Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Cenzo Congiu"'
Autor:
Sandra Gouveia-Figueira, Jessica Karlsson, Alessandro Deplano, Sanaz Hashemian, Mona Svensson, Marcus Fredriksson Sundbom, Cenzo Congiu, Valentina Onnis, Christopher J Fowler
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139212 (2015)
Increased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a promising approach for pain-relief. One such compound with this profile is 2-(2-fluorobiphenyl-4-yl)-N-(3-
Externí odkaz:
https://doaj.org/article/a62dbb4ce5a34f169230d3bb37502d5d
Autor:
Jessica Karlsson, Carmine M Morgillo, Alessandro Deplano, Giovanni Smaldone, Emilia Pedone, F Javier Luque, Mona Svensson, Ettore Novellino, Cenzo Congiu, Valentina Onnis, Bruno Catalanotti, Christopher J Fowler
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142711 (2015)
Combined fatty acid amide hydrolase (FAAH) and cyclooxygenase (COX) inhibition is a promising approach for pain-relief. The Flu-AM1 and Ibu-AM5 derivatives of flurbiprofen and ibuprofen retain similar COX-inhibitory properties and are more potent inh
Externí odkaz:
https://doaj.org/article/7c0231800b9a4742aa904b05b0831370
Autor:
Wael Traboulsi, Aude Salomon, Valentina Onnis, Béatrice Desvergne, Cenzo Congiu, Mohamed Benharouga, Carine Winkler, Jean-Jacques Feige, Thierry Fournier, Sophie Brouillet, Qun-Yong Zhou, Pascale Hoffmann, Nadia Alfaidy, Vanessa Garnier
Publikováno v:
AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, 2015, 309 (4), pp.E357-E369. 〈10.1152/ajpendo.00093.2015〉
AJP-Endocrinology and Metabolism, 2015, 309 (4), pp.E357-E369. ⟨10.1152/ajpendo.00093.2015⟩
AJP-Endocrinology and Metabolism, American Physiological Society, 2015, 309 (4), pp.E357-E369. ⟨10.1152/ajpendo.00093.2015⟩
AJP-Endocrinology and Metabolism, American Physiological Society, 2015, 309 (4), pp.E357-E369. 〈10.1152/ajpendo.00093.2015〉
AJP-Endocrinology and Metabolism, 2015, 309 (4), pp.E357-E369. ⟨10.1152/ajpendo.00093.2015⟩
AJP-Endocrinology and Metabolism, American Physiological Society, 2015, 309 (4), pp.E357-E369. ⟨10.1152/ajpendo.00093.2015⟩
PPARγ-deficient mice die at E9.5 due to placental abnormalities. The mechanism by which this occurs is unknown. We demonstrated that the new endocrine factor EG-VEGF controls the same processes as those described for PPARγ, suggesting potential reg
Autor:
Daniela Maftei, Gianfranco Balboni, Severo Salvadori, Cenzo Congiu, Alessandro Deplano, Roberta Lattanzi, Lucia Negri, Valentina Onnis, Veronica Marconi
Publikováno v:
European Journal of Medicinal Chemistry. 81:334-340
A new efficient synthetic method to obtain prokineticin receptor antagonists based on the triazinedione scaffold is described. In this procedure the overall yield improves from 13% to about 54%, essentially for two factors: 1) N-(chlorocarbonyl) isoc
Autor:
Emmelie Björklund, Alan A. Wilson, Christopher J. Fowler, Cenzo Congiu, Valentina Onnis, Mariateresa Cipriano
Publikováno v:
European Journal of Pharmacology. 720:383-390
Inhibitors of the metabolism of the endogenous cannabinoid ligand anandamide by fatty acid amide hydrolase (FAAH) reduce the gastric damage produced by non-steroidal anti-inflammatory agents and synergise with them in experimental pain models. This m
Autor:
Valentina Onnis, Cenzo Congiu, Alessandro Deplano, Monica Demurtas, Mariateresa Cipriano, Christopher J. Fowler, MORGILLO, CARMINE MARCO, CATALANOTTI, BRUNO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::78a4cb15bcde076dc97d205f4ade6d4b
http://hdl.handle.net/11588/585780
http://hdl.handle.net/11588/585780
Autor:
David R. Bell, Cenzo Congiu, Michael S. Denison, Ian R. Mellor, Guochun He, Alwyn Fernandes, J. Craig Rowlands, Richard J. Wall, Valentina Onnis, Gianfranco Balboni, Martin Rose
Publikováno v:
University of Manchester-PURE
The Aryl hydrocarbon receptor (AhR) mediates the induction of a variety of xenobiotic metabolism genes. Activation of the AhR occurs through binding to a group of structurally diverse compounds, most notably dioxins, which are exogenous ligands. Isof
Autor:
Alessandro Deplano, Valentina Onnis, Mona Svensson, Christopher J. Fowler, Cenzo Congiu, Jessica Karlsson, Marcus Fredriksson Sundbom, Sandra Gouveia-Figueira, Sanaz Hashemian
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0139212 (2015)
PLoS ONE, Vol 10, Iss 9, p e0139212 (2015)
Background Increased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a promising approach for pain-relief. One such compound with this profile is 2-(2-fluorobiphenyl-
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:6238-6248
A series of 3,5-diaryl-4,5-dihydropyrazole regioisomers, and their 1-acetylated derivatives, bearing a 3,4,5-trimethoxyphenyl moiety combined with a variety of substituted phenyl rings, was synthesized and evaluated for antitumor activity. Results of
Autor:
Emma Söderström, Christopher J. Fowler, Cenzo Congiu, Valentina Onnis, Franziska Hempel, Emmelie Björklund
Publikováno v:
Journal of Medicinal Chemistry. 53:2286-2298
Fatty acid amide hydrolase (FAAH) is the key hydrolytic enzyme for the endogenous cannabinoid receptor ligand anandamide. The synthesis and evaluation for their FAAH inhibitory activities of a series of 18 paracetamol esters are described. Structure-