Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Cenglin Xu"'
Autor:
Li Cheng, Ling Xiao, Wenkai Lin, Minzhu Li, Jiaying Liu, Xiaoyun Qiu, Menghan Li, Yanrong Zheng, Cenglin Xu, Yi Wang, Zhong Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Fear memory is essential for survival and adaptation, yet excessive fear memories can lead to emotional disabilities and mental disorders. Despite previous researches have indicated that histamine H1 receptor (H1R) exerts critical and intric
Externí odkaz:
https://doaj.org/article/76c984a637c64278812a7f1eb5399eb5
Autor:
Yu-Jun Wang, Gui-Ying Zan, Cenglin Xu, Xue-Ping Li, Xuelian Shu, Song-Yu Yao, Xiao-Shan Xu, Xiaoyun Qiu, Yexiang Chen, Kai Jin, Qi-Xin Zhou, Jia-Yu Ye, Yi Wang, Lin Xu, Zhong Chen, Jing-Gen Liu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Ample evidence has suggested the stress etiology of depression, but the underlying mechanism is not fully understood yet. Here, we report that chronic social defeat stress (CSDS) attenuates the excitatory output of the claustrum (CLA) to the
Externí odkaz:
https://doaj.org/article/1b785317c072493d8496ce17573abaa2
Autor:
Mengdi Zhang, Lin Yang, Zhongxia Li, Fan Fei, Yuan Zhou, Dongxiao Jiang, Yuyi Zheng, Hui Cheng, Yu Wang, Cenglin Xu, Jiajia Fang, Shuang Wang, Zhong Chen, Yi Wang
Publikováno v:
Neurobiology of Disease, Vol 192, Iss , Pp 106424- (2024)
Background: Managing refractory epilepsy presents a significant a substantial clinical challenge. Deep brain stimulation (DBS) has emerged as a promising avenue for addressing refractory epilepsy. However, the optimal stimulation targets and effectiv
Externí odkaz:
https://doaj.org/article/d92215605d99473ab329028009bc15e7
Autor:
Hongyi Ye, Lingqi Ye, Lingli Hu, Yuyu Yang, Yi Ge, Ruotong Chen, Shan Wang, Bo Jin, Wenjie Ming, Zhongjin Wang, Sha Xu, Cenglin Xu, Yi Wang, Yao Ding, Junming Zhu, Meiping Ding, Zhong Chen, Shuang Wang, Cong Chen
Publikováno v:
Neurobiology of Disease, Vol 191, Iss , Pp 106409- (2024)
Interictal epileptiform discharges (IEDs) often co-occur across spatially-separated cortical regions, forming IED networks. However, the factors prompting IED propagation remain unelucidated. We hypothesized that slow oscillations (SOs) might facilit
Externí odkaz:
https://doaj.org/article/c5c6d9ef89634be6b55099d5ae17c8b3
Autor:
Liying Chen, Yingwei Xu, Heming Cheng, Zhongxia Li, Nanxi Lai, Menghan Li, Yeping Ruan, Yang Zheng, Fan Fei, Cenglin Xu, Jiao Ma, Shuang Wang, Yan Gu, Feng Han, Zhong Chen, Yi Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-16 (2023)
Abstract Temporal lobe epilepsy (TLE), one common type of medically refractory epilepsy, is accompanied with altered adult-born dentate granule cells (abDGCs). However, the causal role of abDGCs in recurrent seizures of TLE is not fully understood. H
Externí odkaz:
https://doaj.org/article/7a4f5a41d79a461097d368005b81d20b
Autor:
Yang Zheng, Cenglin Xu, Jinyi Sun, Wenjie Ming, Sijie Dai, Yuying Shao, Xiaoyun Qiu, Menghan Li, Chunhong Shen, Jinghong Xu, Fan Fei, Jiajia Fang, Xuhong Jiang, Guoqing Zheng, Weiwei Hu, Yi Wang, Shuang Wang, Meiping Ding, Zhong Chen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery, likely due to the widespread seizure network. Previous studies have primarily focused on the disruption of dysplastic lesions, rathe
Externí odkaz:
https://doaj.org/article/66e6549eed4f4bafac9c0a794a4aa3f7
Autor:
Heming Cheng, Qiuwen Lou, Nanxi Lai, Liying Chen, Shuo Zhang, Fan Fei, Chenshu Gao, Shuangshuang Wu, Feng Han, Jinggen Liu, Yi Guo, Zhong Chen, Cenglin Xu, Yi Wang
Publikováno v:
Neurobiology of Disease, Vol 189, Iss , Pp 106358- (2023)
The raphe nuclei, the primary resource of forebrain 5-HT, play an important but heterogeneous role in regulating subcortical excitabilities. Fundamental circuit organizations of different median raphe (MR) subsystems are far from completely understoo
Externí odkaz:
https://doaj.org/article/4877bd5ccf05484fb2db8664a8fdb2b3
Autor:
Junli Zhao, Jinyi Sun, Yang Zheng, Yanrong Zheng, Yuying Shao, Yulan Li, Fan Fei, Cenglin Xu, Xiuxiu Liu, Shuang Wang, Yeping Ruan, Jinggen Liu, Shumin Duan, Zhong Chen, Yi Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Neocortical epilepsy is resistant to current treatments. Zhao et al. report that optogenetic stimulation of astrocytes effectively attenuates seizures via driving Na+-K+-ATPase, indicating a potential treatment strategy for intractable epilepsy.
Externí odkaz:
https://doaj.org/article/30ddf29e53094c5492c8778fde427748
Autor:
Fan Fei, Xia Wang, Cenglin Xu, Jiaying Shi, Yiwei Gong, Heming Cheng, Nanxi Lai, Yeping Ruan, Yao Ding, Shuang Wang, Zhong Chen, Yi Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The subiculum is known to contribute to seizures in epilepsy. Here the authors investigate the circuit mechanism by which the subiculum contributes to initiation and propagation of hippocampal seizures in a mouse model.
Externí odkaz:
https://doaj.org/article/ebeb5d1c67fc40d1b599f20a1bbb77af
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106049- (2023)
Epilepsy, one of the most common neurological disorders, often is not well controlled by current pharmacological and surgical treatments. Sensory neuromodulation, including multi-sensory stimulation, auditory stimulation, olfactory stimulation, is a
Externí odkaz:
https://doaj.org/article/f96cc94763dc4fedad9378ba3290492a