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Autor:
Nassar, ZD, Mah, CY, Dehairs, J, Burvenich, Ingrid, Irani, S, Centenera, MM, Helm, M, Shrestha, RK, Moldovan, M, Don, AS, Holst, J, Scott, Andrew, Horvath, LG, Lynn, DJ, Selth, LA, Hoy, AJ, Swinnen, JV, Butler, LM
Fatty acid b-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic efficacy of targeting FAO in clinical prostate tumors cultured ex vivo, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7747ebd564a13ebd0b1816ac70cb82b2
Autor:
Philip A. Gregory, Margaret M. Centenera, Lisa M. Butler, Brett G. Hollier, Rajdeep Das, Nataly Stylianou, Wayne D. Tilley, Scott L. Townley, Adrienne R. Hanson, Amina Zoubeidi, Gregory J. Goodall, Carolina Soekmadji, Katrina Sweeney, Colleen C. Nelson, Isabel Coutinho, Lidija Jovanovic, Luke A. Selth
Publikováno v:
Europe PubMed Central
MicroRNA-375 (miR-375) is frequently elevated in prostate tumors and cell-free fractions of patient blood, but its role in genesis and progression of prostate cancer is poorly understood. In this study, we demonstrated that miR-375 is inversely corre
Autor:
Rahman R; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia., Rahaman MH; Drug Discovery and Development, Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia., Hanson AR; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia., Choo N; Biomedicine Discovery Institute Cancer Program, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia., Xie J; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia., Townley SL; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia., Shrestha R; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia.; Flinders University, Freemasons Centre for Male Health and Wellbeing, Bedford Park, SA, Australia., Hassankhani R; Drug Discovery and Development, Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia., Islam S; Drug Discovery and Development, Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia., Ramm S; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia., Simpson KJ; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, VIC, Australia., Risbridger GP; Biomedicine Discovery Institute Cancer Program, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Cabrini Institute, Cabrini Health, Malvern, Melbourne, VIC, Australia.; Melbourne Urological Research Alliance (MURAL), Monash Biomedicine Discovery Institute Cancer Program, Monash University, Clayton, VIC, Australia., Best G; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia., Centenera MM; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.; Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia., Balk SP; Beth Israel Deaconess Medical Center, Boston, MA, USA., Kichenadasse G; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia.; Department of Medical Oncology, Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, SA, South Australia., Taylor RA; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Cabrini Institute, Cabrini Health, Malvern, Melbourne, VIC, Australia.; Melbourne Urological Research Alliance (MURAL), Monash Biomedicine Discovery Institute Cancer Program, Monash University, Clayton, VIC, Australia.; Biomedicine Discovery Institute Cancer Program, Department of Physiology, Monash University, Clayton, VIC, Australia., Butler LM; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.; Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia., Tilley WD; Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia., Conn SJ; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia., Lawrence MG; Biomedicine Discovery Institute Cancer Program, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Cabrini Institute, Cabrini Health, Malvern, Melbourne, VIC, Australia.; Melbourne Urological Research Alliance (MURAL), Monash Biomedicine Discovery Institute Cancer Program, Monash University, Clayton, VIC, Australia., Wang S; Drug Discovery and Development, Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia., Selth LA; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia. luke.selth@flinders.edu.au.; Flinders University, Freemasons Centre for Male Health and Wellbeing, Bedford Park, SA, Australia. luke.selth@flinders.edu.au.; Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia. luke.selth@flinders.edu.au.
Publikováno v:
British journal of cancer [Br J Cancer] 2024 Aug 08. Date of Electronic Publication: 2024 Aug 08.
Autor:
Lin HM; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; St Vincent's Clinical School, University of New South Wales, Darlinghurst, NSW, Australia., Yang X; Dana-Farber Cancer Institute, Boston, MA., Centenera MM; South Australian Immunogenomics Cancer Institute and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, SA, Australia.; South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Huynh K; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.; Department of Cardiovascular Research Translation and Implementation, La Trobe University, Bundoora, VIC, Australia., Giles C; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.; Department of Cardiovascular Research Translation and Implementation, La Trobe University, Bundoora, VIC, Australia., Dehairs J; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven, Leuven, Belgium., Swinnen JV; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven, Leuven, Belgium., Hoy AJ; School of Medical Sciences, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia., Meikle PJ; Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.; Department of Cardiovascular Research Translation and Implementation, La Trobe University, Bundoora, VIC, Australia., Butler LM; South Australian Immunogenomics Cancer Institute and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, SA, Australia.; South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Taplin ME; Dana-Farber Cancer Institute, Boston, MA., Horvath LG; Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; Chris O'Brien Lifehouse, Camperdown, NSW, Australia.; Royal Prince Alfred Hospital, Camperdown, NSW, Australia.; University of Sydney, Camperdown, NSW, Australia.
Publikováno v:
JCO precision oncology [JCO Precis Oncol] 2024 Jul; Vol. 8, pp. e2400260.
Autor:
Hinneh JA; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA, 5000, Australia.; Freemason's Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA, 5000, Australia.; Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.; Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia., Gillis JL; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA, 5000, Australia.; Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia., Mah CY; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA, 5000, Australia.; Freemason's Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA, 5000, Australia.; Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia., Irani S; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA, 5000, Australia.; Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia., Shrestha RK; Freemason's Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA, 5000, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia.; College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia.; Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, 5042, Australia., Ryan NK; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA, 5000, Australia.; Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia., Atsushi E; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Nassar ZD; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA, 5000, Australia.; Freemason's Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA, 5000, Australia.; Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia., Lynn DJ; Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.; College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia., Selth LA; Freemason's Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA, 5000, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia.; College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia.; Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, 5042, Australia., Kato M; Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Centenera MM; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA, 5000, Australia.; Freemason's Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA, 5000, Australia.; Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia., Butler LM; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA, 5000, Australia. lisa.butler@adelaide.edu.au.; Freemason's Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA, 5000, Australia. lisa.butler@adelaide.edu.au.; Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia. lisa.butler@adelaide.edu.au.; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia. lisa.butler@adelaide.edu.au.
Publikováno v:
British journal of cancer [Br J Cancer] 2023 Oct; Vol. 129 (8), pp. 1350-1361. Date of Electronic Publication: 2023 Sep 06.
Autor:
Shin SY; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.; Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Centenera MM; South Australian Immunogenomics Cancer Institute and Freemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide, SA, Australia.; South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Hodgson JT; South Australian Immunogenomics Cancer Institute and Freemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide, SA, Australia.; South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Nguyen EV; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.; Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Butler LM; South Australian Immunogenomics Cancer Institute and Freemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide, SA, Australia.; South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Daly RJ; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.; Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Nguyen LK; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.; Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Publikováno v:
Frontiers in molecular biosciences [Front Mol Biosci] 2023 Jan 19; Vol. 10, pp. 1094321. Date of Electronic Publication: 2023 Jan 19 (Print Publication: 2023).
Autor:
Hinneh JA; South Australian Immunogenomics Cancer Institute and Adelaide Medical School, Adelaide, SA, Australia.; Freemason's Centre for Male Health and Wellbeing, The University of Adelaide, Adelaide, SA, Australia.; Precision Cancer Medicine, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.; Nagoya University Graduate School of Medicine, Nagoya, Japan., Gillis JL; South Australian Immunogenomics Cancer Institute and Adelaide Medical School, Adelaide, SA, Australia.; Precision Cancer Medicine, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Moore NL; South Australian Immunogenomics Cancer Institute and Adelaide Medical School, Adelaide, SA, Australia.; Precision Cancer Medicine, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Butler LM; South Australian Immunogenomics Cancer Institute and Adelaide Medical School, Adelaide, SA, Australia.; Freemason's Centre for Male Health and Wellbeing, The University of Adelaide, Adelaide, SA, Australia.; Precision Cancer Medicine, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Centenera MM; South Australian Immunogenomics Cancer Institute and Adelaide Medical School, Adelaide, SA, Australia.; Freemason's Centre for Male Health and Wellbeing, The University of Adelaide, Adelaide, SA, Australia.; Precision Cancer Medicine, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Publikováno v:
Frontiers in oncology [Front Oncol] 2022 Aug 10; Vol. 12, pp. 982231. Date of Electronic Publication: 2022 Aug 10 (Print Publication: 2022).
Harnessing the Heterogeneity of Prostate Cancer for Target Discovery Using Patient-Derived Explants.
Autor:
Centenera MM; Adelaide Medical School, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia.; Freemasons Centre for Male Health and Wellbeing, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA 5000, Australia., Vincent AD; Adelaide Medical School, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia.; Freemasons Centre for Male Health and Wellbeing, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia., Moldovan M; Biometry Hub, Faculty of Science, University of Adelaide, Waite Campus, SA 5005, Australia., Lin HM; Garvan Institute for Medical Research, Darlinghurst, NSW 2010, Australia., Lynn DJ; Precision Medicine Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA 5000, Australia.; Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia., Horvath LG; Garvan Institute for Medical Research, Darlinghurst, NSW 2010, Australia.; Chris O'Brien Lifehouse, Camperdown, NSW 2050, Australia.; University of Sydney, Camperdown, NSW 2006, Australia., Butler LM; Adelaide Medical School, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia.; Freemasons Centre for Male Health and Wellbeing, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA 5000, Australia.
Publikováno v:
Cancers [Cancers (Basel)] 2022 Mar 28; Vol. 14 (7). Date of Electronic Publication: 2022 Mar 28.
Autor:
Butler LM; Adelaide Medical School and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, Australia. lisa.butler@adelaide.edu.au.; South Australian Health and Medical Research Institute, Adelaide, Australia., Mah CY; Adelaide Medical School and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Machiels J; Laboratory of Lipid Metabolism and Cancer, LKI - Leuven Cancer Institute, KU Leuven, Leuven, Belgium., Vincent AD; Adelaide Medical School and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Irani S; Adelaide Medical School and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Mutuku SM; Adelaide Medical School and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Spotbeen X; South Australian Health and Medical Research Institute, Adelaide, Australia.; Laboratory of Lipid Metabolism and Cancer, LKI - Leuven Cancer Institute, KU Leuven, Leuven, Belgium., Bagadi M; Laboratory of Lipid Metabolism and Cancer, LKI - Leuven Cancer Institute, KU Leuven, Leuven, Belgium., Waltregny D; Department of Urology, University Hospital of Liège, Liege, Belgium., Moldovan M; South Australian Health and Medical Research Institute, Adelaide, Australia., Dehairs J; Laboratory of Lipid Metabolism and Cancer, LKI - Leuven Cancer Institute, KU Leuven, Leuven, Belgium., Vanderhoydonc F; Laboratory of Lipid Metabolism and Cancer, LKI - Leuven Cancer Institute, KU Leuven, Leuven, Belgium., Bloch K; Laboratory of Lipid Metabolism and Cancer, LKI - Leuven Cancer Institute, KU Leuven, Leuven, Belgium., Das R; Adelaide Medical School and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, Australia.; Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide, Adelaide, Australia.; Northwestern University, Feinberg School of Medicine, Comprehensive Transplant Center, Chicago, Illinois., Stahl J; Clinpath Laboratories, Adelaide, Australia., Kench JG; Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, NSW Health Pathology, Camperdown, New South Wales, Australia.; Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.; University of Sydney, Camperdown, New South Wales, Australia., Gevaert T; Department of Urology, UZ Leuven, Leuven, Belgium., Derua R; Department of Cellular and Molecular Medicine and SyBioMa Center, KU Leuven, Leuven, Belgium., Waelkens E; Department of Cellular and Molecular Medicine and SyBioMa Center, KU Leuven, Leuven, Belgium., Nassar ZD; Adelaide Medical School and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Selth LA; Adelaide Medical School and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, Australia.; Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide, Adelaide, Australia.; Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia., Trim PJ; South Australian Health and Medical Research Institute, Adelaide, Australia., Snel MF; South Australian Health and Medical Research Institute, Adelaide, Australia., Lynn DJ; South Australian Health and Medical Research Institute, Adelaide, Australia.; Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia., Tilley WD; Adelaide Medical School and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, Australia.; Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide, Adelaide, Australia., Horvath LG; Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.; University of Sydney, Camperdown, New South Wales, Australia.; Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia.; University of New South Wales, Sydney, New South Wales, Australia., Centenera MM; Adelaide Medical School and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Swinnen JV; Laboratory of Lipid Metabolism and Cancer, LKI - Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
Publikováno v:
Cancer research [Cancer Res] 2021 Oct 01; Vol. 81 (19), pp. 4981-4993. Date of Electronic Publication: 2021 Aug 06.