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Autor:
Elizabeth G. Reisman, Javier Botella, Cheng Huang, Ralf B. Schittenhelm, David A. Stroud, Cesare Granata, Owala S. Chandrasiri, Georg Ramm, Viola Oorschot, Nikeisha J. Caruana, David J. Bishop
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Analyses of mitochondrial adaptations in human skeletal muscle have mostly used whole-muscle samples, where results may be confounded by the presence of a mixture of type I and II muscle fibres. Using our adapted mass spectrometry-based prot
Externí odkaz:
https://doaj.org/article/be9674725b674affb4d1ee6ce2d81638
Publikováno v:
The Journal of physiologyReferences. 597(16)
This comment can be found as comments in the Supporting Information of Bishop, D.J., Botella, J. and Granata, C. (2019), Rebuttal from David J. Bishop, Javier Botella and Cesare Granata. J Physiol, 597: 4121-4122. at https://doi.org/10.1113/JP278329
Autor:
Bedair Dewidar, Lucia Mastrototaro, Cornelia Englisch, Claudia Ress, Cesare Granata, Elisabeth Rohbeck, Dominik Pesta, Geronimo Heilmann, Martin Wolkersdorfer, Irene Esposito, Michelle Reina Do Fundo, Fariba Zivehe, Aslihan Yavas, Michael Roden
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104714- (2023)
Summary: Background: Disturbed hepatic energy metabolism contributes to non-alcoholic fatty liver (NAFLD), but the development of changes over time and obesity- or diabetes-related mechanisms remained unclear. Methods: Two-day old male C57BL/6j mice
Externí odkaz:
https://doaj.org/article/2ea07f5ef7394e27b4129d4349050a24
Autor:
Claire Thomas, Rémi Delfour‐Peyrethon, Karen Lambert, Cesare Granata, Thomas Hobbs, Christine Hanon, David J. Bishop
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Purpose: The purpose of this study was to evaluate the effect of pre-exercise alkalosis, induced via ingestion of sodium bicarbonate, on changes to lactate/pH regulatory proteins and mitochondrial function induced by a sprint-interval exercise sessio
Externí odkaz:
https://doaj.org/article/5d010090b17c45558825e735670407ad
Autor:
Cesare Granata, Nikeisha J. Caruana, Javier Botella, Nicholas A. Jamnick, Kevin Huynh, Jujiao Kuang, Hans A. Janssen, Boris Reljic, Natalie A. Mellett, Adrienne Laskowski, Tegan L. Stait, Ann E. Frazier, Melinda T. Coughlan, Peter J. Meikle, David R. Thorburn, David A. Stroud, David J. Bishop
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Exercise training can be therapeutic but how mitochondria respond remains unclear. Here, the authors use multiple omics techniques to reveal a complex network of non-stoichiometric mitochondrial adaptations that are prioritized or deprioritised durin
Externí odkaz:
https://doaj.org/article/bea2037780444510914f0ea9d4120a6f
Autor:
Alex M. Parker, Mitchel Tate, Darnel Prakoso, Minh Deo, Andrew M. Willis, David M. Nash, Daniel G. Donner, Simon Crawford, Helen Kiriazis, Cesare Granata, Melinda T. Coughlan, Miles J. De Blasio, Rebecca H. Ritchie
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
People affected by diabetes are at an increased risk of developing heart failure than their non-diabetic counterparts, attributed in part to a distinct cardiac pathology termed diabetic cardiomyopathy. Mitochondrial dysfunction and excess reactive ox
Externí odkaz:
https://doaj.org/article/41a69cb22fe945b8a7151b8c5c3a1286
Autor:
Javier Botella, Nicholas A. Jamnick, Cesare Granata, Amanda J. Genders, Enrico Perri, Tamim Jabar, Andrew Garnham, Michael Lazarou, David J. Bishop
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2619 (2022)
Autophagy is a key intracellular mechanism by which cells degrade old or dysfunctional proteins and organelles. In skeletal muscle, evidence suggests that exercise increases autophagosome content and autophagy flux. However, the exercise-induced resp
Externí odkaz:
https://doaj.org/article/baeb6ea51bda436aaa307b61552ee48b
Autor:
Malcolm Eaton, Cesare Granata, Julianne Barry, Adeel Safdar, David Bishop, Jonathan P. Little
Publikováno v:
Journal of Sport and Health Science, Vol 7, Iss 2, Pp 191-196 (2018)
Background: Exercise promotes numerous phenotypic adaptations in skeletal muscle that contribute to improved function and metabolic capacity. An emerging body of evidence suggests that skeletal muscle also releases a myriad of factors during exercise
Externí odkaz:
https://doaj.org/article/0477b616b84049d0a0feb1c061bb8f0e
Autor:
Sih Min Tan, Runa S. J. Lindblom, Mark Ziemann, Adrienne Laskowski, Cesare Granata, Matthew Snelson, Vicki Thallas-Bonke, Assam El-Osta, Carlos D. Baeza-Garza, Stuart T. Caldwell, Richard C. Hartley, Thomas Krieg, Mark E. Cooper, Michael P. Murphy, Melinda T. Coughlan
Publikováno v:
Nutrients, Vol 13, Iss 5, p 1457 (2021)
Diabetic kidney disease (DKD) remains the number one cause of end-stage renal disease in the western world. In experimental diabetes, mitochondrial dysfunction in the kidney precedes the development of DKD. Reactive 1,2-dicarbonyl compounds, such as
Externí odkaz:
https://doaj.org/article/016295ed8bb84dc298223e3caac612e3