi.org/10.1182/blood-2021-147009
https://doi.org/10.1182/blood-2021-147009