Výsledky vyhledávání - "Ch, Zantwijk"

Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates

Autor: Mg, Rots, Pieters R, Gj, Peters, Ch, Zantwijk, Mauritz R, Noordhuis P, Jc, Willey, Hählen K, Creutzig U, Janka-Schaub G, Gj, Kaspers, Anjo JP Veerman, Jansen G

Publikováno v: Europe PubMed Central

Cellular methotrexate (MTX) resistance may cause treatment failure in childhood common/preB-acute lymphoblastic leukemia (c/preB-ALL), T-lineage ALL (T-ALL), and acute myeloid leukemia (AML). The ex vivo potency of several antifolates (MTX, trimetrex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::43ef8fd9db940a9c50c19b6cf875a006
https://pubmed.ncbi.nlm.nih.gov/10556198

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Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia

Autor: Mg, Rots, Pieters R, Gj, Peters, Noordhuis P, Ch, Zantwijk, Gj, Kaspers, Hählen K, Creutzig U, Anjo JP Veerman, Jansen G

Publikováno v: Europe PubMed Central

Inefficient polyglutamylation is a mechanism of resistance to methotrexate (MTX) in childhood T-lineage acute lymphoblastic leukemia (T-ALL) and in acute myeloid leukemia (AML) in comparison with childhood c/preB-ALL. We analyzed the profile of MTX p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4a96cc5302c45fdd69e2c6746815b218
https://pubmed.ncbi.nlm.nih.gov/10029597

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Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells

Autor: Mauritz R, Mw, Bekkenk, Mg, Rots, Pieters R, Mini E, Ch, Zantwijk, Anjo JP Veerman, Gj, Peters, Jansen G

Publikováno v: Europe PubMed Central

Leukemic cells of 27 children [14 patients with initial acute lymphoblastic leukemia (iALL), 8 patients with relapsed ALL (rALL), and 5 patients with acute nonlymphoblastic leukemia (ANLL)] were evaluated for their sensitivity to methotrexate (MTX) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6a2592e80d5888ccbd5b5cf37cda73ed
https://pubmed.ncbi.nlm.nih.gov/9796971

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Favorable prognosis of hyperdiploid common acute lymphoblastic leukemia may be explained by sensitivity to antimetabolites and other drugs: results of an in vitro study

Autor: Gj, Kaspers, La, Smets, Pieters R, Ch, Zantwijk, Er, Wering, Anjo JP Veerman

Publikováno v: Europe PubMed Central

DNA hyperdiploidy is a favorable prognostic factor in childhood acute lymphoblastic leukemia (ALL). The explanation for this prognostic significance is largely unknown. We have studied whether DNA ploidy was related to cellular resistance to 12 drugs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::409fd3b5141af482d222148932d53a8a
https://pubmed.ncbi.nlm.nih.gov/7833478

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Peanut agglutinin, a marker for T-cell acute lymphoblastic leukemia with a good prognosis

Autor: Anjo JP Veerman, Ph, Hogeman, Dr, Huismans, Ch, Zantwijk, Pd, Bezemer

Publikováno v: Europe PubMed Central

Peanut agglutinin (PNA) binding was studied in cells from 74 children with acute lymphoblastic leukemia (ALL). PNA positivity occurred in 50% of T-ALL (12 of 24) and was rare in other types of ALL. There was no clear relationship between PNA and init

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ad5bbac8b3d1767d68b6c57f43d0ef43
https://pubmed.ncbi.nlm.nih.gov/3872169

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In vitro cellular drug resistance and prognosis in newly diagnosed childhood acute lymphoblastic leukemia

Autor: Gj, Kaspers, Anjo JP Veerman, Pieters R, Ch, Zantwijk, La, Smets, Er, Wering, Van Der Does-Van Den Berg A

Publikováno v: Europe PubMed Central

As an important determinant of the response to chemotherapy, measurements of cellular drug resistance may provide prognostically significant information, which could be useful for optimal risk-group stratification. The objective of this report is to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8c5cd82c19e9212f348e21501008a9f1
http://europepmc.org/abstract/med/9326239

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Differential methotrexate resistance in childhood T- versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition assay, but not by the MTT assay

Autor: Mg, Rots, Pieters R, Gj, Kaspers, Ch, Zantwijk, Noordhuis P, Mauritz R, Anjo JP Veerman, Jansen G, Gj, Peters

Publikováno v: Europe PubMed Central

Methotrexate (MTX) is not cytotoxic to patient-derived acute lymphoblastic leukemia (ALL) cells in total-cell-kill assays, such as the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, putatively due to the rescue effects of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a709a96b8a6dd79563eafabe80bc0f61
http://europepmc.org/abstract/med/9920857

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Prognostic significance of peanut agglutinin binding in childhood acute lymphoblastic leukemia

Autor: Gj, Kaspers, Anjo JP Veerman, Er, Wering, Be, Linden-Schrever, Ch, Zantwijk, Van Der Does-Van Den Berg A, Pieters R

Publikováno v: Europe PubMed Central

We previously reported the favorable prognosis associated with positive peanut agglutinin (PNA) binding in childhood T cell acute lymphoblastic leukemia (ALL), and hypothesized that this may be related to glucocorticoid sensitivity (Veerman et al. Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1d912e79c54faf4e8e665e20f7e2d93c
http://europepmc.org/abstract/med/8618446

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