Výsledky vyhledávání - "Cesare F. Valenti"

fig.S2new from Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors

Autor: Claudia Chiodoni, Mario P. Colombo, Katia Scotlandi, Claudio Tripodo, Sabina Sangaletti, Barbara Cappetti, Mariella Parenza, Alessia Burocchi, Cesare F. Valenti, Lucia Bongiovanni, Maria Cristina Manara, Cecilia Garofalo, Ilaria Torselli, Silvia Galvan, Valeria Cancila, Laura Botti, Chiara Ratti

Figure S2 show additional H&E and IHC images and data on mOS14 cell line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b471e89efd7050be8a20081d00f74bd
https://doi.org/10.1158/1078-0432.22465770

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Data from Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors

Purpose: Osteosarcoma, the most common primary bone tumor, is characterized by an aggressive behavior with high tendency to develop lung metastases as well as by multiple genetic aberrations that have hindered the development of targeted therapies. N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d77576bac08aac2fe8607d271dcd48
https://doi.org/10.1158/1078-0432.c.6526149

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Fig.S4 from Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors

Figure S4 shows qPCR validation of data from Immune Panel card and in vitro analysis of chemokine expression upon trabectedin treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080d4c46b7db28fb05cbfac81d9fed6b
https://doi.org/10.1158/1078-0432.22465791.v1

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Table S2-S3-S4 from Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors

lists of differentially expressed genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ce4f81e3d5daa2dd7fab06ced9aef1
https://doi.org/10.1158/1078-0432.22465773.v1

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Table S1 from Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors

list of primers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86f496cfa892fe801bcfead24b3f83c
https://doi.org/10.1158/1078-0432.22465776

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SupplementarydataREV from Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors

supplemental Material and methods and supplementary figure legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829b4782fb6929f823c13f8c3dc13e7d
https://doi.org/10.1158/1078-0432.22465779.v1

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Fig.S1new from Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors

figure S1 shows in vitro and in vivo cell line characterization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a19769bf5301dc53d6effd3cfe2d0bf
https://doi.org/10.1158/1078-0432.22465794.v1

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Fig.S5 new from Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors

Figure S5 shows vulcano plots from immune panel results and qPCR validation of specific genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d1a4c619e19d1057f2c3e3c30bd53a
https://doi.org/10.1158/1078-0432.22465788

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Fig.s3new from Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors

Figure S3 shows H&E on intrabone lesions and matrix deposition quantification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad78bb90c85dc76bf9a69584ef8dec0c
https://doi.org/10.1158/1078-0432.22465782.v1

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