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A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

Autor: Zhu, Lucía, Retana, Diana, García‐Gómez, Pedro, Álvaro‐Espinosa, Laura, Priego, Neibla, Masmudi‐Martín, Mariam, Yebra, Natalia, Miarka, Lauritz, Hernández‐Encinas, Elena, Blanco‐Aparicio, Carmen, Martínez, Sonia, Sobrino, Cecilia, Ajenjo, Nuria, Artiga, Maria‐Jesus, Ortega‐Paino, Eva, Torres‐Ruiz, Raúl, Rodríguez‐Perales, Sandra, Soffietti, Riccardo, Bertero, Luca, Cassoni, Paola, Weiss, Tobias, Muñoz, Javier, Sepúlveda, Juan Manuel, González‐León, Pedro, Jiménez‐Roldán, Luis, Moreno, Luis Miguel, Esteban, Olga, Pérez‐Núñez, Ángel, Hernández‐Laín, Aurelio, Toldos, Oscar, Ruano, Yolanda, Alcázar, Lucía, Blasco, Guillermo, Fernández‐Alén, José, Caleiras, Eduardo, Lafarga, Miguel, Megías, Diego, Graña‐Castro, Osvaldo, Nör, Carolina, Taylor, Michael D, Young, Leonie S, Varešlija, Damir, Cosgrove, Nicola, Couch, Fergus J, Cussó, Lorena, Desco, Manuel, Mouron, Silvana, Quintela‐Fandino, Miguel, Weller, Michael, Pastor, Joaquín, Valiente, Manuel, de la Lama‐Zaragoza, Adolfo, Calero‐Felix, Lourdes, Fiaño‐Valverde, Concepcion, Delgado‐López, Pedro David, Montalvo‐Afonso, Antonio, Pascual‐Llorente, Mar, Díaz‐Piqueras, Ángela, Nam‐Cha, SH, Barrena López, Cristina, Plans Ahicart, Gerard, Martínez‐Saez, Elena, Ramón y Cajal, Santiago, Nicolás, Pilar

Publikováno v: EMBO Mol Med . 2022 Mar 7;14(3):e14552
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)

We report a medium-throughput drug-screening platform (METPlatform) based on organotypic cultures that allows to evaluate inhibitors against metastases growing in situ. By applying this approach to the unmet clinical need of brain metastasis, we iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68da1cd2b2d2fed8202f42b77edc896d
https://hdl.handle.net/10016/37287

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Modeling space preferences for accurate occupancy prediction during the design phase

Autor: Cha, SH, Steemers, K, Kim, TW

The accurate prediction of occupancy during the design phase of a building helps architects to improve space efficiency by eliminating the possible under-utilization and over-crowding of space during the design use phase. However, existing models exh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb781b86fc021907871b3717f358b397

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PC-Based 3D Reconstruction of MR Angiography in Evaluation of Intracranial Aneurysms

Autor: Moon Hee Han, Chang Kh, Baik Sk, Park Sw, Kyung-Hee Kim, Bae Ju Kwon, Kwon Ok, Cha Sh

Publikováno v: Interventional Neuroradiology. 8:169-181

In this study, we present our experiences of personal computer-based 3D reconstructions of MRA for pre-treatment planning and post-treatment follow-up for cerebral aneurysms. Twenty-nine ruptured or unruptured intracranial aneurysm patients with 36 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bf8d10b9c80e79dc7812b943494a79
https://doi.org/10.1177/159101990200800209

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Moyamoya disease presenting with singing induced chorea

Autor: Kim Yg, Chung Sy, Han Sh, Cha Sh

Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 69:833-834

Moyamoya disease is a relatively uncommon, chronic cerebral vasculopathy of unknown aetiology that is characterised by unilateral or bilateral stenosis or occlusion of the proximal portion of the carotid arteries, together with an abnormal vascular n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85df5743cc15b0473ed080462449fd3a
https://doi.org/10.1136/jnnp.69.6.833

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