Zobrazeno 1 - 10
of 6 964
pro vyhledávání: '"ChIP-Seq"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Transcription factors (TFs) bind to DNA in a highly sequence-specific manner. This specificity manifests itself in vivo as differences in TF occupancy between the two alleles at heterozygous loci. Genome-scale assays such as ChIP-
Externí odkaz:
https://doaj.org/article/203b6acd35344567af1a6e1d3e57ec39
Autor:
Zhongyao Chen, Qiang Gao, Yukui Shang, Behzad Nasiri Ahmadabadi, Yawei Hu, Wei Zhang, Peng Liu
Publikováno v:
hLife, Vol 2, Iss 9, Pp 471-487 (2024)
Diffuse midline glioma (DMG), H3K27-altered, is lethal pediatric-type, high-grade, localized to the midline region of the central nervous system. Effective treatment guidelines are absent, and clinical trials are preferred for primary or recurrent DM
Externí odkaz:
https://doaj.org/article/ec2b8c3e14d849329f83bfc493b44ce0
Autor:
Marie-Océane Laguillaumie, Sofia Titah, Aurélie Guillemette, Bernadette Neve, Frederic Leprêtre, Pascaline Ségard, Faruk Azam Shaik, Dominique Collard, Jean-Claude Gerbedoen, Léa Fléchon, Lama Hasan Bou Issa, Audrey Vincent, Martin Figeac, Shéhérazade Sebda, Céline Villenet, Jérôme Kluza, William Laine, Isabelle Fournier, Jean-Pascal Gimeno, Maxence Wisztorski, Salomon Manier, Mehmet Cagatay Tarhan, Bruno Quesnel, Thierry Idziorek, Yasmine Touil
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-28 (2024)
Abstract Background Tumour dormancy, a resistance mechanism employed by cancer cells, is a significant challenge in cancer treatment, contributing to minimal residual disease (MRD) and potential relapse. Despite its clinical importance, the mechanism
Externí odkaz:
https://doaj.org/article/a30941614df749d1805f6f87c1b51f5b
Autor:
Leonor Schubert Santana, Alejandro Reyes, Sebastian Hoersch, Enrico Ferrero, Christian Kolter, Swann Gaulis, Sebastian Steinhauser
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2190-2199 (2024)
Spatiotemporal regulation of gene expression is controlled by transcription factor (TF) binding to regulatory elements, resulting in a plethora of cell types and cell states from the same genetic information. Due to the importance of regulatory eleme
Externí odkaz:
https://doaj.org/article/b389b0582e8748f19a3f095d7b02a90d
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract Background Reproducibility is a major concern in biomedical studies, and existing publication guidelines do not solve the problem. Batch effects and quality imbalances between groups of biological samples are major factors hampering reproduc
Externí odkaz:
https://doaj.org/article/6b9e7e93a0ba48129d1e4647399be59c
Autor:
Yi Wang, Shuwen Chen, Min Xue, Jinhu Ma, Xinrui Yi, Xinyu Li, Xuejin Lu, Meizi Zhu, Jin Peng, Yunshu Tang, Yaling Zhu
Publikováno v:
Animal Bioscience, Vol 37, Iss 8, Pp 1317-1332 (2024)
Objective Rare study of the non-coding and regulatory regions of the genome limits our ability to decode the mechanisms of fatty liver hemorrhage syndrome (FLHS) in chickens. Methods Herein, we constructed the high-fat diet-induced FLHS chicken model
Externí odkaz:
https://doaj.org/article/ed39f2ac5f104c6b93c7b5e5225f148b
Publikováno v:
陆军军医大学学报, Vol 46, Iss 14, Pp 1666-1675 (2024)
Objective To analyze the genome-wide profiles of H3K9 crotonylation (H3K9cr) in mouse embryonic stem cells (mESCs) in normal or deficient folic acid (FA) by chromatin immunoprecipitation sequencing (ChIP-seq) in order to observe the genome-wide chang
Externí odkaz:
https://doaj.org/article/b9a1a399944f408fad3abfe4451afb81
Autor:
Dandan Wu, Chi Yang, Yanfang Yao, Dongmei Ma, Hong Lin, Ling Hao, Wenwen Xin, Kangfu Ye, Minghui Sun, Yule Hu, Yanling Yang, Zhenhong Zhuang
Publikováno v:
eLife, Vol 13 (2024)
The epigenetic reader SntB was identified as an important transcriptional regulator of growth, development, and secondary metabolite synthesis in Aspergillus flavus. However, the underlying molecular mechanism is still unclear. In this study, by gene
Externí odkaz:
https://doaj.org/article/c50e77ec04a44b678d59915f03b05488
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-9 (2024)
Abstract Background Standard ChIP-seq and RNA-seq processing pipelines typically disregard sequencing reads whose origin is ambiguous (“multimappers”). This usual practice has potentially important consequences for the functional interpretation o
Externí odkaz:
https://doaj.org/article/c23a305f5fc44abda5e7bcade8ea4200
Autor:
Sonalí Harris, Iqra Anwar, Syeda S. Baksh, Richard E. Pratt, Victor J. Dzau, Conrad P. Hodgkinson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract In a previous report, we demonstrated that Cbx1, PurB and Sp3 inhibited cardiac muscle differentiation by increasing nucleosome density around cardiac muscle gene promoters. Since cardiac and skeletal muscle express many of the same proteins
Externí odkaz:
https://doaj.org/article/090c31b4b9ad4fe3b9b2138540c91f34