Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Chad C Black"'
Autor:
Jeffrey B Kaplan, Kevin D Mlynek, Hashani Hettiarachchi, Yonas A Alamneh, Lionel Biggemann, Daniel V Zurawski, Chad C Black, Charles E Bane, Robert K Kim, Mark S Granick
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205526 (2018)
Staphylococcal extracellular polymeric substances (EPS) such as extracellular DNA (eDNA) and poly-N-acetylglucosamine surface polysaccharide (PNAG) mediate numerous virulence traits including host colonization and antimicrobial resistance. Previous s
Externí odkaz:
https://doaj.org/article/0a6e3a1ad6de45fe852d4bcbf8971cd5
Autor:
Roland A. Cooper, Susan E. Leed, Qiang Zeng, Kevin A. Reynolds, Lacy Gaynor-Ohnstad, Lisa Xie, Hsiuling Lin, Jason C. Sousa, Jianbing Mu, Heather Gaona, Raul Olmeda, Martin J. Smilkstein, Brett R. Bayles, Brittney Potter, Michael K. Riscoe, Richard J. Sciotti, Papireddy Kancharla, Yuexin Li, Brian Vesely, Sovitj Pou, Sean R. Marcsisin, Chau Vuong, Qigui Li, Brandon S. Pybus, Lisa Read, Victor Melendez, Norma Roncal, Thu Lan Luong, Diana Caridha, Chad C. Black, Rozalia A. Dodean, Jing Zhang, Kirk Butler, Patrick K Tumwebaze, Charles E. Bane, Philip J. Rosenthal, Stephanie A Rasmussen, Mara Kreishman-Deitrick, Jane Xu Kelly, Frida G. Ceja, Ping Zhang, Christina K. Nolan
Publikováno v:
J Med Chem
The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for p
Autor:
Brittany I Garry, Joseph B. Long, Brittney Potter, Jason C. Sousa, Jonathan P. Shearer, Venkatasivasaisujith Sajja, Vlado Antonic, Ken Nguyen, Chad C. Black, Maria Medina-Rojas, Yonas Alamneh, Samandra T. Demons, Chau Vuong, Daniel V. Zurawski, Donna M. Wilder, Stuart D. Tyner
Publikováno v:
Military Medicine. 185:256-262
Objective Infection as sequelae to explosion-related injury is an enduring threat to our troops. There are limited data on the effects of blast on antibiotic pharmacokinetics (PK), pharmacodynamics (PD), and efficacy. The observational study presente
Autor:
Gert-Jan Wijnant, Charles E. Mowbray, Diana Caridha, Katrien Van Bocxlaer, Simon L. Croft, Richard J. Sciotti, Brian Vesely, Vanessa Yardley, Jean-Robert Ioset, Chad C. Black, Susan E. Leed, Stéphanie Braillard
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 11, Iss, Pp 129-138 (2019)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
Objectives Drugs for Neglected Diseases initiative (DNDi) has identified three chemical lead series, the nitroimidazoles, benzoxaboroles and aminopyrazoles, as innovative treatments for visceral leishmaniasis. The leads discovered using phenotypic sc
Autor:
Alex G. Waterson, Gary A. Sulikowski, Edward J. Metzger, Alec Walter, Richard J. Sciotti, Sydney L. Drury, Scott B Joseph, Chad C. Black, E. Duco Jansen, Eric P. Skaar, Mary T. Macdonald, Mingfeng Bai, Brendan F. Dutter, Clare L. Laut, Meng Su, James E. Crowe, Charles E. Bane, Anderson R. Miller, Monique R. Bennett, Ian M. Romaine, Bingwen Jing
Publikováno v:
Antimicrob Agents Chemother
Staphylococcus aureus is a serious threat to public health due to the rise of antibiotic resistance in this organism, which can prolong or exacerbate skin and soft tissue infections (SSTIs). Methicillin-resistant S. aureus is a Gram-positive bacteriu
Autor:
Jing Zhang, Brittney Potter, Chad C. Black, Samantha O. Aylor, Lisa Xie, Chau Vuong, Jason C. Sousa, Qigui Li, Qiang Zeng
Publikováno v:
Military Medicine. 184:106-113
Particle size is an important determinant of gastrointestinal absorption of compounds administrated orally. The present study evaluates the effect of a reduction in particle size assessed by homogenization, sonication, and homogenization plus sonicat
Autor:
Anna C. Jacobs, Mitchell G. Thompson, Chad C. Black, Jennifer L. Kessler, Lily P. Clark, Christin N. McQueary, Hanan Y. Gancz, Brendan W. Corey, Jay K. Moon, Yuanzheng Si, Matthew T. Owen, Justin D. Hallock, Yoon I. Kwak, Amy Summers, Charles Z. Li, David A. Rasko, William F. Penwell, Cary L. Honnold, Matthew C. Wise, Paige E. Waterman, Emil P. Lesho, Rena L. Stewart, Luis A. Actis, Thomas J. Palys, David W. Craft, Daniel V. Zurawski
Publikováno v:
mBio, Vol 5, Iss 3 (2014)
ABSTRACT Acinetobacter baumannii is recognized as an emerging bacterial pathogen because of traits such as prolonged survival in a desiccated state, effective nosocomial transmission, and an inherent ability to acquire antibiotic resistance genes. A
Externí odkaz:
https://doaj.org/article/1b43211c013b47cab03bc8955db93438
Autor:
Anchalee Tungtaeng, John H. Adams, Christina K. Nolan, Pattaraporn Vanachayangkul, Piyaporn Saingam, Philip L. Smith, Matthew D Wegner, Gregory A. Reichard, Richard J. Sciotti, Brian Vesely, Rawiwan Imerbsin, Kevin C. Kobylinski, Chanikarn Kodchakorn, Chad C. Black, Alison Roth, Chaiyaporn Chaisatit, Luis A Lugo, Brandon S. Pybus, Mariusz Wojnarski
Previously, ivermectin (1–10 mg/kg) was shown to inhibit liver-stage development of Plasmodium berghei in orally dosed mice. Here, ivermectin showed inhibition of the in vitro development of Plasmodium cynomolgi schizonts (IC50 = 10.42 μM) and hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8682b0a3b1f0cf282ebc46b6c374733c
https://doi.org/10.1101/2020.04.27.065409
https://doi.org/10.1101/2020.04.27.065409
Autor:
Mariusz Wojnarski, Chanikarn Kodchakorn, Alison Roth, Luis A Lugo-Roman, Chaiyaporn Chaisatit, Pattaraporn Vanachayangkul, Philip L. Smith, Christina K. Nolan, John H. Adams, Chad C. Black, Kevin C. Kobylinski, Anchalee Tungtaeng, Rawiwan Imerbsin, Richard J. Sciotti, Brian Vesely, Piyaporn Saingam, Gregory A. Reichard, Brandon S. Pybus, Matthew D Wegner
Publikováno v:
Antimicrobial Agents and Chemotherapy
Previously, ivermectin (1 to 10 mg/kg of body weight) was shown to inhibit the liver-stage development of Plasmodium berghei in orally dosed mice. Here, ivermectin showed inhibition of the in vitro development of Plasmodium cynomolgi schizonts (50% i
Autor:
Yuexin Li, Kirk Butler, Brittney Potter, Qigui Li, Papireddy Kancharla, Roland A. Cooper, Thu Lan Luong, Heather Gaona, Jing Zhang, Richard J. Sciotti, Brian Vesely, Chau Vuong, Qiang Zeng, Sean R. Marcsisin, Michael K. Riscoe, Diana Caridha, Jason C. Sousa, Rolf W. Winter, Norma Roncal, Christina K. Nolan, Lisa Read, Rozalia A. Dodean, Lisa Xie, Lacy Gaynor-Ohnstad, Stephanie J. Huezo, Susan E. Leed, Hsiuling Lin, John C. Tan, Martin J. Smilkstein, Stephanie A Rasmussen, Jane Xu Kelly, Ping Zhang, Chad C. Black, Melissa T. Stephens, Mara Kreishman-Deitrick, Raul Olmeda, Victor Melendez, Sovitj Pou, Charles E. Bane
Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support the renewed eradication agenda. We have discovered a novel antimalarial acridone chemotype with dual-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351c0f6f16032d54883ac7a5e8be555b
https://europepmc.org/articles/PMC6822569/
https://europepmc.org/articles/PMC6822569/