Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Cerys Mayne"'
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Supplementary Table 4 from PI3K Pathway Activation Provides a Novel Therapeutic Target for Pediatric Ependymoma and Is an Independent Marker of Progression-Free Survival
Autor: Richard G. Grundy, Beth Coyle, John-Paul Kilday, Rebecca J. Chapman, Cerys Mayne, Hazel A. Rogers
PDF file - 31K, Summary of univariate survival statistics for factors analyzed, for an association with progression free survival, across the ependymoma cohort. A Kaplan Meier with a log rank test was used. Only factors with a p value less than 0.25
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5741196525da7dcac8c2740dba8a55ab
https://doi.org/10.1158/1078-0432.22448552
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2
Supplementary Table 2 from PI3K Pathway Activation Provides a Novel Therapeutic Target for Pediatric Ependymoma and Is an Independent Marker of Progression-Free Survival
Autor: Richard G. Grundy, Beth Coyle, John-Paul Kilday, Rebecca J. Chapman, Cerys Mayne, Hazel A. Rogers
PDF file - 35K, The table lists genes from the PI3K pathway displaying a significant difference in mRNA expression between tumors from different locations, identified using an ANOVA test. mRNA data originally published by Johnson et al. 2010 (Geo acc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a9f0f6202985e4fe39092447391926
https://doi.org/10.1158/1078-0432.22448558.v1
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3
Supplementary Table 1 from PI3K Pathway Activation Provides a Novel Therapeutic Target for Pediatric Ependymoma and Is an Independent Marker of Progression-Free Survival
Autor: Richard G. Grundy, Beth Coyle, John-Paul Kilday, Rebecca J. Chapman, Cerys Mayne, Hazel A. Rogers
PDF file - 1016K, The table lists genes displaying a significant difference in mRNA expression between tumors from different locations, identified using an ANOVA test. mRNA data originally published by Johnson et al. 2010 (Geo accession number GSE216
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b154b7288893b209784f34eb2003104
https://doi.org/10.1158/1078-0432.22448561.v1
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4
Supplementary Figure 1 from PI3K Pathway Activation Provides a Novel Therapeutic Target for Pediatric Ependymoma and Is an Independent Marker of Progression-Free Survival
Autor: Richard G. Grundy, Beth Coyle, John-Paul Kilday, Rebecca J. Chapman, Cerys Mayne, Hazel A. Rogers
PDF file - 163K, Survival analysis of P-AKT in tumors from patients in two clinical trial cohorts, CNS9204 and CNS9904,using the Kaplan Meier method with a log rank test. For the CNS9204 trial a significant association was found between P-AKT-N posit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b384aff1c54a5d8d10d7d7ce421cb1a
https://doi.org/10.1158/1078-0432.22448564
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5
Data from PI3K Pathway Activation Provides a Novel Therapeutic Target for Pediatric Ependymoma and Is an Independent Marker of Progression-Free Survival
Autor: Richard G. Grundy, Beth Coyle, John-Paul Kilday, Rebecca J. Chapman, Cerys Mayne, Hazel A. Rogers
Purpose: Currently, there are few effective adjuvant therapies for pediatric ependymoma outside confocal radiation, and prognosis remains poor. The phosphoinositide 3-kinase (PI3K) pathway is one of the most commonly activated pathways in cancer. PI3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d42d6c4ac3aa214b2f0a2ae7686fd52
https://doi.org/10.1158/1078-0432.c.6521426.v1
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6
PI3K Pathway Activation Provides a Novel Therapeutic Target for Pediatric Ependymoma and Is an Independent Marker of Progression-Free Survival
Autor: Cerys Mayne, Rebecca Chapman, Beth Coyle, Hazel A. Rogers, Richard Grundy, John-Paul Kilday
Publikováno v: Clinical Cancer Research. 19:6450-6460
Purpose: Currently, there are few effective adjuvant therapies for pediatric ependymoma outside confocal radiation, and prognosis remains poor. The phosphoinositide 3-kinase (PI3K) pathway is one of the most commonly activated pathways in cancer. PI3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc6a3dc35c955dbe7fe2ca11020fdad
https://doi.org/10.1158/1078-0432.ccr-13-0222
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8
Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death
Autor: John-Paul Kilday, Steven C. Clifford, Martyna Adamowicz-Brice, Jennifer H. Ward, Richard Grundy, Hazel A. Rogers, Beth Coyle, Edward C. Schwalbe, Cerys Mayne
Publikováno v: Acta Neuropathologica
Epigenetic alterations, including methylation, have been shown to be an important mechanism of gene silencing in cancer. Ependymoma has been well characterized at the DNA copy number and mRNA expression levels. However little is known about DNA methy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec543863238db0578640eaf0430bc93
http://europepmc.org/articles/PMC3316934
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9
PO44INVESTIGATION OF THE CLINICAL POTENTIAL OF AGENTS TARGETING EPIGENETIC MODIFICATIONS IN PAEDIATRIC EPENDYMOMA
Autor: Richard Grundy, Cerys Mayne, H. Kings, Rebecca Chapman, Hazel A. Rogers
INTRODUCTION: Alterations in epigenetic modifications are known to play a key role in many types of cancer. Agents targeting these modifications are in clinical development, with the most advanced targeting histone de-acetylation (HDACi) and DNA meth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5614f2194809c90e2ed99e16e8a385
https://europepmc.org/articles/PMC4657692/
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10
Systemic in vivo delivery of siRNA to tumours using combination of polyethyleneimine and transferrin-polyethyleneimine conjugates
Autor: Anna M, Grabowska, Ralf, Kircheis, Rajendra, Kumari, Philip, Clarke, Andrew, McKenzie, Jaime, Hughes, Cerys, Mayne, Arpan, Desai, Luana, Sasso, Susan A, Watson, Cameron, Alexander
Publikováno v: Biomaterials science. 3(11)
Materials for delivery of oligonucleotides need to be simple to produce yet effective in vivo to be considered for clinical applications. Formulations of biomaterials based on combinations of existing demonstrated polymeric gene carriers with targete
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36dddfc44e113ee25fba7b78bc2b3805
https://pubmed.ncbi.nlm.nih.gov/26351701
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