Chemically Driven Clearance of Amyloid Aggregates by Polyfunctionalized Furo[2,3‑b:4,5‑b′]dipyridine–Chalcone Hybrids to Ameliorate Memory in an Alzheimer Mouse Model.

Autor: Cha, Minhae, Kim, Sunmi, Jung, Euijin, Cho, Illhwan, Park, InWook, Yoon, Soljee, Ye, Suhyun, Lee, Songmin, Kim, JiMin, Kim, Hye Yun, Oh, Ji-Hoon, Maeng, Han-Joo, Kim, Ikyon, Kim, YoungSoo

Publikováno v: Molecular Pharmaceutics; 7/1/2024, Vol. 21 Issue 7, p3330-3342, 13p

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4‑Acyl-3,4-dihydropyrrolo[1,2‑a]pyrazine Derivative Rescued the Hippocampal-Dependent Cognitive Decline of 5XFAD Transgenic Mice by Dissociating Soluble and Insoluble Aβ Aggregates.

Autor: Lee, Songmin, Dagar, Anuradha, Cho, Illhwan, Kim, Kyeonghwan, Park, In Wook, Yoon, Soljee, Cha, Minhae, Shin, Jisu, Kim, Hye Yun, Kim, Ikyon, Kim, YoungSoo

Publikováno v: ACS Chemical Neuroscience; 6/7/2023, Vol. 14 Issue 11, p2016-2026, 11p

Chemically Driven Clearance of Amyloid Aggregates by Polyfunctionalized Furo[2,3- b :4,5- b ']dipyridine-Chalcone Hybrids to Ameliorate Memory in an Alzheimer Mouse Model.

Autor: Cha M, Kim S, Jung E, Cho I, Park I, Yoon S; Department of Integrative Biotechnology & Translational Medicine, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Republic of Korea., Ye S, Lee S, Kim J, Kim HY, Oh JH; College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Republic of Korea., Maeng HJ; College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Republic of Korea., Kim I, Kim Y; Department of Integrative Biotechnology & Translational Medicine, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Republic of Korea.; Amyloid Solution, Seongnam-si 13486, Gyeonggi-do, Republic of Korea.; Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2024 Jul 01; Vol. 21 (7), pp. 3330-3342. Date of Electronic Publication: 2024 Jun 14.