Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Cemsel Bafligil"'
Autor:
Xuemin Wang, Pik Fang Kho, Dhanya Ramachandran, Cemsel Bafligil, Frederic Amant, Ellen L. Goode, Rodney J. Scott, Ian Tomlinson, D. Gareth Evans, Emma J. Crosbie, Thilo Dörk, Amanda B. Spurdle, Dylan M. Glubb, Tracy A. O'Mara
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106590- (2023)
Summary: To detect novel endometrial cancer risk variants, we leveraged information from endometrial cancer risk factors in a multi-trait GWAS analysis. We first assessed causal relationships between established and suspected endometrial cancer risk
Externí odkaz:
https://doaj.org/article/8dd1483258de40008b74d4a653bb1ccc
Autor:
Manman Guo, Cemsel Bafligil, Thomas Tapmeier, Carol Hubbard, Sanjiv Manek, Catherine Shang, Fernando O. Martinez, Nicole Schmidt, Maik Obendorf, Holger Hess-Stumpp, Thomas M. Zollner, Stephen Kennedy, Christian M. Becker, Krina T. Zondervan, Adam P. Cribbs, Udo Oppermann
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Endometriosis is a gynaecological condition characterised by immune cell infiltration and distinct inflammatory signatures found in the peritoneal cavity. In this study, we aim to characterise the immune microenvironment in sample
Externí odkaz:
https://doaj.org/article/15f988e46be6442287146db61267c609
Autor:
Cemsel Bafligil, Deborah J. Thompson, Artitaya Lophatananon, Neil A.J. Ryan, Miriam J. Smith, Joe Dennis, Krisztina Mekli, Tracy A. O’Mara, D. Gareth Evans, Emma J. Crosbie
Publikováno v:
Genetics in Medicine. 24:1847-1856
Single-nucleotide variations (SNVs) (formerly single-nucleotide polymorphism [SNV]) influence genetic predisposition to endometrial cancer. We hypothesized that a polygenic risk score (PRS) comprising multiple SNVs may improve endometrial cancer risk
Autor:
Oliver J. Kennedy, Cemsel Bafligil, Tracy A. O’Mara, Xuemin Wang, D. Gareth Evans, Siddhartha Kar, Emma J. Crosbie
Publikováno v:
Kennedy, O J, Bafligil, C, O’mara, T A, Wang, X, Evans, D G, Kar, S & Crosbie, E J 2022, ' Child and adult adiposity and subtype-specific endometrial cancer risk: a multivariable Mendelian randomisation study ', International journal of obesity . https://doi.org/10.1038/s41366-022-01231-y
Kennedy, O J, Bafligil, C, O’Mara, T, Wang, X, Evans, D G, Kar, S & Crosbie, E J 2023, ' Child and adult adiposity and subtype-specific endometrial cancer risk : a multivariable Mendelian randomisation study ', International Journal of Obesity, vol. 47, no. 1, pp. 87–90 . https://doi.org/10.1038/s41366-022-01231-y
Kennedy, O J, Bafligil, C, O’Mara, T, Wang, X, Evans, D G, Kar, S & Crosbie, E J 2023, ' Child and adult adiposity and subtype-specific endometrial cancer risk : a multivariable Mendelian randomisation study ', International Journal of Obesity, vol. 47, no. 1, pp. 87–90 . https://doi.org/10.1038/s41366-022-01231-y
Increased adiposity is a known risk factor for endometrial cancer (EC). This study aimed to disentangle the separate causal roles of child and adult adiposity on EC risk in adults, including endometrioid and non-endometrioid histological subtypes usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8be32f2c9fc2656b5c9e4ae71a1c1e
https://research.manchester.ac.uk/en/publications/68d579a0-d7bc-4dbf-a4b7-d7b5e2faf28a
https://research.manchester.ac.uk/en/publications/68d579a0-d7bc-4dbf-a4b7-d7b5e2faf28a
Autor:
Johanna, Härtl, Julia, Hartberger, Silke, Wunderlich, Isabell, Cordts, Cemsel, Bafligil, Marc, Sturm, Dominik, Westphal, Tobias, Haack, Bernhard, Hemmer, Benno David, Ikenberg, Marcus, Deschauer
Publikováno v:
Journal of neurology.
Background Genetic variants are considered to have a crucial impact on the occurrence of ischemic stroke. In clinical routine, the diagnostic value of next-generation sequencing (NGS) in the medical clarification of acute juvenile stroke has not been
Autor:
Oliver J, Kennedy, Cemsel, Bafligil, Tracy A, O'Mara, Xuemin, Wang, D Gareth, Evans, Siddhartha, Kar, Emma J, Crosbie
Publikováno v:
International journal of obesity (2005).
Increased adiposity is a known risk factor for endometrial cancer (EC). This study aimed to disentangle the separate causal roles of child and adult adiposity on EC risk in adults, including endometrioid and non-endometrioid histological subtypes usi
Autor:
Stefanie Mesch, Christian M. Becker, Maik Obendorf, Jianghai Lin, Catherine Shang, Nilufer Rahmioglu, Muthuswamy Raveendran, Ronald A. Harris, Jeffrey Rogers, Oliver Fischer, Grant W. Montgomery, Graham Wells, Udo Oppermann, Heather A. Simmons, Bianca De Leo, Joseph W. Kemnitz, Nicholas G. Martin, Denise Brocklebank, Cemsel Bafligil, Thomas M. Zollner, Sanjiv Manek, Manman Guo, Krina T. Zondervan, Ernesto Lowy, Holger Hess-Stumpp, Jens Nagel, Fernando O. Martinez, Andrew P. Morris, Gerton Lunter, Susan A. Treloar, Alexis Laux-Biehlmann, Stephen Kennedy, Thomas T. Tapmeier, Jessica Malzahn
Publikováno v:
Science Translational Medicine. 13
Endometriosis is a common chronic inflammatory condition causing pelvic pain and infertility in women, with limited treatment options and 50% heritability. We leveraged genetic analyses in two species with spontaneous endometriosis, humans and the rh
Autor:
Rodney J. Scott, Amanda B. Spurdle, Cemsel Bafligil, Ian Tomlinson, Thilo Dörk, Frédéric Amant, Dhanya Ramachandran, Tracy A. O'Mara, D. Gareth Evans, Dylan M. Glubb, Emma J Crosbie, Xuemin Wang, Pik Fang Kho, Ellen L. Goode
We have performed genetic correlation and Mendelian randomization analyses using publicly available genome-wide association study (GWAS) data to identify endometrial cancer risk factors. These and previously established risk factors of endometrial ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea865a10d75ac4d82341385d8ca7201a
https://doi.org/10.1101/2021.08.01.21261455
https://doi.org/10.1101/2021.08.01.21261455
Akademický článek
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Autor:
Neil A J Ryan, Anie Naqvi, D. Gareth Evans, Miriam J. Smith, Artitaya Lophatananon, Deborah J. Thompson, Cemsel Bafligil, Emma J Crosbie
Publikováno v:
Bafligil, C, Thompson, D J, Lophatananon, A, Smith, M J, Ryan, N A, Naqvi, A, Evans, D G & Crosbie, E J 2020, ' Association between genetic polymorphisms and endometrial cancer risk : a systematic review ', Journal of Medical Genetics, vol. 57, no. 9, pp. 591-600 . https://doi.org/10.1136/jmedgenet-2019-106529
Funder: national institute of health research
INTRODUCTION: Endometrial cancer is one of the most commonly diagnosed cancers in women. Although there is a hereditary component to endometrial cancer, most cases are thought to be sporadic and life
INTRODUCTION: Endometrial cancer is one of the most commonly diagnosed cancers in women. Although there is a hereditary component to endometrial cancer, most cases are thought to be sporadic and life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee15bcd69b901ec9862311789699c611
https://hdl.handle.net/1983/faaa9e93-3941-414e-be4d-47375c96fd36
https://hdl.handle.net/1983/faaa9e93-3941-414e-be4d-47375c96fd36