Výsledky vyhledávání - "Ceritinib, genotoxic impurities"

A simple and sensitive LC-MS/MS method for determination and quantification of potential genotoxic impurities in ceritinib active pharmaceutical ingredient

Autor: Nives Galić, Mislav Runje, Mia Antolčić

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was used for quantification of four potential genotoxic impurities (PGIs) in the ceritinib active pharmaceutical ingredient. Chromatographic separation was achieved using a YMC-Triart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56eb0a204e74d4c5d10f5e8a9cb423e
https://www.bib.irb.hr/1067010

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Development and validation of UPLC‐MS/MS method for the determination of genotoxic impurities in Ceritinib active pharmaceutical ingredient

Autor: Antolčić, Mia, Runje, Mislav, Galić, Nives, Jurković, Vedrana

Potential genotoxic impurities (PGIs) are impurities that have a structural alert related to genotoxicity, whereas genotoxic impurities (GTIs) are PGIs that were proved to be genotoxic during toxicological assessment [1]. Both pharmaceutical industri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::20f10e1b592b080f50cb5c798e90a290
https://www.bib.irb.hr/998210

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