Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ch. M. Leijdekkers"'
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 130:153-158
Several fractions of creosote P1 separated by TLC showed mutagenicity towards Salmonella typhimurium TA98. Thus mutagenicity is probably caused by the presence of mutagenic aromatic hydrocarbons. The mutagenic polycyclic aromatic hydrocarbons, benzo[
Autor:
J. Mooy, Margot J. H. de Reus, G. R. Mohn, Ch. M. Leijdekkers, J. Van Harten, H. J. M. Salden, J. G. Loeber, M. Raghoebar, R. J. M. ten Berge, Joop S. de Graaf, W. de Jong, E. M. van der Beek, C. A. M. Van Ginneken, P. W. Wester, J. B. M. van Driel, Peter M. Edelbroek, Hans Rollema, C. A. J. M. Vulders, D. J. Touw, J. J. Grote, Pramod R. Saxena, E. I. Krajnc, Frans P. Nijkamp, J. Kreukniet, Frederik A. de Wolff, H. Burbach, F. C. Hillen, W. Kruizinga, F. W. J. Gribnau, P. H. Hofman, M. J. A. M. Franssen, K. H. Rahn, Frans G. M. Russel, Hans J. Steenbergen, E. Laban, D.J. de Wildt, H. Wollersheim, Npe Vermeulen, H. M. E. Scheres, M. Van Der Graaff, L. R. Remeyer, E. Ronald de Kloet, M. C. M. Rijk, H. J. H. Salden, F. J. Jongeneelen, Theo Mulder, H. E. Sluiter, T. Bultsma, A. B. M. Klaassen, M. v. Baak, J. A. H. Raaijmakers, A. J. van Rozen, J. F. M. Nouws, R. A. P. Koene, N. Verbeke, H. L. G. H. Tiemessen, B. J. L. Kothuis, Cor J. de Vos, R.P. Bos, J. G. P. Peters, Frans W. H. M. Merkus, C. E. M. Zoetemelk, Mjmc Thoolen, M. R. Linschoten, P. T. A. Schellekens, W. Buijs, Th. Thien, H. Th. M. Folgering, L. Conings, D. K. F. Meijer, J. J. Cox van Put, J. De Gier, Ferdi Engels, W. Kateman, P. Lomax, F. Th. M. Huysmans, F. X. R. van Leeuwen, C. J. Van Boxtel, Y. Tan, M. J. Krielaart, G. A. Charbon, J. G. Vos, B. J. 't Hart, J. Jelinek, P. van Heuven-Nolsen, W. J. Wijnands, A. de Jonge, G. R. Bolt, U. R. Tjaden, K. U. Leuven, Durk Oijkstra, Lambert H.M. Janssen, C. M. M. Veldhoven, H. M. N. Nievelstein, E. J. AriËns, H. M. J. Roelofs, A. van 't Laar, L. H. van den Berg, H. N. Doods, F. Corstens, M. v. Hengstum, O. Driessen, R. Groothedde, G. B. van der Voet, W. Kuijpers, A. de Klerk, E. Schönbaum, D. D. Breimer, B. van Ommen, C. A. van der Heijden, M. v. Hooff, E. A. De Bruijn, Hendrik Timmerman, L. C. M. Baars, P van Brummelen, C. T. A. Evelo, A. J. Beld, H. H. W. Thljssen, G. Aué, R. van Doorn, H. A. M. G. Vaessen, J. Fennis, Theo B.A. Mulder, W. v. d. Broek, G. K. Terpstra, A. T. van Oosterom, Cor J. Grol, R. A. Lefebvre, P. A. Van Zwieten, A. C. Wouterse, Rob B. M. Anzion, J. F. Rodrigues De Miranda, C. Neef, R. S. Oosting, A. Van Der Gen, C. H. Kleinbloesem, Marian W. Tijhuis, Yechiel A. Hekster, H. A. J. Struyker Boudier, C. L. A. van Herwaarden, Bob Wilffert, Dora Mastebroex, E. A. van der Velde, A. S. P. M. Breed, H. L. M. Siero, Gerard van Aalst, J. L. G. Theuws, F. A. De Wolff, J. Rozing, E. I. Krajc, R. H. B. Meyboom, M. A. M. ten Broeke, J. Festen, P.J.L. van Gemert, A. P. I. Jzerman, Hans Wynberg, Alan Horn, H. J. E. Reeuwijk, B. O Osterhuis, R. Dorlas, P. A. M. Peeters, J. Willemsen, L. M. de Brauw, Jan B. de Vries, L. B. A. van de Putte, Alan S. Horn, J. H. Canton, H. J. E. M. Reeuwijk, M. Schols, J. A. M. Raaijmakers, Marcus Bogaert, J. van Noordwijk, Durk Dijkstra, P.Th. Henderson, Peter P. Koopmans, J. W. J. Lammers, T. B. Vree, C. J. H. van de Velde, C. J. Van Koppen, Bernard Hazelhoff, Jaap Wilting, H. M. Pinedo, W. Kuypers, C. M. Ruland, H. A. J. Struyker-Boudier, J. M. Neis, P. B. M. W. M. Timmermans, H. O. Kalkman, P. R. M. Kerklaan, P. A. F. Jansen, J. Peter, J. H. Koeman, H. J. Huidekoper, Mj Mathy, A.F. De Schaepdryver, R.A.M. van der Hoeven, Jos F.M. Smits, Tjeerd van den Berg, E. H. den Tonkelaar, J. W. M. Lenders, P. Sandor, C. A. v. d. Heijden, G. A. Wassink, O. Castelein, P. H. Th. J. Slee
Publikováno v:
Pharmaceutisch Weekblad. 6:163-184
Publikováno v:
Archives of Environmental Health: An International Journal. 36:289-297
Metabolites of carbon disulfide excreted into the urine of viscose workers are detectable by application of a nonselective assay for the determination of thio compounds. Enhanced secretion of thio compounds occurred especially at the end of the workd
Excretion of 3-hydroxy-benzo(a)pyrene and mutagenicity in rat urine after exposure to benzo(a)pyrene
Publikováno v:
Journal of Applied Toxicology. 5:277-282
3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 mumol kg-1. The procedure for the determination of 3-OH-B(a)P con
Publikováno v:
International Archives of Occupational and Environmental Health. 57:47-55
A method for isolating 1-hydroxypyrene from urine is described. The presence of 1-hydroxypyrene in urine was identified by fluorescence excitation and emission scanning after HPLC-separation. 1-Hydroxypyrene could be detected in the urine of rats fol
Autor:
P. T. Henderson, K. Halm, R.M.E. Brouns, Frans J. Jongeneelen, Hubert Dirven, Ch. M. Leijdekkers
Publikováno v:
Journal of Analytical Toxicology. 11:100-104
An HPLC method for the determination of S-phenyl-N-acetylcysteine in urine is described. The sensitivity is 6 mumol/L (CV = 9%) urine. Exposure of rats to six different concentrations of benzene, ranging from 0-30 ppm, was highly associated with urin
Publikováno v:
Occupational and Environmental Medicine. 38:187-190
Thioether concentrations were determined in urine samples obtained from ten workers in the despatch department (n = 69), three chemical waste incinerator operators (n = 67), and an analyst (n = 21), all working in the same chemical plant. Urine sampl
Autor:
T. J. van Bergen, P. J. A. Borm, J. Reuvers, R. van Doorn, Ch. M. Leijdekkers, P.Th. Henderson
Publikováno v:
International archives of occupational and environmental health. 46(2)
Methyl chloride is used as a methylating agent and as a blowing agent in industrial processes. Alkylating agents and other electrophilic compounds are often detoxified in the organism through conjugation with glutathione. Glutathione conjugates are g
Publikováno v:
Toxicology. 11(3)
Summary Administration of phorone (diisopropylidene acetone), an industrial solvent, to mice caused a rapid depletion of hepatic glutathione, which is due to enzymatic conjugation of phorone with glutathione, mediated by cytoplasmic enzymes of the li
Publikováno v:
Toxicology letters. 12(1)
2-Thiothiazolidine-4-carboxylic acid (TTCA) was measured in urine of two persons given an oral dose of 250 mg disulfiram. Maximum concentrations up to 0.33 mmol TTCA/mol creatinine were found, 10 to 14 h after dosing. The total amounts of TTCA excret