Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ceren H Çitirikkaya"'
Autor:
Aristeidis Lentzas, Mark C. de Gooijer, Stefanie Zuidema, Amber Meurs, Ceren H. Çitirikkaya, Nikkie Venekamp, Jos H. Beijnen, Olaf van Tellingen
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Pharmacotherapy for brain diseases is severely compromised by the blood-brain barrier (BBB). ABCB1 and ABCG2 are drug transporters that restrict drug entry into the brain and their inhibition can be used as a strategy to boost dru
Externí odkaz:
https://doaj.org/article/57eb6677d2ba47b88093983f8eec384d
Autor:
Rebeca, Uceda-Castro, Andreia S, Margarido, Lesley, Cornet, Serena, Vegna, Kerstin, Hahn, Ji-Ying, Song, Diana A, Putavet, Mariska, van Geldorp, Ceren H, Çitirikkaya, Peter L J, de Keizer, Leon C, Ter Beek, Gerben R, Borst, Leila, Akkari, Olaf, van Tellingen, Marike L D, Broekman, Claire, Vennin, Jacco, van Rheenen
Publikováno v:
Cell Reports Medicine. 3:100821
An increasing number of breast cancer patients develop brain metastases (BM). Standard-of-care treatments are largely inefficient, and breast cancer brain metastasis (BCBM) patients are considered untreatable. Immunotherapies are not successfully emp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8217ebde6a1b86fc7ee8118f1a0abe16
https://doi.org/10.1016/j.xcrm.2022.100821
https://doi.org/10.1016/j.xcrm.2022.100821
Autor:
Paul L G Slangen, Ceren H Çitirikkaya, Ronak Shah, Hilal Çolakoğlu, Gerben R. Borst, Mark C. de Gooijer, Amal El Ouazani, Olaf van Tellingen
Publikováno v:
Neuro Oncol
Their location and highly aggressive nature renders glioblastoma (GBM) among the most deadly and devastating of human malignancies. Despite extensive treatment involving surgery and adjuvant chemo-radiotherapy, the prognosis is still dismal and novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018dc52c6fe304b2d58a576d895d9de2
https://europepmc.org/articles/PMC7651030/
https://europepmc.org/articles/PMC7651030/
Autor:
Ceren H Çitirikkaya, Stefanie Zuidema, Olaf van Tellingen, Nikkie Venekamp, Mark C. de Gooijer, Amber Meurs, Jos H. Beijnen
Publikováno v:
Neuro Oncol
The blood-brain barrier (BBB) is a formidable hurdle to successful pharmacotherapy of intracranial diseases. ABCB1 and ABCG2 are efflux transporters that play an important role in the BBB, keeping substances out of the brain. Elacridar and tariquidar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef562a587dbf56cf8613d201090bb9a8
https://europepmc.org/articles/PMC7651375/
https://europepmc.org/articles/PMC7651375/
Autor:
Gerben R. Borst, Olaf van Tellingen, Ceren H Çitirikkaya, Amal El Ouazani, Paul L G Slangen, Ronak Shah, Hilal Çolakoğlu, Mark C. de Gooijer
Publikováno v:
Clinical Cancer Research. 27:PO-003
Radiotherapy remains one of the most effective modalities for anticancer treatment. Boosting the efficacy of radiotherapy is therefore a logical avenue to improve patient survival. We have developed a radiosensitization strategy called ‘induction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4b4ce3862c4e59b58f0bed20d780604
https://doi.org/10.1158/1557-3265.radsci21-po-003
https://doi.org/10.1158/1557-3265.radsci21-po-003
Autor:
Olaf van Tellingen, Tessa Buckle, E. Marleen Kemper, Ceren H Çitirikkaya, Mark C. de Gooijer, Jos H. Beijnen, Levi C.M. Buil
Publikováno v:
Cell Reports Medicine, 2(1):100184. Cell Press
Cell Reports Medicine
Cell Reports Medicine, 2(1). ELSEVIER
Cell Reports Medicine
Cell Reports Medicine, 2(1). ELSEVIER
Summary The impact of a compromised blood-brain barrier (BBB) on the drug treatment of intracranial tumors remains controversial. We characterize the BBB integrity in several intracranial tumor models using magnetic resonance imaging, fluorescent dye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32cf3437f376309b90764a399fc7712
https://doi.org/10.1016/j.xcrm.2020.100184
https://doi.org/10.1016/j.xcrm.2020.100184
Autor:
Mark C. de Gooijer, Tessa Buckle, Olaf van Tellingen, Levi C.M. Buil, E. Marleen Kemper, Ceren H Çitirikkaya, Jos H. Beijnen
Publikováno v:
Neuro Oncol
The impact of the blood-brain barrier (BBB) in brain tumors on the efficacy of anticancer drug therapy is controversial. In primary as well as metastatic brain tumors, the BBB is often disrupted. Yet, many intracranial cancers respond poorly to syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309fce8a4b92e0cc769cc070cf8f8ac4
https://doi.org/10.1093/neuonc/noaa215.277
https://doi.org/10.1093/neuonc/noaa215.277
Autor:
Levi C.M. Buil, N. de Vries, Ceren H Çitirikkaya, E. M. Kemper, M.C. de Gooijer, J. H. Beijnen, Lin Fan, O. van Tellingen
BACKGROUND: ABCB1 (P-glycoprotein; Pgp) and ABCG2 (Breast Cancer Resistance Protein; BCRP) are drug efflux transporters that are abundantly expressed at the blood-brain barrier (BBB). They limit the brain penetration of numerous compounds including m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dac242e3bcfa7f53b6cc53dfd22056e
https://europepmc.org/articles/PMC6144727/
https://europepmc.org/articles/PMC6144727/
Autor:
Ceren H Çitirikkaya, Olaf van Tellingen, Mark C. de Gooijer, Ping Zhang, Nishita Thota, Levi C.M. Buil, Jos H. Beijnen
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports, 8(1). NLM (Medline)
Scientific Reports
Scientific Reports, 8(1). NLM (Medline)
Scientific Reports
Characterization of the genomic landscapes of intracranial tumours has revealed a clear role for the PI3K-AKT-mTOR pathway in tumorigenesis and tumour maintenance of these malignancies, making phosphatidylinositol 3-kinase (PI3K) inhibition a promisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a79f1b2aa919dfc9c6b1f2354aae95
https://dspace.library.uu.nl/handle/1874/376139
https://dspace.library.uu.nl/handle/1874/376139