Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ceusters Marc Andre"'
Autor:
Jan de Hoon, Anja Hijzen, Sofie Celen, Luc Van Nueten, Donatienne Van Weehaeghe, Koen Van Laere, Corinne Vandermeulen, Guy Bormans, Michel Koole, Kim Serdons, Ceusters Marc Andre, Wei Zhang, Paulien Ravenstijn, Mark E. Schmidt, Hartmuth C. Kolb
Publikováno v:
Journal of Nuclear Medicine. 60:683-690
The P2X7 receptor (P2X7R) is an adenosine triphosphate-gated ion channel that is predominantly expressed on microglial cells in the central nervous system. We report the clinical qualification of P2X7-specific PET ligand 18F-JNJ-64413739 in healthy v
Autor:
Nuria García-Magro, Anindya Bhattacharya, Antonio G. García, Ceusters Marc Andre, Cristina Ruiz-Ruiz, Carlos Avendaño, Pilar Negredo
Publikováno v:
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 13, Iss 10 (2020)
article-version (VoR) Version of Record
Universidad Autónoma de Madrid
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 13, Iss 10 (2020)
article-version (VoR) Version of Record
Neuroinflammation is one of the main physiopathological mechanisms of amyotrophic lateral sclerosis (ALS), produced by the chronic activation of microglia in the CNS. This process is triggered by the persistent activation of the ATP-gated P2X7 recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824e0cfdb46fa97f8647009b69778b0c
http://hdl.handle.net/10486/695520
http://hdl.handle.net/10486/695520
Autor:
Alan D. Wickenden, Monicah A. Otieno, Jimmy T. Liang, Stewart Bryant, Michael A. Letavic, Ian Fraser, Derek A. Beauchamp, Nicholas I. Carruthers, Devin M. Swanson, Christine F. Gelin, Curt A. Dvorak, Meri De Angelis, Ceusters Marc Andre, Hong Ao, Anindya Bhattacharya, Brian Lord, Tatiana Koudriakova, Allison Brett Douglas, Pascal Bonaventure, Brad M. Savall, Kevin J. Coe, Leah Aluisio, Freddy Schoetens, Qi Wang, José Ignacio Andrés, Timothy W. Lovenberg
Publikováno v:
Journal of Medicinal Chemistry. 60:4559-4572
The synthesis and preclinical characterization of novel 4-(R)-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridines that are potent and selective brain penetrant P2X7 antagonists are described. Optimization efforts based on previously disclosed unsubstitute
Publikováno v:
Neuropsychopharmacology
Autor:
Ceusters Marc Andre, Jeike Biewenga, Paulien Ravenstijn, Luc Van Nueten, Sandy Van Hemelryck, Maarten Timmers, Liwen Xi, Anindya Bhattacharya, Maarten van den Boer, Maura L. Furey, Peter de Boer, Gallen Triana-Baltzer
Publikováno v:
Journal of psychopharmacology
Background: Central nervous system-derived interleukin-1β plays a role in mood disorders. P2X7 receptor activation by adenosine-triphosphate leads to the release of interleukin-1β. Aims: This first-in-human study evaluated safety, tolerability, pha
Autor:
Pilar Lim, Ceusters Marc Andre, Justine M. Kent, Peter de Boer, Wayne C. Drevets, Ella Daly, Rosanne Lane, Luc Van Nueten, Heidi De Smedt, Iva Kezic
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 67:66-73
This phase 2a, randomized, multicenter, double-blind, proof-of-concept study was designed to evaluate, efficacy, safety and tolerability of JNJ-40411813/ADX71149, a novel metabotropic glutamate 2 receptor positive allosteric modulator as an adjunctiv
Autor:
Stefan Pype, Ceusters Marc Andre, Misty D. Smith, Hilde Lavreysen, H. Steve White, Brian D. Klein, Twyman Roy E, Nancy Van Osselaer, Cameron S. Metcalf
Publikováno v:
Epilepsia. 59(3)
Objective We previously demonstrated that positive allosteric modulators (PAMs) of metabotropic glutamate subtype 2 (mGlu2 ) receptors have potential synergistic interactions with the antiseizure drug levetiracetam (LEV). The present study utilizes i
Autor:
Laura Pérez-Benito, Encarnación Matesanz, Aránzazu García, Claire Mackie, Wilhelmus Drinkenburg, Marijke Somers, Luc Peeters, Gregor James Macdonald, Gary Tresadern, Andrés A. Trabanco, Juan Antonio Vega, Ana Isabel de Lucas, Hilde Lavreysen, Ceusters Marc Andre, Laura Iturrino, Daniel Oehlrich, María Lourdes Linares, Alcira del Cerro, José María Cid, A. Ahnaou
Publikováno v:
Journal of medicinal chemistry. 59(18)
Positive allosteric modulators of the metabotropic glutamate 2 receptor have generated great interest in the past decade. There is mounting evidence of their potential as therapeutic agents in the treatment of multiple central nervous system disorder
Autor:
Ceusters Marc Andre, Krystyna Szewczyk, Halima Amhaoul, Stefanie Dedeurwaerdere, Samir Kumar-Singh, Idrish Ali, Marco Mola, Stephan Missault, Annemie Van Eetveldt, Kenny Bielen, Anindya Bhattacharya, Brian Lord, Jason C. Rech
Publikováno v:
Neuropharmacology
Background The available pharmacotherapy for patients with epilepsy primarily address the symptoms and are ineffective in about 40% of patients. Brain inflammation gained support as potential target for developing new therapies, especially the P2X7 r
Autor:
Ceusters Marc Andre, Jolanta Dyniewicz, Marta Bochynska, Steven Ballet, Attila Keresztes, Cecilia Betti, Barbara Przewlocka, Peter W. Schiller, Joanna Mika, Dirk Tourwé, Andrzej W. Lipkowski, Francois Maria Sommen, Joost Van Duppen, Piotr Kosson, Theo Meert, Nga N. Chung, Lukasz Frankiewicz, Alexandre Novoa, Wioletta Makuch, Frans Eduard Janssens, Jozef Vanden Broeck, Joanna Starnowska
Herein, the synthesis and biological evaluation of dual opioid agonists-neurokinin 1 receptor (NK1R) antagonists is described. In these multitarget ligands, the two pharmacophores do not overlap, and this allowed maintaining high NK1R affinity and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d698ae89d3bccddd59f9418e2db539fd
https://europepmc.org/articles/PMC4677362/
https://europepmc.org/articles/PMC4677362/