TonB-dependent receptor repertoire of Pseudomonas aeruginosa for uptake of siderophore-drug conjugates

Autor: Lena Mazza, Lucile Moynié, Alexandre Luscher, Dirk Bumann, Thilo Köhler, James H. Naismith, Pamela Saint Auguste, Daniel Pletzer

Publikováno v: 'Antimicrobial Agents and Chemotherapy ', vol: 62, pages: e00097-18-1-e00097-18-11 (2018)
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, Vol. 62, No 6 (2018) pp. e00097-18

The conjugation of siderophores to antimicrobial molecules is an attractive strategy to overcome the low outer membrane permeability of Gram-negative bacteria. In this Trojan horse approach, the transport of drug conjugates is redirected via TonB-dep

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