Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Cesare M, Terracciano"'
Autor:
Fotios G. Pitoulis, Jacob J. Smith, Blanca Pamias‐Lopez, Pieter P. deTombe, Danika Hayman, Cesare M. Terracciano
Publikováno v:
Experimental Physiology, Vol 109, Iss 3, Pp 405-415 (2024)
Abstract Mechanical load is one of the main determinants of cardiac structure and function. Mechanical load is studied in vitro using cardiac preparations together with loading protocols (e.g., auxotonic, isometric). However, such studies are often l
Externí odkaz:
https://doaj.org/article/52b351e93ec747f08bfaf4937f979fb8
Autor:
Raquel Nunez‐Toldra, Thomas Kirwin, Elisa Ferraro, Fotios G. Pitoulis, Laura Nicastro, Ifigeneia Bardi, Worrapong Kit‐Anan, Julia Gorelik, Andre R. Simon, Cesare M. Terracciano
Publikováno v:
ESC Heart Failure, Vol 9, Iss 2, Pp 1400-1412 (2022)
Abstract Aims Altered mechanical load in response to injury is a main driver of myocardial interstitial fibrosis. No current in vitro model can precisely modulate mechanical load in a multicellular environment while maintaining physiological behaviou
Externí odkaz:
https://doaj.org/article/26913f30b9034df698ce567a3d902858
Autor:
Oisín King, Daniela Cruz-Moreira, Alaa Sayed, Fatemeh Kermani, Worrapong Kit-Anan, Ilona Sunyovszki, Brian X. Wang, Barrett Downing, Jerome Fourre, Daniel Hachim, Anna M. Randi, Molly M. Stevens, Marco Rasponi, Cesare M. Terracciano
Publikováno v:
Cell Reports: Methods, Vol 2, Iss 9, Pp 100280- (2022)
Summary: In this study, we report static and perfused models of human myocardial-microvascular interaction. In static culture, we observe distinct regulation of electrophysiology of human induced pluripotent stem cell derived-cardiomyocytes (hiPSC-CM
Externí odkaz:
https://doaj.org/article/69822f4eba4a4455b5192ffcbf3ed217
Autor:
Brian X. Wang, Christopher Kane, Laura Nicastro, Oisín King, Worrapong Kit-Anan, Barrett Downing, Graziano Deidda, Liam S. Couch, Christian Pinali, Anna Mitraki, Kenneth T. MacLeod, Cesare M. Terracciano
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10940 (2022)
Engagement of the sarcoplasmic reticulum (SR) Ca2+ stores for excitation–contraction (EC)-coupling is a fundamental feature of cardiac muscle cells. Extracellular matrix (ECM) proteins that form the extracellular scaffolding supporting cardiac cont
Externí odkaz:
https://doaj.org/article/a0c335a772f34dd3b77998664e203c38
Autor:
Richard J. Jabbour, Thomas J. Owen, Pragati Pandey, Marina Reinsch, Brian Wang, Oisín King, Liam Steven Couch, Dafni Pantou, David S. Pitcher, Rasheda A. Chowdhury, Fotios G. Pitoulis, Balvinder S. Handa, Worrapong Kit-Anan, Filippo Perbellini, Rachel C. Myles, Daniel J. Stuckey, Michael Dunne, Mayooran Shanmuganathan, Nicholas S. Peters, Fu Siong Ng, Florian Weinberger, Cesare M. Terracciano, Godfrey L. Smith, Thomas Eschenhagen, Sian E. Harding
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Engineered heart tissue (EHT) strategies, by combining cells within a hydrogel matrix, may be a novel therapy for heart failure. EHTs restore cardiac function in rodent injury models, but more data are needed in clinically relevant settings. Accordin
Externí odkaz:
https://doaj.org/article/5f7e39207cc8495596ab20ad1eee6e60
Autor:
Samuel A. Watson, James Duff, Ifigeneia Bardi, Magdalena Zabielska, Santosh S. Atanur, Richard J. Jabbour, André Simon, Alejandra Tomas, Ryszard T. Smolenski, Sian E. Harding, Filippo Perbellini, Cesare M. Terracciano
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cultured adult cardiac tissue undergoes rapid dedifferentiation, which hinders chronic in vitro studies. Here the authors investigate biomimetic electromechanical stimulation of adult myocardial slices applying different preload conditions, identifyi
Externí odkaz:
https://doaj.org/article/3121859689094ac79bf739761e7891fe
Autor:
Brian X. Wang, Laura Nicastro, Liam Couch, Worrapong Kit-Anan, Barrett Downing, Kenneth T. MacLeod, Cesare M. Terracciano
Publikováno v:
Cells, Vol 11, Iss 7, p 1171 (2022)
Cardiac fibroblasts regulate the development of the adult cardiomyocyte phenotype and cardiac remodeling in disease. We investigate the role that cardiac fibroblasts-secreted extracellular vesicles (EVs) have in the modulation of cardiomyocyte Ca2+ c
Externí odkaz:
https://doaj.org/article/31937fd2fba040a6b252d09d12125a8a
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The adult human heart has an exceptional ability to alter its phenotype to adapt to changes in environmental demand. This response involves metabolic, mechanical, electrical, and structural alterations, and is known as cardiac plasticity. Understandi
Externí odkaz:
https://doaj.org/article/1254438e1343409daa6835fbeb2e9322
Autor:
Rasheda A. Chowdhury, Konstantinos N. Tzortzis, Emmanuel Dupont, Shaun Selvadurai, Filippo Perbellini, Chris D. Cantwell, Fu Siong Ng, Andre R. Simon, Cesare M. Terracciano, Nicholas S. Peters
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract The contact cardiac electrogram is derived from the extracellular manifestation of cellular action potentials and cell-to-cell communication. It is used to guide catheter based clinical procedures. Theoretically, the contact electrogram and
Externí odkaz:
https://doaj.org/article/f3def2e7326c4f699b77217db0871ad1
Autor:
Filippo Perbellini, Alan K. L. Liu, Samuel A. Watson, Ifigeneia Bardi, Stephen M. Rothery, Cesare M. Terracciano
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Several pathologic conditions of the heart lead to cardiac structural remodelling. Given the high density and the opaque nature of the myocardium, deep three dimensional (3D) imaging is difficult to achieve and structural analysis of patholo
Externí odkaz:
https://doaj.org/article/8d48eaeaeee24bf3b3d109a86746c56c