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pro vyhledávání: '"Ceri Wiggins"'
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells
Autor:
Anna Dickson, Niamh Mullooly, Alessia Serrano, Leire Escudero-Ibarz, Ceri Wiggins, Davide Gianni
Publikováno v:
SLAS Discovery, Vol 28, Iss 2, Pp 29-35 (2023)
Small airway epithelial cells (SAECs) play a central role in the pathogenesis of lung diseases and are now becoming a crucial cellular model for target identification and validation in drug discovery. However, primary cell lines such as SAECs are oft
Externí odkaz:
https://doaj.org/article/90774f826a334bbfa2cc682dcb20356b
Publikováno v:
Cancer Research. 73:4289-4289
Advances in the development of clinically effective therapeutic strategies for targeting KRAS mutant tumors have been hampered by the lack of suitable in vitro tools and the inability to correlate findings from current in vitro KRAS dependency models