Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chad D. Moore"'
Autor:
Jessica K Roberts, Chad D Moore, Erin G Romero, Robert M Ward, Garold S Yost, Christopher A Reilly
Publikováno v:
F1000Research, Vol 2 (2013)
Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma. However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by C
Externí odkaz:
https://doaj.org/article/bff3aa7de4a14938946730ef4ff1a6d5
Autor:
Trevor P. Fidler, Christopher A. Reilly, Garold S. Yost, Christopher R. Orton, Jessica K. Roberts, Chad D. Moore, Takahiro Murai, Robert M. Ward
Publikováno v:
Drug Metabolism and Disposition. 41:379-389
Asthma is one of the most prevalent diseases in the world, for which the mainstay treatment has been inhaled glucocorticoids (GCs). Despite the widespread use of these drugs, approximately 30% of asthma sufferers exhibit some degree of steroid insens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2a8303023088c32ceddaa7ad226ce4
https://doi.org/10.1124/dmd.112.046318
https://doi.org/10.1124/dmd.112.046318
Autor:
Elizabeth M. J. Gillam, Dae-Hwan Kim, James B. Y. H. Behrendorff, Wayne A. Johnston, Christopher A. Smith, Chul-Ho Yun, Keon Hee Kim, Garold S. Yost, Chad D. Moore
Publikováno v:
Chemical Research in Toxicology. 25:1964-1974
Cytochrome P450 2F1 (P450 2F1) is expressed exclusively in the human respiratory tract and is implicated in 3-methylindole (3MI)-induced pneumotoxicity via dehydrogenation of 3MI to a reactive electrophilic intermediate, 3-methyleneindolenine (3-MEI)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eda80f189f7b843219aa97584b6d59d
https://doi.org/10.1021/tx300281g
https://doi.org/10.1021/tx300281g
Publikováno v:
Drug Metabolism and Disposition. 40:642-647
The aim of this study was to determine whether mouse CYP2A5 and CYP2F2 play critical roles in the bioactivation of 3-methylindole (3MI), a tissue-selective toxicant, in the target tissues, the nasal olfactory mucosa (OM) and lung. Five metabolites of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b784b10d0a34625603b1e2b10db70b6
https://doi.org/10.1124/dmd.111.044081
https://doi.org/10.1124/dmd.111.044081
Publikováno v:
Biochemistry. 49:9011-9019
The use of molecular modeling in conjunction with site-directed mutagenesis has been extensively used to study substrate orientation within cytochrome P450 active sites and to identify potential residues involved in the positioning and catalytic mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a288ca54566dc6ed54ed06069d861311
https://doi.org/10.1021/bi101139q
https://doi.org/10.1021/bi101139q
Publikováno v:
Biochemistry. 49:4466-4475
Raloxifene was approved in 2007 by the FDA for the chemoprevention of breast cancer in postmenopausal women at high risk for invasive breast cancer. Approval was based in part on the improved safety profile for raloxifene relative to the standard tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a204c00e2475e9c9ecdaeb7ca00cd17
https://doi.org/10.1021/bi902213r
https://doi.org/10.1021/bi902213r
Publikováno v:
Drug Metabolism and Disposition. 37:672-684
4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide), an indoline-containing diuretic drug, has recently been evaluated in a large Phase III clinical trial (ADVANCE) with a fixed-dose combination of an angiotensin-converting enzyme inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d551570b917ba0c59c756092ee9417
https://doi.org/10.1124/dmd.108.022707
https://doi.org/10.1124/dmd.108.022707
Publikováno v:
A Case Approach to Perioperative Drug-Drug Interactions ISBN: 9781461474944
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29701c1a4011c2c6fcec8f001f95c96f
https://doi.org/10.1007/978-1-4614-7495-1_18
https://doi.org/10.1007/978-1-4614-7495-1_18
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 345(2)
Inhaled glucocorticoids, such as beclomethasone dipropionate (BDP), are the mainstay treatment of asthma. However, ≈ 30% of patients exhibit little to no benefit from treatment. It has been postulated that glucocorticoid resistance, or insensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf5dca57c9efff44de1f691f260cdc5
https://pubmed.ncbi.nlm.nih.gov/23512537
https://pubmed.ncbi.nlm.nih.gov/23512537
Autor:
William K. Nichols, Jessica M. Weems, Garold S. Yost, John G. Lamb, David Martin, Chad D. Moore, Evan Makin, Ned. S. Cutler
Previous work has shown that bioactivation of the cigarette smoke pneumotoxicant 3-methylindole (3MI) by pulmonary cytochrome P450 enzymes is directly associated with formation of DNA adducts. Here, we present evidence that normal human lung epitheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3431714a3ea97839b531465b1849a8
https://europepmc.org/articles/PMC2769061/
https://europepmc.org/articles/PMC2769061/