Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Chad Dalton"'
Publikováno v:
Pharmaceutical Research. 39:3197-3208
Precipitation of amorphous solid dispersions has gained traction in the pharmaceutical industry given its application to pharmaceuticals with varying physicochemical properties. Although preparing co-precipitated amorphous dispersions (cPAD) in high-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f118e861145f78def82eeea01880475
https://doi.org/10.1007/s11095-022-03416-6
https://doi.org/10.1007/s11095-022-03416-6
Autor:
Derek S. Frank, Haichen Nie, Anagha Chandra, Alexander Coelho, Chad Dalton, Hannah Dvorak, Ahmed Elkhabaz, Mairead Fahy, James Ormes, Andrew Parker, Ashish Punia, Jasmine Rowe, Luke Schenck, Daniel Smith, Neil A. Strotman, Michael Wang, Laura Wareham
Publikováno v:
Journal of Pharmaceutical Sciences.
Amorphous solid dispersions (ASDs) are an attractive option to improve the bioavailability of poorly water-soluble compounds. However, the material attributes of ASDs can present formulation and processability challenges, which are often mitigated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c68bc3e036cdd6b8b193a9258295ba2
https://doi.org/10.1016/j.xphs.2022.09.007
https://doi.org/10.1016/j.xphs.2022.09.007
Autor:
Robert F. Meyer, Daniel Skomski, Heidi Ferguson, Manoharan Ramasamy, Pierre Daublain, Allen C. Templeton, Yash Kapoor, Chad Dalton, Gregory M. Troup
Publikováno v:
Molecular pharmaceutics. 18(7)
The process of bringing a drug to market involves innumerable decisions to refine a concept into a final product. The final product goes through extensive research and development to meet the target product profile and to obtain a product that is man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfb66faab3b75f9510b9dc84e060075
https://pubmed.ncbi.nlm.nih.gov/34165309
https://pubmed.ncbi.nlm.nih.gov/34165309
Publikováno v:
Drug development and industrial pharmacy. 44(9)
Lipid-based drug delivery systems have been intensively investigated as a means of delivering poorly water-soluble drugs. Upon ingestion, the lipases in the gastrointestinal tract digest lipid ingredients, mainly triglycerides, within the formulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1497c64bc32cdd6b5a9eec21a946c3
https://pubmed.ncbi.nlm.nih.gov/29873584
https://pubmed.ncbi.nlm.nih.gov/29873584
Autor:
Luke Schenck, Xiaoling Jin, Chad Dalton, Melanie Marota, Athanas Koynov, Alfred C. F. Rumondor, Amanda K. P. Mann
Publikováno v:
Journal of pharmaceutical sciences. 107(1)
Many small-molecule active pharmaceutical ingredients (APIs) exhibit low aqueous solubility and benefit from generation of amorphous dispersions of the API and polymer to improve their dissolution properties. Spray drying and hot-melt extrusion are 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d2f79e227a360881b63fa663ad333c
https://pubmed.ncbi.nlm.nih.gov/28711592
https://pubmed.ncbi.nlm.nih.gov/28711592
Autor:
Danielle Denis, François G. Gervais, Rino Stocco, Stephen Lau, Birgit Kosjek, Michel Gallant, Vouy Linh Truong, Helmi Zaghdane, Dan Sørensen, Deborah Slipetz, Christophe Mellon, Gary P. O'Neill, Ernest E. Lee, Robert Houle, Yves Leblanc, Carl Berthelette, Daniel Guay, Carmela Molinaro, Jean-François Lévesque, Elizabeth Wong, Jin Wu, Yves Ducharme, Michael A. Crackower, John Colucci, Connie M. Krawczyk, Richard Friesen, Paul D. O’Shea, Nicole Sawyer, Susan Sillaots, Zhaoyin Wang, Christian Beaulieu, Daniel Simard, Chad Dalton, Wayne Mullet, Martine Hamel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:288-293
In this manuscript we wish to report the discovery of MK-7246 (4), a potent and selective CRTH2 (DP2) antagonist. SAR studies leading to MK-7246 along with two synthetic sequences enabling the preparation of this novel class of CRTH2 antagonist are r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62517a8c6d9944543c6229358efce07b
https://doi.org/10.1016/j.bmcl.2010.11.015
https://doi.org/10.1016/j.bmcl.2010.11.015
Autor:
Ivan Santos, Roy Helmy, Elizabeth Kwong, Robert Wenslow, and Chad Dalton, Narayan Variankaval, Robert Hartman, Sophie-Dorothee Clas, Jerry A. Murry
Publikováno v:
Crystal Growth & Design. 6:690-700
Evidence for a series of nonstoichiometric, isostructural, cocrystalline complexes of L-883555, a phosphodiesterase-IV inhibitor, and l-tartaric acid with stoichiometries ranging from 0.3:1 to 0.9:1 is reported here. The free base form of this compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7a3b02bb1f41686777f8bb26cf98850
https://doi.org/10.1021/cg050462u
https://doi.org/10.1021/cg050462u
Publikováno v:
Pharmaceutical Science & Technology Today. 2:311-320
Differential scanning calorimetry (DSC) is frequently the pharmaceutical thermal analysis technique of choice because of its ability to provide detailed information about both the physical and energetic properties of a substance. This review provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1fe3d9040dcb917cd577d707d50ed8
https://doi.org/10.1016/s1461-5347(99)00181-9
https://doi.org/10.1016/s1461-5347(99)00181-9
Publikováno v:
Pharmaceutical Research. 15:762-767
Purpose. To evaluate a simple calorimetric method for estimating the fragility of amorphous pharmaceutical materials from the width of the glass transition region. Methods. The glass transition temperature regions of eleven amorphous pharmaceutical m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55d286f2e58320e10d52b6ed0f10b365
https://doi.org/10.1023/a:1011931305755
https://doi.org/10.1023/a:1011931305755
Autor:
Chad Dalton, Bruno C. Hancock
Publikováno v:
International Journal of Pharmaceutics. 156:143-151
Several excipients and their formulations were equilibrated at relative humidities and temperatures selected to simulate typical pharmaceutical storage and processing conditions. Three different water detection techniques—loss on drying, Karl Fisch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17b81fbb8f735dee088cf46ee980660a
https://doi.org/10.1016/s0378-5173(97)04983-1
https://doi.org/10.1016/s0378-5173(97)04983-1