White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

Autor: Ozzoude, Miracle, Varriano, Brenda, Beaton, Derek, Ramirez, Joel, Adamo, Sabrina, Holmes, Melissa F, Scott, Christopher J M, Gao, Fuqiang, Sunderland, Kelly M, McLaughlin, Paula, Goubran, Maged, Kwan, Donna, Roberts, Angela, Bartha, Robert, Symons, Sean, Tan, Brian, Swartz, Richard H, Abrahao, Agessandro, Saposnik, Gustavo, Masellis, Mario, Lang, Anthony E, Marras, Connie, Zinman, Lorne, Shoesmith, Christen, Borrie, Michael, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Montero-Odasso, Manuel, Kumar, Sanjeev, Pasternak, Stephen, Strother, Stephen C, Pollock, Bruce G, Rajji, Tarek K, Seitz, Dallas, Tang-Wai, David F, Turnbull, John, Dowlatshahi, Dar, Hassan, Ayman, Casaubon, Leanne, Mandzia, Jennifer, Sahlas, Demetrios, Breen, David P, Grimes, David, Jog, Mandar, Steeves, Thomas D L, Arnott, Stephen R, Black, Sandra E, Finger, Elizabeth, Rabin, Jennifer, Tartaglia, Maria Carmela

Publikováno v: Ozzoude, M, Varriano, B, Beaton, D, Ramirez, J, Adamo, S, Holmes, M F, Scott, C J M, Gao, F, Sunderland, K M, McLaughlin, P, Goubran, M, Kwan, D, Roberts, A, Bartha, R, Symons, S, Tan, B, Swartz, R H, Abrahao, A, Saposnik, G, Masellis, M, Lang, A E, Marras, C, Zinman, L, Shoesmith, C, Borrie, M, Fischer, C E, Frank, A, Freedman, M, Montero-Odasso, M, Kumar, S, Pasternak, S, Strother, S C, Pollock, B G, Rajji, T K, Seitz, D, Tang-Wai, D F, Turnbull, J, Dowlatshahi, D, Hassan, A, Casaubon, L, Mandzia, J, Sahlas, D, Breen, D P, Grimes, D, Jog, M, Steeves, T D L, Arnott, S R, Black, S E, Finger, E & Rabin, J & Tartaglia, M C 2023, ' White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases ', Alzheimer's research & therapy, vol. 15, no. 1, pp. 114 . https://doi.org/10.1186/s13195-023-01257-y

BACKGROUND: Neuropsychiatric symptoms (NPS) are a core feature of most neurodegenerative and cerebrovascular diseases. White matter hyperintensities and brain atrophy have been implicated in NPS. We aimed to investigate the relative contribution of w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::6b60e6ab803354588c9121cee7259128
https://hdl.handle.net/20.500.11820/24fa1c84-ed2b-4e7b-bcd0-c07dd7adff84

Fabry Disease Caused by the GLA p.Phe113Leu (p.F113L) Variant: Natural History in Males

Autor: Cátia Carmona, Fernando Teixeira-e-Costa, Márcia Torres, Maria-Teresa Cardoso, José Pedro L. Nunes, Ana L. Soares, Marco Spada, Susana Sampaio, Odete Pereira, Dominique P. Germain, João Paulo Oliveira, Iulia E. Jurca-Simina, Albina Nowak, Susana Ferreira, Isabel Tavares, Frédéric Barbey, Fernanda Carvalho

Background, aims and methods: The α-galactosidase gene (GLA) c.337T>C/p.Phe113Leu variant was originally described in patients with late-onset cardiac forms of Fabry disease (FD), who had residual α-galactosidase activity. It has since emerged as t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a654e2c1a4828226b6fc2888125e19a4
https://hdl.handle.net/10400.17/4420

Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation

Autor: Sebastiaan Engelborghs, Steven Vermeulen, Mathieu Vandenbulcke, Arne De Roeck, Tobi Van den Bossche, Rik Vandenberghe, Marleen Van den Broeck, Anne Sieben, Jean-Jacques Martin, Annelies Laureys, Peter Paul De Deyn, Caroline Van Cauwenberghe, Patrick Cras, Kristel Sleegers, Maria Mattheijssens, Karin Peeters, Christine Van Broeckhoven, Elise Cuyvers

Publikováno v: Neurology
NEUROLOGY
Neurology, 86(23), 2126-2133. LIPPINCOTT WILLIAMS & WILKINS

OBJECTIVE: To generate a clinical and pathologic phenotype of patients carrying rare loss-of-function mutations in ABCA7, identified in a Belgian Alzheimer patient cohort and in an autosomal dominant family. METHODS: We performed a retrospective revi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0074b1ffad5f91ad6b53b698a1d61fac
https://hdl.handle.net/20.500.14017/b1e98cb3-6051-45a3-9e44-cfb2a8e069c0

Differential phenotypic and genetic expression of defence compounds in a plant–herbivore interaction along elevation

Autor: Anne-Lyse Ducrest, Tomasz Suchan, Nadir Alvarez, Sergio Rasmann, Loïc Pellissier, Ana L. Salgado

Publikováno v: Royal Society Open Science, Vol 3, Iss 9 (2016)
Royal Society Open Science, vol. 3, no. 9, pp. 160226
Royal Society Open Science

Elevation gradients impose large differences in abiotic and biotic conditions over short distances, in turn, likely driving differences in gene expression more than would genetic variation per se , as natural selection and drift are less likely to fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6a22c59aa5be3b8363e8bc6f189a69
https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.160226

Heart-Brain Interactions

Autor: Giuseppe Di Pasquale, Giuseppe Pinelli

In the last decade there has been a growing interest in the study of the interactions between the heart and the brain, especially in the field of cerebral ischemia. The interactions between cardiovascular and cerebrovascular diseases are of relevance