PLK4 as a potential target to enhance radiosensitivity in triple-negative breast cancer

Autor: Sierra Pellizzari, Vasudeva Bhat, Harjot Athwal, David W. Cescon, Alison L. Allan, Armen Parsyan

Publikováno v: Radiation Oncology, Vol 19, Iss 1, Pp 1-8 (2024)

Abstract Radioresistance is one of the barriers to developing more effective therapies against the most aggressive, triple-negative, breast cancer (TNBC) subtype. In our previous studies, we showed that inhibition of Polo-like Kinase 4 (PLK4) by a no

Externí odkaz: https://doaj.org/article/61c0db00737c4c9c86f1edbde2ca4845

Radiation-induced abnormal centrosome amplification and mitotic catastrophe in human cervical tumor HeLa cells and murine mammary tumor EMT6 cells

Autor: Masaki Fujimoto, Tomoki Bo, Tohru Yamamori, Hironobu Yasui, Osamu Inanami, Kumiko Yamamoto

Publikováno v: Journal of Clinical Biochemistry and Nutrition

Mitotic catastrophe is a form of cell death linked to aberrant mitosis caused by improper or uncoordinated mitotic progression. Abnormal centrosome amplification and mitotic catastrophe occur simultaneously, and some cells with amplified centrosomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abbd12d2f7bf27e0e30f52dc30a99d6
http://hdl.handle.net/2115/82881

A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition.

Autor: Li J; Department of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA., Urabe G; Department of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA., Huang Y; Department of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA., Zhang M; Department of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.; Cellular and Molecular Pathology Graduate Program, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA., Wang B; Department of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA., Marcho L; Davis Heart and Lung Research Institute, Wexner Medical Center, Ohio State University, Columbus, Ohio, USA., Shen H; Department of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA., Kent KC; Department of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA., Guo LW; Department of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.

Publikováno v: JACC. Basic to translational science [JACC Basic Transl Sci] 2021 Mar 22; Vol. 6 (3), pp. 257-283. Date of Electronic Publication: 2021 Mar 22 (Print Publication: 2021).