Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Chad A Brautigam"'
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0283952 (2023)
The mechanisms of energy generation and carbon-source utilization in the syphilis spirochete Treponema pallidum have remained enigmatic despite complete genomic sequence information. Whereas the bacterium harbors enzymes for glycolysis, the apparatus
Externí odkaz:
https://doaj.org/article/196bc4dc0aca49bfb91694a6df70890b
Publikováno v:
eLife, Vol 8 (2019)
RET is a receptor tyrosine kinase (RTK) that plays essential roles in development and has been implicated in several human diseases. Different from most of RTKs, RET requires not only its cognate ligands but also co-receptors for activation, the mech
Externí odkaz:
https://doaj.org/article/9170d56b942a49c3bc5ccdc2d8982bc2
Autor:
Abhilash Padavannil, Prithwijit Sarkar, Seung Joong Kim, Tolga Cagatay, Jenny Jiou, Chad A Brautigam, Diana R Tomchick, Andrej Sali, Sheena D'Arcy, Yuh Min Chook
Publikováno v:
eLife, Vol 8 (2019)
We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface. The nature of this interface coupled with qua
Externí odkaz:
https://doaj.org/article/ae5e9b8718834362977feb5ecb5f7a66
Publikováno v:
eLife, Vol 7 (2018)
Stu2/XMAP215 microtubule polymerases use multiple tubulin-binding TOG domains and a lattice-binding basic region to processively promote faster elongation. How the domain composition and organization of these proteins dictate polymerase activity, end
Externí odkaz:
https://doaj.org/article/8e0e666aeea8494aa1a4e50021c19aa5
Publikováno v:
eLife, Vol 6 (2017)
The Hippo pathway controls tissue growth and homeostasis through a central MST-LATS kinase cascade. The scaffold protein SAV1 promotes the activation of this kinase cascade, but the molecular mechanisms remain unknown. Here, we discover SAV1-mediated
Externí odkaz:
https://doaj.org/article/46e9813d5842481486974ae51de0aa6e
Publikováno v:
eLife, Vol 6 (2017)
Neurotransmitter release depends on the SNARE complex formed by syntaxin-1, synaptobrevin and SNAP-25, as well as on complexins, which bind to the SNARE complex and play active and inhibitory roles. A crystal structure of a Complexin-I fragment beari
Externí odkaz:
https://doaj.org/article/1127a557f0c14f518c2d09fe4d8f442a
Autor:
Baoyu Chen, Hui-Ting Chou, Chad A Brautigam, Wenmin Xing, Sheng Yang, Lisa Henry, Lynda K Doolittle, Thomas Walz, Michael K Rosen
Publikováno v:
eLife, Vol 6 (2017)
The Rho GTPase Rac1 activates the WAVE regulatory complex (WRC) to drive Arp2/3 complex-mediated actin polymerization, which underpins diverse cellular processes. Here we report the structure of a WRC-Rac1 complex determined by cryo-electron microsco
Externí odkaz:
https://doaj.org/article/d8f2a102fa8b48d786f9e435625e56f9
Autor:
Ewa Sitarska, Junjie Xu, Seungmee Park, Xiaoxia Liu, Bradley Quade, Karolina Stepien, Kyoko Sugita, Chad A Brautigam, Shuzo Sugita, Josep Rizo
Publikováno v:
eLife, Vol 6 (2017)
Munc18-1 orchestrates SNARE complex assembly together with Munc13-1 to mediate neurotransmitter release. Munc18-1 binds to synaptobrevin, but the relevance of this interaction and its relation to Munc13 function are unclear. NMR experiments now show
Externí odkaz:
https://doaj.org/article/ff1c5e9989384ec782f9768b36af6d1a
Publikováno v:
eLife, Vol 6 (2017)
The GIPC family adaptor proteins mediate endocytosis by tethering cargo proteins to the myosin VI motor. The structural mechanisms for the GIPC/cargo and GIPC/myosin VI interactions remained unclear. PlexinD1, a transmembrane receptor that regulates
Externí odkaz:
https://doaj.org/article/d26808970e41473fb66af8181743be32
Autor:
Sushama Sivakumar, Paweł Ł Janczyk, Qianhui Qu, Chad A Brautigam, P Todd Stukenberg, Hongtao Yu, Gary J Gorbsky
Publikováno v:
eLife, Vol 5 (2016)
The spindle- and kinetochore-associated (Ska) complex is essential for normal anaphase onset in mitosis. The C-terminal domain (CTD) of Ska1 binds microtubules and was proposed to facilitate kinetochore movement on depolymerizing spindle microtubules
Externí odkaz:
https://doaj.org/article/b9e3beb34c044d49830a9befa8858711