Targeting Epidermal Growth Factor Receptor in Solid Tumors: Critical Evaluation of the Biological Importance of Therapeutic Monoclonal Antibodies

Autor: D. Kletsas, Haralabos P. Kalofonos, Dimitris Mavroudis, Ch. Gialeli, Nikos K. Karamanos, G. N. Tzanakakis

Publikováno v: Current Medicinal Chemistry. 16:3797-3804

Numerous cellular pathways have a significant impact in the growth and metastatic potential of tumors. Essential element of such pathways is the epidermal growth factor receptor (EGFR), a member of the HER family of receptor tyrosine kinases. One of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b1e8370559581f288280a9b0272601
https://doi.org/10.2174/092986709789177984

Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab

Autor: G. N. Tzanakakis, Nikos K. Karamanos, Ch. Gialeli, Dimitris Kletsas, Achilleas D. Theocharis

Publikováno v: Investigational new drugs. 31(3)

The epidermal growth factor receptor (EGFR) is a member of the HER family receptors and its activation induced by its natural ligand EGF results in colon cancer growth and progression. Panitumumab (pmAb) is a fully human IgG2 anti-EGFR antibody that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78217c8f19191cb537e0c609471e5f8
https://pubmed.ncbi.nlm.nih.gov/22956286

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Dynamic interplay between breast cancer cells and normal endothelium mediates the expression of matrix macromolecules, proteasome activity and functional properties of endothelial cells.

Autor: Gialeli Ch; Biochemistry, Biochemical Analysis & Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26110 Patras, Greece; Foundation for Research and Technology, Institute of Chemical Engineering Sciences (FORTH/ICE-HT), 26500 Patras, Greece., Viola M; Department of Surgery and Morphological Sciences, University of Insubria, Varese, Italy., Barbouri D; Biochemistry, Biochemical Analysis & Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26110 Patras, Greece; Foundation for Research and Technology, Institute of Chemical Engineering Sciences (FORTH/ICE-HT), 26500 Patras, Greece., Kletsas D; Laboratory of Cell Proliferation and Ageing, Institute of Biology, National Center of Scientific Research 'Demokritos', Athens, Greece., Passi A; Department of Surgery and Morphological Sciences, University of Insubria, Varese, Italy., Karamanos NK; Biochemistry, Biochemical Analysis & Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26110 Patras, Greece; Foundation for Research and Technology, Institute of Chemical Engineering Sciences (FORTH/ICE-HT), 26500 Patras, Greece. Electronic address: n.k.karamanos@upatras.gr.

Publikováno v: Biochimica et biophysica acta [Biochim Biophys Acta] 2014 Aug; Vol. 1840 (8), pp. 2549-59. Date of Electronic Publication: 2014 Feb 26.

Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab.

Autor: Gialeli Ch; Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26110, Patras, Greece., Theocharis AD, Kletsas D, Tzanakakis GN, Karamanos NK

Publikováno v: Investigational new drugs [Invest New Drugs] 2013 Jun; Vol. 31 (3), pp. 516-24. Date of Electronic Publication: 2012 Sep 06.