Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cerys S Manning"'
A dynamic, spatially periodic, micro‐pattern of HES5 underlies neurogenesis in the mouse spinal cord
Autor:
Veronica Biga, Joshua Hawley, Ximena Soto, Emma Johns, Daniel Han, Hayley Bennett, Antony D Adamson, Jochen Kursawe, Paul Glendinning, Cerys S Manning, Nancy Papalopulu
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 5, Pp n/a-n/a (2021)
Abstract Ultradian oscillations of HES Transcription Factors (TFs) at the single‐cell level enable cell state transitions. However, the tissue‐level organisation of HES5 dynamics in neurogenesis is unknown. Here, we analyse the expression of HES5
Externí odkaz:
https://doaj.org/article/203da099031b458daca8f28d58f4a6c0
Autor:
Nick E Phillips, Cerys S Manning, Tom Pettini, Veronica Biga, Elli Marinopoulou, Peter Stanley, James Boyd, James Bagnall, Pawel Paszek, David G Spiller, Michael RH White, Marc Goodfellow, Tobias Galla, Magnus Rattray, Nancy Papalopulu
Publikováno v:
eLife, Vol 5 (2016)
Recent studies suggest that cells make stochastic choices with respect to differentiation or division. However, the molecular mechanism underlying such stochasticity is unknown. We previously proposed that the timing of vertebrate neuronal differenti
Externí odkaz:
https://doaj.org/article/abe0521a88b64a059ce015c962daaea4
Autor:
Cerys S. Manning, Veronica Biga, James Boyd, Jochen Kursawe, Bodvar Ymisson, David G. Spiller, Christopher M. Sanderson, Tobias Galla, Magnus Rattray, Nancy Papalopulu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
The single-cell gene expression changes during spinal cord formation and neurogenesis in mice are unclear. Here, the authors use a HES5 reporter to live image, then mathematically model, oscillations in single cells in presumed progenitors and neuron
Externí odkaz:
https://doaj.org/article/625df354e8904d6d8d48ca404cd12312
Publikováno v:
Burton, J, Manning, C S, Rattray, M, Papalopulu, N & Kursawe, J 2021, ' Inferring kinetic parameters of oscillatory gene regulation from single cell time-series data ', Journal of the Royal Society Interface, vol. 18, no. 182 . https://doi.org/10.1098/rsif.2021.0393
Journal of the Royal Society Interface
Journal of the Royal Society Interface
This work was supported by a Wellcome Trust Four-Year PhD Studentship in Basic Science to J.B. (219992/Z/19/Z) and a Wellcome Trust Senior Research Fellowship to N.P. (090868/Z/09/Z). C.M. was supported by a Sir Henry Wellcome Fellowship (103986/Z/14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744b8ff246637071789d1dee74310b56
https://doi.org/10.1098/rsif.2021.0393
https://doi.org/10.1098/rsif.2021.0393
Autor:
Graeme C.M. Black, David M. McGaughey, Vinod Kumar Sharma, Eva Lenassi, Jamie M Ellingford, David J. Green, Panagiotis I. Sergouniotis, Cerys S Manning
Publikováno v:
Green, D, Lenassi, E, Manning, C, McGaughey, D, Sharma, V, Black, G, Ellingford, J & Sergouniotis, P 2021, ' North Carolina macular dystrophy: phenotypic variability and computational analysis of disease-associated non-coding variants ', Investigative Ophthalmology and Visual Science., vol. 62, no. 7, pp. 16 . https://doi.org/10.1167/iovs.62.7.16
Investigative Ophthalmology & Visual Science
Investigative Ophthalmology & Visual Science
Purpose North Carolina macular dystrophy (NCMD) is an autosomal dominant, congenital disorder affecting the central retina. Here, we report clinical and genetic findings in three families segregating NCMD and use epigenomic datasets from human tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54dab8ec41f28b054fe88c24b8e6790
https://research.manchester.ac.uk/en/publications/acbfede1-271d-4c44-984f-463a9fae8f1d
https://research.manchester.ac.uk/en/publications/acbfede1-271d-4c44-984f-463a9fae8f1d
Gene expression dynamics, such as stochastic oscillations and aperiodic fluctuations, have been associated with cell fate changes in multiple contexts, including development and cancer. Single cell live imaging of protein expression with endogenous r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e90a27f6e5ea558bcec417fe1dbee80
https://doi.org/10.1101/2021.05.12.443895
https://doi.org/10.1101/2021.05.12.443895
Autor:
Vinod Kumar Sharma, David J. Green, Jamie M Ellingford, Graeme C.M. Black, Cerys S Manning, Eva Lenassi, David M. McGaughey, Panagiotis I. Sergouniotis
PurposeNorth Carolina macular dystrophy (NCMD) is an autosomal dominant, congenital disorder affecting the central retina. Here, we report clinical and genetic findings in three families segregating NCMD and use epigenomic datasets from human tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::023d96daedd5838265efc5db8785e337
https://doi.org/10.1101/2021.03.05.21252975
https://doi.org/10.1101/2021.03.05.21252975
A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord
Autor:
Jochen Kursawe, Nancy Papalopulu, Joshua Hawley, Daniel Han, Hayley J. Bennett, Emma Johns, Ximena Soto, Cerys S Manning, Paul Glendinning, Antony Adamson, Veronica Biga
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 5, Pp n/a-n/a (2021)
Molecular Systems Biology
Molecular Systems Biology
Ultradian oscillations of HES Transcription Factors (TFs) at the single‐cell level enable cell state transitions. However, the tissue‐level organisation of HES5 dynamics in neurogenesis is unknown. Here, we analyse the expression of HES5 ex vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e670fd4e32206840d37c90a1b43f43
https://doi.org/10.1101/2020.08.03.234369
https://doi.org/10.1101/2020.08.03.234369
Autor:
Jochen Kursawe, Tobias Galla, Bodvar Ymisson, James Boyd, Nancy Papalopulu, Christopher M. Sanderson, David G. Spiller, Magnus Rattray, Cerys S Manning, Veronica Biga
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Manning, C, Biga, V, Boyd, J, Kursawe, J, Ymisson, B, Spiller, D, Sanderson, C M, Galla, T, Rattray, M & Papalopulu, A 2019, ' Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis ', Nature Communications, vol. 10, 2835 . https://doi.org/10.1038/s41467-019-10734-8
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Manning, C, Biga, V, Boyd, J, Kursawe, J, Ymisson, B, Spiller, D, Sanderson, C M, Galla, T, Rattray, M & Papalopulu, A 2019, ' Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis ', Nature Communications, vol. 10, 2835 . https://doi.org/10.1038/s41467-019-10734-8
During embryogenesis cells make fate decisions within complex tissue environments. The levels and dynamics of transcription factor expression regulate these decisions. Here, we use single cell live imaging of an endogenous HES5 reporter and absolute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f152eefb0d7d8af26ebdfcc8e6fbdc5b
http://europepmc.org/articles/PMC6597611
http://europepmc.org/articles/PMC6597611
Publikováno v:
Oncogene
The acquisition of cell motility is an early step in melanoma metastasis. Here we use intravital imaging of signalling reporter cell-lines combined with genome-wide transcriptional analysis to define signalling pathways and genes associated with mela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b140dc4a69a4e1f107145d8314c57b
https://doi.org/10.1038/onc.2014.362
https://doi.org/10.1038/onc.2014.362