Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization.

Autor: Leung WH; bluebird bio, inc., Cambridge, Massachusetts, USA., Gay J; bluebird bio, inc., Cambridge, Massachusetts, USA., Martin U; bluebird bio, inc., Cambridge, Massachusetts, USA., Garrett TE; bluebird bio, inc., Cambridge, Massachusetts, USA., Horton HM; bluebird bio, inc., Cambridge, Massachusetts, USA., Certo MT; bluebird bio, inc., Cambridge, Massachusetts, USA., Blazar BR; Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA., Morgan RA; bluebird bio, inc., Cambridge, Massachusetts, USA., Gregory PD; bluebird bio, inc., Cambridge, Massachusetts, USA., Jarjour J; bluebird bio, inc., Cambridge, Massachusetts, USA., Astrakhan A; bluebird bio, inc., Cambridge, Massachusetts, USA.

Publikováno v: JCI insight [JCI Insight] 2019 Apr 30; Vol. 5. Date of Electronic Publication: 2019 Apr 30.

megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.

Autor: Boissel S; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA, Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101, USA, Pregenen, Inc., Seattle, WA 98103, USA, Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA, Cellectis S.A., Paris, 75013, France, Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA 98109, USA, Department of Biochemistry, University of Washington, Seattle, WA 98195, USA, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA and Department of Immunology, University of Washington, Seattle, WA 98195, USA., Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D, Scharenberg AM

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2014 Feb; Vol. 42 (4), pp. 2591-601. Date of Electronic Publication: 2013 Nov 26.

Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks.

Autor: Kuhar R; Center of Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, 98101 Washington, USA, Program in Molecular and Cellular Biology, University of Washington, Seattle, 98195 Washington, USA, Department of Immunology, University of Washington, Seattle, 98195 Washington, USA and Department of Biochemistry, University of Washington, Seattle, 98195 Washington, USA., Gwiazda KS, Humbert O, Mandt T, Pangallo J, Brault M, Khan I, Maizels N, Rawlings DJ, Scharenberg AM, Certo MT

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2014 Jan; Vol. 42 (1), pp. e4. Date of Electronic Publication: 2013 Oct 10.

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects.

Autor: Ramirez CL; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA., Certo MT, Mussolino C, Goodwin MJ, Cradick TJ, McCaffrey AP, Cathomen T, Scharenberg AM, Joung JK

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2012 Jul; Vol. 40 (12), pp. 5560-8. Date of Electronic Publication: 2012 Feb 28.

Tracking genome engineering outcome at individual DNA breakpoints.

Autor: Certo MT; Program in Molecular and Cellular Biology, University of Washington, Seattle, Washington, USA., Ryu BY, Annis JE, Garibov M, Jarjour J, Rawlings DJ, Scharenberg AM

Publikováno v: Nature methods [Nat Methods] 2011 Jul 10; Vol. 8 (8), pp. 671-6. Date of Electronic Publication: 2011 Jul 10.