Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Cerys Docx"'
Autor:
Brian Cox, David C. Budd, Anna King, Gareth Williams, Nicholas Duggan, Rowan Stringer, Marcus Furegati, Alfred Schmidt, Josef G. Meingassner, Kamlesh Bala, Brian Everatt, Katharine L. Turner, Jennifer Simmons, Cerys Docx, Catherine Leblanc, Gerald Dubois, Frank Kalthoff, Caroline Wilson, Lucy Barker, Karen England, Nicola Arnold, John Westwick, Edward Charles Hall, Bindi Sohal, Jennifer Willis, Heinrich Aschauer, David Andrew Sandham, Rachael Profit, Zarin Brown, Lyndon Nigel Brown, Simon J. Watson, Jodie Manini, Christoph Walker, Matthew Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:6582-6591
Optimization of a 7-azaindole-3-acetic acid CRTh2 receptor antagonist chemotype derived from high throughput screening furnished a highly selective compound NVP-QAV680 with low nM functional potency for inhibition of CRTh2 driven human eosinophil and
Autor:
Karen England, Christoph Walker, Nicholas Duggan, Nicholas W. Morrell, Farheen Raza, Sarah Beach, Cerys Docx, Rachel J. Davies, Matthew Thomas, Catherine Leblanc, David C. Budd, Alexi Crosby, Clemence Lebret, Alan M. Holmes, Francis Schindler
Publikováno v:
The American journal of pathology. 174(2)
Mutations in the gene for the transforming growth factor (TGF)-beta superfamily receptor, bone morphogenetic protein receptor II, underlie heritable forms of pulmonary arterial hypertension (PAH). Aberrant signaling via TGF-beta receptor I/activin re
Autor:
John A. Marwick, Debra Hynx, Delwood L. Richardson, Probir Chakravarty, Paul Kirkham, Ruth Webster, Irfan Rahman, Christopher S. Stevenson, Cliff Battram, Christine Charman, June Giddings, Philip R. Cooper, Paul A. Whittaker, N. R. Nirmala, Cerys Docx, K D Butler
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 293(5)
Chronic obstructive pulmonary disease (COPD) is a smoking-related disease that lacks effective therapies due partly to the poor understanding of disease pathogenesis. The aim of this study was to identify molecular pathways that could be responsible