Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Chad C. Stessman"'
Autor:
Christopher W. Dicus, Zackary D. Crane, Robert B. Bates, Chad C. Stessman, Michelle R. Gramme, George R. Pettit, Ernest Hamel, David S. Martinez, Kelly J. McClure, Bilal A. Sufi, Jacob Marcischak, Gayle V. Yarick, Pichaya Nakkiew, Md. Ahad Ali
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:4138-4152
Twenty analogues of the natural antitumor agent dolastatin 11, including majusculamide C, were synthesized and tested for cytotoxicity against human cancer cells and stimulation of actin polymerization. Only analogues containing the 30-membered ring
Publikováno v:
Journal of Natural Products. 66:939-942
A Fijian collection of the calcareous sponge Leucetta sp. was investigated and yielded four new imidazole alkaloids. One compound, (+)-calcaridine A (6), is unique in its overall structure and consists of a geminally substituted 2-aminoimidazolidinon
Autor:
Larry Oien, Chad C. Stessman, Sung-Gyu Kim, James W. Christensen, MariJean Eggen, Mukund P. Sibi
Publikováno v:
Tetrahedron Letters. 36:6209-6212
The use of N-methoxy-N-methylamide as a chemoselective group in Dieckmann-like condensation is described. The chemoselectivity in these cyclizations is dependent on the counterion of the base employed.
Autor:
Jianliang Lu, Chad C. Stessman, Jeffrey A. Schultz, Mukund P. Sibi, Mali Marvin, James W. Christensen
Publikováno v:
ChemInform. 26
Carboxylic acids can be converted to their corresponding N-methoxy-N-methylamides in high yields using 2-chloro-1-methylpyridinium iodide as the coupling agent. The reaction proceeds without racemization when chiral carboxylic acids are used as the s
Autor:
MariJean Eggen, Chad C. Stessman, James W. Christensen, Mukund P. Sibi, Larry Oien, Sung-Gyu Kim
Publikováno v:
ChemInform. 26
The use of N-methoxy-N-methylamide as a chemoselective group in Dieckmann-like condensation is described. The chemoselectivity in these cyclizations is dependent on the counterion of the base employed.
Publikováno v:
Magnetic Resonance in Chemistry. 36:539-541
Autor:
Wei Cui, Heiko Schadow, Gregory P. Rouen, Roger J. Bontems, Robert B. Bates, Kelly J. McClure, Jennifer J. Burns, Stuart R. Taylor, George R. Pettit, Sriyani Caldera, Gayle V. Yarick, Chad C. Stessman, Vicky H. Vu, Kennard G. Brusoe, Jianxing Zhang, Sanjeev Gangwar, Michelle R. Gramme
Publikováno v:
Journal of the American Chemical Society. 119:2111-2113
The first synthesis of dolastatin 11, a potent antineoplastic agent from the sea hare Dolabella auricularia, confirmed the proposed structure and established the last configuration in this natural ...
Autor:
Theodore R. Holman, Chad C. Stessman, Jon Clardy, Phillip Crews, Christopher P. Loo, Tyler A. Johnson, Emil B. Lobkovsky, Stephanie Whitman, Taro Amagata
Publikováno v:
Journal of natural products. 66(2)
To sharpen the search for new lipoxygenase inhibitors, we designed a screen to probe for both potency and selectivity. The assay utilized 12-human (12-HLO), 15-human (15-HLO), and 15-soybean (15-SLO) lipoxygenases. The IC(50) value data obtained prov
Publikováno v:
Journal of natural products. 65(8)
The sesterterpene constituents of two Indo-Pacific sponges were investigated and rapidly characterized using aggressive dereplication methods along with gradient 1D NMR techniques. Lendenfeldia frondosa yielded three sesterterpenes: 12beta,16beta,22-
Autor:
Chad C. Stessman, Vishwakarma Singh, Michael D. Carducci, S. Prathap, Sanjoy Lahiri, Vinayak V. Kane, Robert B. Bates
Publikováno v:
IndraStra Global.
On treatment with sodium hydride, a mixture of ketone 1 and enone 4 gives a 48% yield of adduct 2, which contains two new carbon-carbon bonds. The reaction very likely involves homodienolate 3, which may either undergo a Michael addition or a cycload