Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cenchen Zhan"'
Autor:
Meena V, Patel, Hillary M, Peltier, Mark A, Matulenko, John R, Koenig, Marc J, C Scanio, Rebecca J, Gum, Odile F, El-Kouhen, Meagan M, Fricano, Greta L, Lundgaard, Torben, Neelands, Xu-Feng, Zhang, Cenchen, Zhan, Madhavi, Pai, Nayereh, Ghoreishi-Haack, Thomas, Hudzik, Gary, Gintant, Ruth, Martin, Steve, McGaraughty, Jun, Xu, Daniel, Bow, John C, Kalvass, Philip R, Kym, David A, DeGoey, Michael E, Kort
Publikováno v:
Bioorganicmedicinal chemistry. 63
The voltage-gated sodium channel Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd1fb7249454a3a0f2ca17d9cb54dd42
https://pubmed.ncbi.nlm.nih.gov/35436748
https://pubmed.ncbi.nlm.nih.gov/35436748
Autor:
Meena V. Patel, Hillary M. Peltier, Mark A. Matulenko, John R. Koenig, Marc J. C. Scanio, Rebecca J. Gum, Odile F. El-Kouhen, Meagan M. Fricano, Greta L. Lundgaard, Torben Neelands, Xu-Feng Zhang, Cenchen Zhan, Madhavi Pai, Nayereh Ghoreishi-Haack, Thomas Hudzik, Gary Gintant, Ruth Martin, Steve McGaraughty, Jun Xu, Daniel Bow, John C. Kalvass, Philip R. Kym, David A. DeGoey, Michael E. Kort
Publikováno v:
Bioorganic & Medicinal Chemistry. 63:116743
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9360aff00f3964aaceb6096c8ef6bab3
https://doi.org/10.1016/j.bmc.2022.116743
https://doi.org/10.1016/j.bmc.2022.116743
Autor:
Lei Shi, Madhavi Pai, David A. Degoey, Jerome F. Daanen, Gin C. Hsieh, Cenchen Zhan, Nayereh S Ghoreishi-Haack, Meagan M. Fricano, Jennifer M. Frost, Kort Michael E, Greta L. Lundgaard, Mark A. Matulenko, Torben R. Neelands, Odile F. El-Kouhen, Xu-Feng Zhang, Rebecca J. Gum
Publikováno v:
Journal of Medicinal Chemistry. 59:3373-3391
The genetic validation for the role of the Nav1.7 voltage-gated ion channel in pain signaling pathways makes it an appealing target for the potential development of new pain drugs. The utility of nonselective Nav blockers is often limited due to adve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392a40f1e3a271f427919403b60ad5d8
https://doi.org/10.1021/acs.jmedchem.6b00063
https://doi.org/10.1021/acs.jmedchem.6b00063
Autor:
Jorge D. Brioni, Tracy L. Carr, Gin C. Hsieh, Madhavi Pai, Lawrence A. Black, Tiffany Runyan Garrison, Cenchen Zhan, Marlon D. Cowart, Erica Gomez, Gilbert Diaz, Arlene M. Manelli, Marina I. Strakhova, Anthony Lee, Jill M. Wetter
Publikováno v:
European Journal of Pharmacology. 684:87-94
Histamine H(3) receptor antagonists have been widely reported to improve performance in preclinical models of cognition, but more recently efficacy in pain models has also been described. Here, A-960656 ((R)-2-(2-(3-(piperidin-1-yl)pyrrolidin-1-yl)be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54c0e87b77f27eefbbaad46501b1babe
https://doi.org/10.1016/j.ejphar.2012.03.048
https://doi.org/10.1016/j.ejphar.2012.03.048
Autor:
Torben R. Neelands, Andrew O. Stewart, Gricelda H. Simler, Chengmin Zhong, Andrew J. King, Chang Z. Zhu, George Doherty, Andrew M. Swensen, Ivan Milicic, Janel M. Boyce-Rustay, Cenchen Zhan, Patricia N. Banfor, Timothy A. Vortherms, Victoria E. Scott, Natalie Bratcher, Michael F. Jarvis, Wende Niforatos, Helmut Mack, Pramila Bhatia
Publikováno v:
Biochemical Pharmacology. 83:406-418
Blockade of voltage-gated Ca²⁺ channels on sensory nerves attenuates neurotransmitter release and membrane hyperexcitability associated with chronic pain states. Identification of small molecule Ca²⁺ channel blockers that produce significant an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0e7b78ced7c8136433729efa16945e
https://doi.org/10.1016/j.bcp.2011.10.019
https://doi.org/10.1016/j.bcp.2011.10.019
Autor:
Emily E. Cole, Chengmin Zhong, Timothy A. Vortherms, Ivan Milicic, Min Zhang, Chang Z. Zhu, Joseph P. Mikusa, Donna M. Gauvin, Chih-Hung Lee, Cenchen Zhan, Michael F. Jarvis, Katharine L. Chu, Robert S. Bitner, Madhavi Pai, La Geisha Lewis, Anton Bespalov, Anthony W. Bannon, Torben R. Neelands, Shailen K. Joshi, Searle Xenia B, Steve McGaraughty, Victoria E. Scott, Wende Niforatos, Jun Xu, Victoria A. Roderwald, Andrew M. Swensen
Publikováno v:
The journal of pain. 15(4)
Voltage-gated Ca 2+ channels play an important role in nociceptive transmission. There is significant evidence supporting a role for N-, T- and P/Q-type Ca 2+ channels in chronic pain. Here, we report that A-1264087, a structurally novel state-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5ebc35303dd87b3a62588855368676
https://pubmed.ncbi.nlm.nih.gov/24374196
https://pubmed.ncbi.nlm.nih.gov/24374196
Autor:
Marlon, Cowart, Gin, Hsieh, Lawrence A, Black, Cenchen, Zhan, Erica J, Gomez, Madhavi, Pai, Marina, Strakhova, Arlene, Manelli, Tracy, Carr, Jill, Wetter, Anthony, Lee, Gilbert, Diaz, Tiffany, Garrison, Jorge D, Brioni
Publikováno v:
European journal of pharmacology. 684(1-3)
Histamine H(3) receptor antagonists have been widely reported to improve performance in preclinical models of cognition, but more recently efficacy in pain models has also been described. Here, A-960656 ((R)-2-(2-(3-(piperidin-1-yl)pyrrolidin-1-yl)be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::764e1b80d58c593fcd9bbd7cfee9c6b9
https://pubmed.ncbi.nlm.nih.gov/22504024
https://pubmed.ncbi.nlm.nih.gov/22504024
Autor:
Gerald P. Donovan, Olga Varlamova, Donna M. Morrissey, Warren D. W. Heston, Kenneth G. Surowitz, William C. Olson, Paul J. Maddon, Cenchen Zhan, Robert R. Arrigale, Amy J. Chodera, Jason P. Gardner, Dangshe Ma, Norbert Schulke
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(22)
Prostate-specific membrane antigen (PSMA) is a type 2 integral membrane glycoprotein that serves as an attractive target for cancer immunotherapy by virtue of its abundant and restricted expression on the surface of prostate carcinomas and the neovas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33486c30130cbb20b57b13db119544f5
https://pubmed.ncbi.nlm.nih.gov/14583590
https://pubmed.ncbi.nlm.nih.gov/14583590
Autor:
Frost, Jennifer M., DeGoey, David A., Lei Shi, Gum, Rebecca J., Fricano, Meagan M., Lundgaard, Greta L., El-Kouhen, Odile F., Hsieh, Gin C., Neelands, Torben, Matulenko, Mark A., Daanen, Jerome F., Pai, Madhavi, Ghoreishi-Haack, Nayereh, Cenchen Zhan, Xu-Feng Zhang, Kort, Michael E.
Publikováno v:
Journal of Medicinal Chemistry; 4/14/2016, Vol. 59 Issue 7, p3373-3391, 19p