Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Ceri E. Oldreive"'
Autor:
Ceri E. Oldreive, Anna Skowronska, Nicholas J. Davies, Helen Parry, Angelo Agathanggelou, Sergey Krysov, Graham Packham, Zbigniew Rudzki, Laura Cronin, Katerina Vrzalikova, Paul Murray, Elena Odintsova, Guy Pratt, A. Malcolm R. Taylor, Paul Moss, Tatjana Stankovic
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 11, Pp 1401-1412 (2015)
Chronic lymphocytic leukaemia (CLL) cells require microenvironmental support for their proliferation. This can be recapitulated in highly immunocompromised hosts in the presence of T cells and other supporting cells. Current primary CLL xenograft mod
Externí odkaz:
https://doaj.org/article/375d1d3350404f2199c867a0890e9f1f
Autor:
Angelo Agathanggelou, Victoria J. Weston, Tracey Perry, Nicholas J. Davies, Anna Skowronska, Daniel T. Payne, John S. Fossey, Ceri E. Oldreive, Wenbin Wei, Guy Pratt, Helen Parry, David Oscier, Steve J. Coles, Paul S. Hole, Richard L. Darley, Michael McMahon, John D. Hayes, Paul Moss, Grant S. Stewart, A. Malcolm R. Taylor, Tatjana Stankovic
Publikováno v:
Haematologica, Vol 100, Iss 8 (2015)
Inactivation of the Ataxia Telangiectasia Mutated gene in chronic lymphocytic leukemia results in resistance to p53-dependent apoptosis and inferior responses to treatment with DNA damaging agents. Hence, p53-independent strategies are required to ta
Externí odkaz:
https://doaj.org/article/043481b5ed054be7b760c0b02db05858
Autor:
Christopher Fegan, Christopher I. Jones, Eve Coulter, Chris Pepper, Emma Halliwell, Emma Kennedy, Barnaby Clark, Stephen Devereux, Angelo Agathanggelou, Timothy Chevassut, Thomas A Burley, Rosalynd Johnston, Tatjana Stankovic, Elisabeth Jane Walsby, Ceri E. Oldreive, Triantafillos Liloglou, Elizabeth H Phillips, Andrea Pepper, Nick Davies, Martina Seiffert, Ralph Schulz, Simon Mitchell, Nuria Profitos-Peleja
Publikováno v:
Phillips, E 2021, ' TLR9 expression in Chronic Lymphocytic Leukemia identifies a pro-migratory subpopulation and novel therapeutic target. ', Blood, vol. 137, no. 22, pp. 3064-3078 . https://doi.org/10.1182/blood.2020005964
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Chronic lymphocytic leukemia (CLL) remains incurable despite B-cell receptor–targeted inhibitors revolutionizing treatment. This suggests that other signaling molecules are involved in disease escape mechanisms and resistance. Toll-like receptor 9
Autor:
Dragana Janic, Ceri E. Oldreive, Edward Smith, Philip J. Byrd, Tatjana Stankovic, Alexander J Taylor, Grant S. Stewart, Anna Skowronska, Lidija Dokmanovic, Nicholas J. Davies, Malcolm Taylor, Shankara Paneesha, Marwan Kwok, Sana Farhat, Guy Pratt, Paul Moss, Samuel Clokie, Manoj Raghavan
Publikováno v:
Leukemia & Lymphoma. 60:1823-1826
Partner and localizer of BRCA2 (PALB2), is a principal component of Homologous Recombination Repair (HRR) facilitating recruitment of HRR proteins such as BRCA1, BRCA2 and Rad51. Inherited inactiva...
Autor:
Shankara Paneesha, Francesco Forconi, Helen Parry, Surita Dalal, Jingwen Mao, Peter Hillmen, Nicholas J. Davies, Duncan M. Baird, Paul Evans, Angelo Agathanggelou, Talha Munir, Tatjana Stankovic, A. Malcolm R. Taylor, Anshita Goel, Rhiannon E. Jones, Andrew D Beggs, Jean-Baptiste Cazier, Marwan Kwok, Archana Sharma-Oates, Naheema S. Gordon, Paul Moreton, Grigorios Papatzikas, Samantha Drennan, Andy C. Rawstron, Robert Hollows, Paul Moss, Edward Smith, Guy Pratt, Mayumi Hamada, Ceri E. Oldreive
Publikováno v:
Blood. 135(6)
Spontaneous regression is a recognized phenomenon in chronic lymphocytic leukemia (CLL) but its biological basis remains unknown. We undertook a detailed investigation of the biological and clinical features of 20 spontaneous CLL regression cases inc
Autor:
Peter Hillmen, Alan Lau, Helen Parry, Jeffrey L. Brown, Marwan Kwok, Nicholas J. Davies, Angelo Agathanggelou, Edward Smith, Malcolm Taylor, Guy Pratt, Eva Petermann, Tatjana Stankovic, Paul Moss, Grant S. Stewart, Ceri E. Oldreive
Publikováno v:
Blood. 127:582-595
TP53 and ataxia telangiectasia mutated (ATM) defects are associated with genomic instability, clonal evolution, and chemoresistance in chronic lymphocytic leukemia (CLL). Currently, therapies capable of providing durable remissions in relapsed/refrac
Autor:
Guy Pratt, Daniel Slade, Simon Rule, David Oscier, Michael J. Griffiths, Ceri E. Oldreive, Rebecca Bishop, George A Follows, Paul Moss, Martin J. S. Dyer, Adrian Bloor, Stephen Devereux, Andrew R. Pettitt, Christina Yap, Peter Hillmen, David Allsup, Christopher Fegan, Estella Matutes, Tatjana Stankovic
Publikováno v:
BRITISH JOURNAL OF HAEMATOLOGY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c6d51aba914d13b3c6b351e097a92f
Autor:
Tracey Perry, Elliot J. Yates, Guy Pratt, Céline Reverdy, Sina Yadollahi, Pamela Kearns, Peter Hillmen, Tatjana Stankovic, Remi Delansorne, A. Malcolm R. Taylor, Paul Moss, Jingwen Mao, Anastasia Zlatanou, David Da Costa, Ceri E. Oldreive, Marwan Kwok, Nicholas J. Davies, Angelo Agathanggelou, Anna Skowronska, Helen Parry, Edward Smith, Shankara Paneesha, Grant S. Stewart
Publikováno v:
Blood. 130(2)
The role of deubiquitylase ubiquitin-specific protease 7 (USP7) in the regulation of the p53-dependent DNA damage response (DDR) pathway is well established. Whereas previous studies have mostly focused on the mechanisms underlying how USP7 directly
Autor:
Peter Thomas, Martin J. S. Dyer, A. Malcolm R. Taylor, Ceri E. Oldreive, Anna Skowronska, David Gonzalez, Estella Matutes, Tatjana Stankovic, Gulshanara Ahmed, Zadie Davis, David Oscier, Paul Moss, Anton Parker, Sue Richards
Publikováno v:
Journal of Clinical Oncology. 30:4524-4532
Purpose The prognostic significance of ATM mutations in chronic lymphocytic leukemia (CLL) is unclear. We assessed their impact in the context of a prospective randomized trial. Patients and Methods We analyzed the ATM gene in 224 patients treated on
Autor:
Anna Skowronska, Zbigniew Rudzki, Guy Pratt, Graeme C. M. Smith, Martin J. S. Dyer, Pamela Kearns, Victoria J Weston, A. Malcolm R. Taylor, Ceri E. Oldreive, Paul Moss, Tatjana Stankovic, J. E. Powell, David Oscier
Publikováno v:
Blood. 116:4578-4587
The Ataxia Telangiectasia Mutated (ATM) gene is frequently inactivated in lymphoid malignancies such as chronic lymphocytic leukemia (CLL), T-prolymphocytic leukemia (T-PLL), and mantle cell lymphoma (MCL) and is associated with defective apoptosis i