Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Cesar A Vargas-Garcia"'
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206700 (2018)
Clinical trials are necessary in order to develop treatments for diseases; however, they can often be costly, time consuming, and demanding to the patients. This paper summarizes several common methods used for optimal design that can be used to addr
Externí odkaz:
https://doaj.org/article/a6e1e383fb5643e882b812bc2c2455d6
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 8, p e1004972 (2016)
Inside individual cells, expression of genes is inherently stochastic and manifests as cell-to-cell variability or noise in protein copy numbers. Since proteins half-lives can be comparable to the cell-cycle length, randomness in cell-division times
Externí odkaz:
https://doaj.org/article/0fe6f40302814e96b6a4689de22be488
Publikováno v:
BMC Bioinformatics, Vol 20, Iss S23, Pp 1-6 (2019)
Abstract Background How small, fast-growing bacteria ensure tight cell-size distributions remains elusive. High-throughput measurement techniques have propelled efforts to build modeling tools that help to shed light on the relationships between cell
Externí odkaz:
https://doaj.org/article/e35ac9f98784427699b4104ca456d6da
Publikováno v:
2022 IEEE 61st Conference on Decision and Control (CDC).
Autor:
Niccolo Totis, Cesar Augusto Vargas-Garcia, Cesar Nieto, Abhyudai Singh, Armin Küper, Steffen Waldherr
Publikováno v:
IEEE Control Systems Letters. 5:725-730
The dynamics of the size distribution in growing and dividing rod-shaped bacteria can change depending on the perspective through which the cell population is observed. From the perspective of single-cell lineages, only one descendant is followed aft
Nonlinear feedback controllers are ubiquitous features of biological systems at different scales. A key motif arising in these systems is a sequestration-based feedback. As a physiological example of this type of feedback architecture, platelets (spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cad63d41fc26054248d57f7bf1e892c3
https://doi.org/10.1101/2022.03.26.485894
https://doi.org/10.1101/2022.03.26.485894
Publikováno v:
Physical Review E. 104
Bacterial division is an inherently stochastic process with effects on fluctuations of protein concentration and phenotype variability. Current modeling tools for the stochastic short-term cell-size dynamics are scarce and mainly phenomenological. He
Bacterial division is an inherently stochastic process. However, theoretical tools to simulate and study the stochastic transient dynamics of cell-size are scarce. Here, we present a general theoretical approach based on the Chapman-Kolmogorov formal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45c5a19a6e4c4a18b4b11e3866153b73
https://doi.org/10.1101/2020.09.29.319251
https://doi.org/10.1101/2020.09.29.319251
Recent studies describe bacterial division as a jump process triggered when it reaches a fixed number of stochastic discrete events at a rate depending on the cell-size. This theoretical approach enabled the computation of stochastic cell-size transi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05e12d273e2e2616dc4fa4efa07ed37f
https://doi.org/10.1101/2020.09.29.319152
https://doi.org/10.1101/2020.09.29.319152
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
How organisms maintain cell size homeostasis is a long-standing problem that remains unresolved, especially in multicellular organisms. Recent experiments in diverse animal cell types demonstrate that within a cell population, cellular proliferation