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An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae

Autor: Fasullo, Michael, Freedland, Julian, St John, Nick, Cera, Cinzia, Egner, Patricia, Hartog, Matt, Ding, Xinxin

P450 activity is required to metabolically activate many chemical carcinogens, rendering them highly genotoxic. CYP3A4 is the most abundantly expressed P450 enzyme in the liver, accounting for most drug metabolism and constituting 50% of all hepatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::758ca385101ddfce012ba78ec301eb66
https://europepmc.org/articles/PMC5479318/

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Genome Profiling for Aflatoxin B1 Resistance in Saccharomyces cerevisiae Reveals a Role for the CSM2/SHU Complex in Tolerance of Aflatoxin B1-Associated DNA Damage.

Autor: John, Nick St.¹, Freedland, Julian¹, Baldino, Henri¹, Doyle, Francis¹, Cera, Cinzia¹, Begley, Thomas², Fasullo, Michael¹ mfasullo@sunypoly.edu

Publikováno v: G3: Genes | Genomes | Genetics. Nov2020, Vol. 10 Issue 11, p3929-3947. 19p.

An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae.

Autor: Fasullo M; College of Nanoscale Sciences and Engineering, State University of New York Polytechnic Institute, Albany, New York.; Department of Biomedical Sciences, State University of New York at Albany, 150 New Scotland Avenue, Albany, New York., Freedland J; College of Nanoscale Sciences and Engineering, State University of New York Polytechnic Institute, Albany, New York., St John N; College of Nanoscale Sciences and Engineering, State University of New York Polytechnic Institute, Albany, New York., Cera C; College of Nanoscale Sciences and Engineering, State University of New York Polytechnic Institute, Albany, New York., Egner P; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland., Hartog M; College of Nanoscale Sciences and Engineering, State University of New York Polytechnic Institute, Albany, New York., Ding X; College of Nanoscale Sciences and Engineering, State University of New York Polytechnic Institute, Albany, New York.

Publikováno v: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2017 May; Vol. 58 (4), pp. 217-227. Date of Electronic Publication: 2017 Apr 24.