Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Chad E. Hadden"'
Autor:
Charles A. Alt, Jeremy T. Spitler, Sathish K. Boini, Eric D. Moher, Chad E. Hadden, Scott Alan Frank, Radhe K. Vaid
Publikováno v:
Synthesis. 46:2463-2470
A high-yielding five-step synthesis of the title compound, methyl 7,9-dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate, starting from 2,4-dimethylaniline was developed. This synthesis involved N-alkylation of 2,4-dimethylaniline w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc99d123bce7a756e56d091e4564e0e9
https://doi.org/10.1055/s-0034-1378279
https://doi.org/10.1055/s-0034-1378279
Autor:
Jessica Rehmel, Ping Yi, Jason T. Johnson, Chad E. Hadden, Kristina M. Campanale, Nita J. Patel, Kenneth C. Cassidy
Publikováno v:
Drug Metabolism and Disposition. 40:2354-2364
The disposition and metabolism of isopropyl N-[(2S)-7-cyano-4-(2-pyridylmethyl)-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate (LY2452473; a selective androgen receptor modulator) in humans was characterized after a single 15-mg (100 μCi) oral dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b9626cc38227361d7e210964006d60
https://doi.org/10.1124/dmd.112.047613
https://doi.org/10.1124/dmd.112.047613
Autor:
Takanori Hashizume, Jeffrey J. Alberts, Kenneth E. Thummel, Nina Isoherranen, Michael A. Mohutsky, Thomas F. Kalhorn, Yang Xu, Chad E. Hadden, Margaret C. Shuhart
Publikováno v:
Biochemical Pharmacology. 75:1240-1250
The biological effects of 1α,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) are terminated primarily by P450-dependent hydroxylation reactions. However, the hormone is also conjugated in the liver and a metabolite, presumably a glucuronide, undergoes ent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91293aeb7d7d12adcb0d1ea0c794c1fa
https://doi.org/10.1016/j.bcp.2007.11.008
https://doi.org/10.1016/j.bcp.2007.11.008
Autor:
Eric D. Moher, Charles A. Alt, Chad E. Hadden, Radhe K. Vaid, Scott Alan Frank, Sathish K. Boini, Jeremy T. Spitler
Publikováno v:
ChemInform. 46
The synthesis of (Ia) on an industrial scale is elaborated and applied to the preparation of (Ib,c) and (II).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8179ead97d3a1c542e6a69e7a32c505b
https://doi.org/10.1002/chin.201509247
https://doi.org/10.1002/chin.201509247
Autor:
Jason T. Johnson, Ping Yi, Barry C. Peterson, David A. Jackson, Todd A. Gillespie, Chad E. Hadden, William F. Annes
Publikováno v:
Drug Metabolism and Disposition. 35:51-61
Naveglitazar [LY519818; benzenepropanoic acid, alpha-methoxy-4-[3-(4-phenoxyphenoxy)propoxy], (alpha-S)-] is a nonthiozolidinedione peroxisome proliferator-activated receptor alpha-gamma dual, gamma-dominant agonist that has shown glucose-lowering po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb194141f5422312d383039626f2956c
https://doi.org/10.1124/dmd.106.012328
https://doi.org/10.1124/dmd.106.012328
Autor:
Speaker Stanley M, Thomas J. Thamann, Tore Ramstad, Dirk L. Teagarden, Gary E. Martin, Chad E. Hadden
Publikováno v:
International Journal of Pharmaceutics. 296:55-63
A binding constant was determined for the complexation reaction between alprostadil (PGE1) and alpha-cyclodextrin (alpha-CD). This constant was used to calculate the fraction PGE1 free upon reconstitution of Caverject dual chamber syringe, indicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3d425568cd213e1b8b8907d512c9db
https://doi.org/10.1016/j.ijpharm.2005.02.018
https://doi.org/10.1016/j.ijpharm.2005.02.018
Autor:
Chad E. Hadden
Publikováno v:
Magnetic Resonance in Chemistry. 43:330-333
The application of adiabatic inversion pulses to the detection of 1H–15N heteronuclear correlations is described. The pulse sequences studied were gHSQC, CRISIS-gHSQC, gHMBC and CRISIS-gHMBC. The poor inversion quality of rectangular 180° X pulses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cfdb35e2516b7633faf79efb63ce5a
https://doi.org/10.1002/mrc.1543
https://doi.org/10.1002/mrc.1543
Publikováno v:
Journal of Heterocyclic Chemistry. 40:359-362
Synthetic efforts towards the indole alkaloid natural product roquefortine C resulted in the formation of an unknown intermediate. Elucidation of the structure of this molecule relied on the use of long-range 1H-15N 2D-NMR. Computational predictions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aefb2040ebf6c2a525b3cdefbe8e050
https://doi.org/10.1002/jhet.5570400227
https://doi.org/10.1002/jhet.5570400227
Autor:
Kenneth Rosenqvist, Chad E. Hadden, Mako N. Masuno, Gary E. Martin, Thomas J. Thamann, Brian D. Kaluzny, Wayne K. Duholke, Phillip E. Sanders, Byron C. Robinson
Publikováno v:
Journal of Heterocyclic Chemistry. 40:389-393
During the terminal heat sterilization of the lipid emulsion final dose formulation of the photodynamic therapeutic (PDT) agent tin ethyl etiopurpurin (SnET2), a new degradant was observed at very low levels. The degradant, which was prone to photo-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67f18e8282f148573bf48e9d94aba013
https://doi.org/10.1002/jhet.5570400233
https://doi.org/10.1002/jhet.5570400233
Autor:
Bruce A. Stiemsma, Antony J. Williams, Eduard R. Martirosian, Thomas J. Thamann, Sergey G. Molodtsov, Gary E. Martin, David J. Russell, Brian D. Kaluzny, Paul L. Schiff, Chad E. Hadden, Ronald C. Crouch, Kirill A. Blinov, Mikhail E. Elyashberg, Jane E. Guido, Wayne K. Duholke
Publikováno v:
Journal of Heterocyclic Chemistry. 39:1241-1250
Identification of degradants of pharmaceuticals is a necessary challenge of the drug development process following the subjection of candidate molecules to a variety of physico-chemical stresses. It would be desirable to be able to conduct such studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e3e43caa8b71528baa159a9d497e9d1
https://doi.org/10.1002/jhet.5570390619
https://doi.org/10.1002/jhet.5570390619