Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Cezar M Tigaret"'
Autor:
Marzia Indrigo, Ilaria Morella, Daniel Orellana, Raffaele d'Isa, Alessandro Papale, Riccardo Parra, Antonia Gurgone, Daniela Lecca, Anna Cavaccini, Cezar M Tigaret, Alfredo Cagnotto, Kimberley Jones, Simon Brooks, Gian Michele Ratto, Nicholas D Allen, Mariah J Lelos, Silvia Middei, Maurizio Giustetto, Anna R Carta, Raffaella Tonini, Mario Salmona, Jeremy Hall, Kerrie Thomas, Riccardo Brambilla, Stefania Fasano
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Cell signaling is central to neuronal activity and its dysregulation may lead to neurodegeneration and cognitive decline. Here, we show that selective genetic potentiation of neuronal ERK signaling prevents cell death in vitro and in vivo in
Externí odkaz:
https://doaj.org/article/07ec956f4df240a18ad3746f40460254
Publikováno v:
eLife, Vol 12 (2023)
Discovering the rules of synaptic plasticity is an important step for understanding brain learning. Existing plasticity models are either (1) top-down and interpretable, but not flexible enough to account for experimental data, or (2) bottom-up and b
Externí odkaz:
https://doaj.org/article/a333dbddecff47a99c9637ccf9172bd0
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated
Externí odkaz:
https://doaj.org/article/9f9d787105724ad4af6f572861d5bab0
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 8 (2016)
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input
Externí odkaz:
https://doaj.org/article/a95b74311c964fc6abcd7507635562c3
Discovering the rules of synaptic plasticity is an important step for understanding brain learning. Existing plasticity models are either 1) top-down and interpretable, but not flexible enough to account for experimental data, or 2) bottom-up and bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e8eb004aa7c50c1f4495d16a2bb8fb
https://hal.archives-ouvertes.fr/hal-03259012
https://hal.archives-ouvertes.fr/hal-03259012
Autor:
Michael John Owen, Michael Conlon O'Donovan, Edward R. Morrell, Lucy Sykes, Tzu-Ching E. Lin, Kerrie L. Thomas, Lawrence Stephen Wilkinson, Cezar M. Tigaret, Jeremy Hall, Matt Jones
Genetic variation in CACNA1C, which encodes the alpha-1 subunit of CaV1.2 L-type voltage-gated calcium channels, is strongly linked to risk for psychiatric disorders including schizophrenia and bipolar disorder. To translate genetics to neurobiologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12a11f73e7c0be4d708e0bee23407b1b
https://doi.org/10.1101/2020.05.29.123695
https://doi.org/10.1101/2020.05.29.123695
Autor:
Jeremy Hall, Cezar M. Tigaret, Sophie E.L. Chamberlain, Michael C. Ashby, Joseph H.L.P. Sadowski, Jack R. Mellor
Publikováno v:
Tigaret, C M, Chamberlain, S E L, Sadowski, J H L, Hall, J, Ashby, M & Mellor, J 2018, ' Convergent Metabotropic Signaling Pathways Inhibit SK Channels to Promote Synaptic Plasticity in the Hippocampus ', Journal of Neuroscience, vol. 38, no. 43, pp. 9252-9262 . https://doi.org/10.1523/JNEUROSCI.1160-18.2018
The Journal of Neuroscience
The Journal of Neuroscience
Hebbian synaptic plasticity at hippocampal Schaffer collateral synapses is tightly regulated by postsynaptic small conductance (SK) channels that restrict NMDA receptor activity. SK channels are themselves modulated by G-protein-coupled signaling pat
Autor:
Stefania Fasano, Anna Cavaccini, Daniela Lecca, Maurizio Giustetto, Raffaella Tonini, Silvia Middei, Riccardo Parra, Alessandro Papale, Cezar M. Tigaret, Riccardo Brambilla, Jeremy Hall, Simon Philip Brooks, Ilaria Morella, Gian Michele Ratto, Daniel Orellana, Anna R. Carta, Marzia Indrigo, Antonia Gurgone, Raffaele d’Isa, Kerrie L. Thomas
Cell signalling mechanisms are central to neuronal activity and their dysregulation may lead to neurodegenerative processes and associated cognitive decline. So far, a major effort has been directed toward the dissection of disease specific pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af9d60e817eae877f09bcd1256fc742
Autor:
Barbara Imperiali, Kevin Thiolon, Christelle Breillat, Nelson B. Olivier, Christel Poujol, Lucie Bard, Matthieu Sainlos, Daniel Choquet, Cezar M. Tigaret
Publikováno v:
Nature Chemical Biology
The interactions of the AMPA receptor (AMPAR) auxiliary subunit Stargazin with PDZ domain-containing scaffold proteins such as PSD-95 are critical for the synaptic stabilization of AMPARs. To investigate these interactions, we have developed biomimet
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(12)
Membrane trafficking of AMPA receptors (AMPARs) is critical for neuronal function and plasticity. Although rapid forms of AMPAR internalization during long-term depression (LTD) require clathrin and dynamin, the mechanisms governing constitutive AMPA