Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Chad E. Bigelow"'
Autor:
Timothy K. MacLachlan, Mark N. Milton, Oliver Turner, Francis Tukov, Vivian W. Choi, Jan Penraat, Marie-Hélène Delmotte, Lydia Michaut, Bruce D. Jaffee, Chad E. Bigelow
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 8, Iss C, Pp 105-120 (2018)
Retinitis pigmentosa is a form of retinal degeneration usually caused by genetic mutations affecting key functional proteins. We have previously demonstrated efficacy in a mouse model of RLBP1 deficiency with a self-complementary AAV8 vector carrying
Externí odkaz:
https://doaj.org/article/7326adf338ee446f8ac97a123971d3ee
Autor:
Joy G. Ghosh, Andrew A. Nguyen, Chad E. Bigelow, Stephen Poor, Yubin Qiu, Nalini Rangaswamy, Richard Ornberg, Brittany Jackson, Howard Mak, Tucker Ezell, Vania Kenanova, Elisa de la Cruz, Ana Carrion, Bijan Etemad-Gilbertson, Roxana Garcia Caro, Kan Zhu, Vinney George, Jirong Bai, Radhika Sharma-Nahar, Siyuan Shen, Yiqin Wang, Kulandayan K. Subramanian, Elizabeth Fassbender, Michael Maker, Shawn Hanks, Joanna Vrouvlianis, Barrett Leehy, Debby Long, Melissa Prentiss, Viral Kansara, Bruce Jaffee, Thaddeus P. Dryja, Michael Roguska
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Retinal vascular disease treatments involve frequent pharmacological intraocular administrations. Here the authors present a method to increase the half-life of injected drugs by fusing these to a hyaluronan-binding peptide, which might lead to less
Externí odkaz:
https://doaj.org/article/f0adf43d440f4267b734d5d4506d7186
Autor:
Maura A Crowley, Donita L Garland, Holger Sellner, Angela Banks, Lin Fan, Tomas Rejtar, Natasha Buchanan, Omar Delgado, Yong Yao Xu, Sandra Jose, Christopher M Adams, Muneto Mogi, Karen Wang, Chad E Bigelow, Stephen Poor, Karen Anderson, Bruce D Jaffee, Ganesh Prasanna, Cynthia Grosskreutz, Rosario Fernandez-Godino, Eric A Pierce, Thaddeus P Dryja, Sha-Mei Liao
Publikováno v:
Human Molecular Genetics. 32:204-217
EFEMP1 R345W is a dominant mutation causing Doyne honeycomb retinal dystrophy/malattia leventinese (DHRD/ML), a rare blinding disease with clinical pathology similar to age-related macular degeneration (AMD). Aged Efemp1 R345W/R345W knock-in mice (Ef
Autor:
Joanna Vrouvlianis, Xiaoqiu Wu, Christie L. Bell, Viral Kansara, Q Medley, Henry Y. Wu, Qian Huang, Hui Li, Terri L. McGee, Barrett Leehy, Vanessa Kainz, Melissa Prentiss, YongYao Xu, A.P. da Cunha, Qin Zhang, Chad E Bigelow, Nalini Rangaswamy
Publikováno v:
Current Eye Research. 43:553-565
The concept of tissue-dependent cytokine hierarchy has been demonstrated in a number of diseases, but it has not been investigated in ophthalmic diseases. Here, we evaluated the functional hierarchy of interleukin-1β (IL-1β), IL-6, IL-17A, and tumo
Autor:
Ana Carrion, Debby Long, Andrew Anh Nguyen, Michael Roguska, Elisa de la Cruz, Bruce D Jaffee, Stephen Poor, Kulandayan K. Subramanian, Bijan Etemad-Gilbertson, Vania Kenanova, Shawn Hanks, Roxana Garcia Caro, Nalini Rangaswamy, Kan Zhu, Barrett Leehy, Elizabeth Fassbender, Chad E Bigelow, Howard H. Mak, Joy Ghosh, Jirong Bai, Yubin Qiu, Viral Kansara, Radhika Sharma-Nahar, Siyuan Shen, Michael Maker, Melissa Prentiss, Brittany Jackson, Richard Ornberg, Joanna Vrouvlianis, Vinney George, Yiqin Wang, Tucker Ezell, Thaddeus P. Dryja
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
Protein drugs that neutralize vascular endothelial growth factor (VEGF), such as aflibercept or ranibizumab, rescue vision in patients with retinal vascular diseases. Nonetheless, optimal visual outcomes require intraocular injections as frequently a
Autor:
Christopher M. Adams, Ganesh Prasanna, Cynthia L. Grosskreutz, Rebecca C. Stacy, Nalini Rangaswamy, Chad E Bigelow
Publikováno v:
Pharmaceutical Research. 36
The future of next generation therapeutics for glaucoma is strong. The recent approval of two novel intraocular pressure (IOP)-lowering drugs with distinct mechanisms of action is the first in over 20 years. However, these are still being administere
Autor:
Barrett Leehy, Vanessa Davis, Valentin M. Sluch, Chad E Bigelow, Dennis S Rice, Angela Banks, Joanna Vrouvlianis, Jorge Aranda, Alexandra M. Hyman, Chuanxi Xiang, John Demirs, Junzheng Yang, Hui Li, Maura Crowley, Bo Chang, Shawn Hanks
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
The knockout (KO) of the adiponectin receptor 1 (AdipoR1) gene causes retinal degeneration. Here we report that ADIPOR1 protein is primarily found in the eye and brain with little expression in other tissues. Further analysis of AdipoR1 KO mice revea
Autor:
Valentin M, Sluch, Angela, Banks, Hui, Li, Maura A, Crowley, Vanessa, Davis, Chuanxi, Xiang, Junzheng, Yang, John T, Demirs, Joanna, Vrouvlianis, Barrett, Leehy, Shawn, Hanks, Alexandra M, Hyman, Jorge, Aranda, Bo, Chang, Chad E, Bigelow, Dennis S, Rice
Publikováno v:
Scientific reports. 8(1)
The knockout (KO) of the adiponectin receptor 1 (AdipoR1) gene causes retinal degeneration. Here we report that ADIPOR1 protein is primarily found in the eye and brain with little expression in other tissues. Further analysis of AdipoR1 KO mice revea
Autor:
Timothy K, MacLachlan, Mark N, Milton, Oliver, Turner, Francis, Tukov, Vivian W, Choi, Jan, Penraat, Marie-Hélène, Delmotte, Lydia, Michaut, Bruce D, Jaffee, Chad E, Bigelow
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Retinitis pigmentosa is a form of retinal degeneration usually caused by genetic mutations affecting key functional proteins. We have previously demonstrated efficacy in a mouse model of RLBP1 deficiency with a self-complementary AAV8 vector carrying
Autor:
Vivian W Choi, Chad E Bigelow, Terri L McGee, Akshata N Gujar, Hui Li, Shawn M Hanks, Joanna Vrouvlianis, Michael Maker, Barrett Leehy, Yiqin Zhang, Jorge Aranda, George Bounoutas, John T Demirs, Junzheng Yang, Richard Ornberg, Yu Wang, Wendy Martin, Kelly R Stout, Gregory Argentieri, Paul Grosenstein, Danielle Diaz, Oliver Turner, Bruce D Jaffee, Seshidhar R Police, Thaddeus P Dryja
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss, Pp-(2015)
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss, Pp-(2015)
Recessive mutations in RLBP1 cause a form of retinitis pigmentosa in which the retina, before its degeneration leads to blindness, abnormally slowly recovers sensitivity after exposure to light. To develop a potential gene therapy for this condition,