Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer.

Autor: Chibaya L; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Lusi CF; Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA USA., DeMarco KD; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Kane GI; Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA USA., Brassil ML; Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA USA., Parikh CN; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Murphy KC; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Li J; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Naylor TE; Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA USA., Cerrutti J; Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA USA., Peura J; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Pitarresi JR; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Zhu LJ; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Fitzgerald KA; Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Atukorale PU; Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA USA.; Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Cancer Center, University of Massachusetts Chan Medical School, Worcester, MA. USA., Ruscetti M; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Cancer Center, University of Massachusetts Chan Medical School, Worcester, MA. USA.; Immunology and Microbiology Program, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 18. Date of Electronic Publication: 2023 Sep 18.