Inhibitory Regulation of FOXO1 in PPARδ Expression Drives Mitochondrial Dysfunction and Insulin Resistance.

Autor: Park S; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Republic of Korea.; Senotherapy-Based Metabolic Diseases Control Research Center, College of Medicine, Yeungnam University, Daegu, Republic of Korea., Cha HN; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Republic of Korea.; Senotherapy-Based Metabolic Diseases Control Research Center, College of Medicine, Yeungnam University, Daegu, Republic of Korea., Shin MG; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Republic of Korea., Park S; Department of Molecular Medicine, College of Medicine, Gachon University, Incheon, Republic of Korea., Kim Y; Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology, Gachon University, Incheon, Republic of Korea., Kim MS; Department of Fundamental Environment Research, Environmental Measurement and Analysis Center, National Institute of Environmental Research, Incheon, Republic of Korea., Shin KH; Department of Marine Sciences and Convergent Technology, Hanyang University, Ansan, Republic of Korea., Thoudam T; Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea., Lee EJ; Department of Medical Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea., Wolfe RR; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR., Dan J; Department of Orthopedic Surgery, College of Medicine, CHA University, Gumi, Republic of Korea., Koh JH; Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea., Kim IY; Department of Molecular Medicine, College of Medicine, Gachon University, Incheon, Republic of Korea., Choi I; Department of Medical Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea., Lee IK; Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea.; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea., Sung HK; The Hospital for Sick Children Research Institute & Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Park SY; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Republic of Korea.; Senotherapy-Based Metabolic Diseases Control Research Center, College of Medicine, Yeungnam University, Daegu, Republic of Korea.

Publikováno v: Diabetes [Diabetes] 2024 Jul 01; Vol. 73 (7), pp. 1084-1098.

Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells.

Autor: Moon JH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea.; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea., Lee J; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Kim KH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea.; Biomedical Research Center, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea., Kim HJ; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea., Kim H; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea.; Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, Korea., Cha HN; Department of Physiology, College of Medicine, Yeongnam University, Daegu, Korea., Park J; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea., Lee H; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea., Park SY; Department of Physiology, College of Medicine, Yeongnam University, Daegu, Korea., Jang HC; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea. janghak@snu.ac.kr., Kim H; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea. hailkim@kaist.edu.; Biomedical Research Center, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea. hailkim@kaist.edu.

Publikováno v: Experimental & molecular medicine [Exp Mol Med] 2023 Oct; Vol. 55 (10), pp. 2269-2280. Date of Electronic Publication: 2023 Oct 31.

Inhibiting serotonin signaling through HTR2B in visceral adipose tissue improves obesity-related insulin resistance.

Autor: Choi WG; Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST, Daejeon, South Korea., Choi W; Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST, Daejeon, South Korea.; Department of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, South Korea., Oh TJ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea., Cha HN; Department of Physiology, College of Medicine, Yeungnam University, Daegu, South Korea., Hwang I; Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST, Daejeon, South Korea., Lee YK; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea., Lee SY; Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST, Daejeon, South Korea., Shin H; Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST, Daejeon, South Korea., Lim A; Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST, Daejeon, South Korea., Ryu D; Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea., Suh JM; Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST, Daejeon, South Korea., Park SY; Department of Physiology, College of Medicine, Yeungnam University, Daegu, South Korea., Choi SH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea., Kim H; Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST, Daejeon, South Korea.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2021 Dec 01; Vol. 131 (23).

Selenoprotein W deficiency does not affect oxidative stress and insulin sensitivity in the skeletal muscle of high-fat diet-fed obese mice.

Autor: Shin MG; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea.; Smart-aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea., Cha HN; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea.; Smart-aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea., Park S; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea.; Smart-aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea., Kim YW; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea., Kim JY; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea., Park SY; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea.; Smart-aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea.

Publikováno v: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2019 Dec 01; Vol. 317 (6), pp. C1172-C1182. Date of Electronic Publication: 2019 Sep 11.

Peroxiredoxin2 Deficiency Aggravates Aging-Induced Insulin Resistance and Declines Muscle Strength.

Autor: Cha HN; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea.; Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea., Park S; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea.; Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea., Dan Y; Weinberg College of Art and Sciences, Northwestern University, Chicago, Illinois., Kim JR; Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea.; Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, Korea., Park SY; Department of Physiology, College of Medicine, Yeungnam University, Daegu, Korea.; Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu, Korea.

Publikováno v: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2019 Jan 16; Vol. 74 (2), pp. 147-154.