Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Cem Z, Görgün"'
Autor:
Presila Bejo, Eric B. Rimm, Nurdan Dagtekin, Eric Vaillancourt, Gurol Tuncman, Gökhan S. Hotamisligil, M. Furkan Burak, Cem Z. Görgün, Lydia Liu
Publikováno v:
Journal of the Endocrine Society
Asthma is a chronic inflammatory disease of the airways with an increasing prevalence but limited treatment options. Although the pathogenesis is not fully understood, it has a major immunometabolic component including contribution of lipid mediators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93af9ad5cf3816898a534f263fa2a94e
https://doi.org/10.1210/js.2019-or01-1
https://doi.org/10.1210/js.2019-or01-1
Autor:
Daping Fan, Robert P. Runner, Vladimir R. Babaev, Cem Z. Görgün, Huan Tao, Youmin Zhang, MacRae F. Linton, Gökhan S. Hotamisligil, Ebru Erbay, Sergio Fazio, Lei Ding
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Objective— The adipocyte/macrophage fatty acid-binding proteins aP2 (FABP4) and Mal1 (FABP5) are intracellular lipid chaperones that modulate systemic glucose metabolism, insulin sensitivity, and atherosclerosis. Combined deficiency of aP2 and Mal1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0bdfc1ee1a543418e821422482fc663
https://doi.org/10.1161/atvbaha.111.225839
https://doi.org/10.1161/atvbaha.111.225839
Autor:
Frank B. Hu, Ronald M. Evans, Lu Qi, Russell R. Nofsinger, Cem Z. Görgün, Sihao Liu, Chih-Hao Lee, Shannon M. Reilly, Prerna Bhargava, Matthew R. Gangl
Publikováno v:
Cell Metabolism. 12:643-653
SummaryThe transcriptional corepressor SMRT utilizes two major receptor-interacting domains (RID1 and RID2) to mediate nuclear receptor (NR) signaling through epigenetic modification. The physiological significance of such interaction remains unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ffaccdef9bc837231638e58c780ca8
https://doi.org/10.1016/j.cmet.2010.11.007
https://doi.org/10.1016/j.cmet.2010.11.007
Autor:
Nahum Sonenberg, Haiming Cao, Gurol Tuncman, Cem Z. Görgün, Takahisa Nakamura, Ping Li, Masato Furuhashi, Gökhan S. Hotamisligil
Publikováno v:
Cell. 140(3):338-348
SUMMARY As chronic inflammation is a hallmark of obesity, pathways that integrate nutrient- and pathogen sensing pathways are of great interest in understanding the mechanisms of insulin resistance, type 2 diabetes, and other chronic metabolic pathol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0a323c91d0b5c66dd17c471c55d9dc
Autor:
Joseph M. Reynolds, Katherine C. Brittingham, Gökhan S. Hotamisligil, Jill Suttles, Qiaohong Liu, Michael Gruenthal, Robert D. Stout, Yawei Liu, Cem Z. Görgün
Publikováno v:
The Journal of Immunology. 179:313-321
Fatty acid-binding proteins (FABPs) act as intracellular receptors for a variety of hydrophobic compounds, enabling their diffusion within the cytoplasmic compartment. Recent studies have demonstrated the ability of FABPs to simultaneously regulate m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656a1766897d5057ec6bf785984e533a
https://doi.org/10.4049/jimmunol.179.1.313
https://doi.org/10.4049/jimmunol.179.1.313
Autor:
Kathryn E. Wellen, Margaret F. Gregor, Raquel Fucho, Cem Z. Görgün, Masato Furuhashi, Eric Vaillancourt, Gökhan S. Hotamisligil, Fahri Saatcioglu, Carlos Morgan, Torstein Lindstad
Publikováno v:
Cell. 129:537-548
SummaryMetabolic and inflammatory pathways crosstalk at many levels, and, while required for homeostasis, interaction between these pathways can also lead to metabolic dysregulation under conditions of chronic stress. Thus, we hypothesized that mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6e0de1052846bef7b02420ffb5c1cd
https://doi.org/10.1016/j.cell.2007.02.049
https://doi.org/10.1016/j.cell.2007.02.049
Autor:
Gregory R. Steinberg, Mark A. Febbraio, David Carling, Sofianos Andrikopoulos, Bruce E. Kemp, Andrew L. Carey, Cem Z. Görgün, Gökhan S. Hotamisligil, Barbara C Fam, Joseph Proietto, Belinda J. Michell, Matthew J. Watt, Thomas W.H. Kay, Bryce J. W. van Denderen
Publikováno v:
Cell Metabolism. 4(6):465-474
Elevated levels of tumor necrosis factor (TNFalpha) are implicated in the development of insulin resistance, but the mechanisms mediating these chronic effects are not completely understood. We demonstrate that TNFalpha signaling through TNF receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c296bb14ebd34d47ec774bc836c55b
Autor:
Charles R. Mackay, Melinda J Frost, Cem Z. Görgün, Bennett O.V. Shum, Rakesh K. Kumar, G S Hotamisligil, Michael S. Rolph
Publikováno v:
Journal of Clinical Investigation. 116:2183-2192
The adipocyte fatty acid–binding protein aP2 regulates systemic glucose and lipid metabolism. We report that aP2, in addition to being abundantly expressed by adipocytes, is also expressed by human airway epithelial cells and shows a striking upreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9d759fa5b32e879ec5d84ddb6aa463
https://doi.org/10.1172/jci24767
https://doi.org/10.1172/jci24767
Autor:
Gurol Tuncman, Qiong Cao, Umut Ozcan, Laurie H. Glimcher, Ann-Hwee Lee, Cem Z. Görgün, Gökhan S. Hotamisligil, Neal N. Iwakoshi, Erkan Yilmaz, Esra Özdelen
Publikováno v:
Science. 306:457-461
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show that obesity causes endoplasmic reticulum (ER) stress. This stress in turn leads to suppressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2db8c1bc06610ce62994a440d73932
https://doi.org/10.1126/science.1103160
https://doi.org/10.1126/science.1103160
Autor:
Daniele Gandini, Chiara Chiellini, A Bertacca, Ennia Pardini, Cem Z. Görgün, Franco Folli, Roberto Dimitri, Lucia Perego, Luca Benzi, Antonio Giordano, Saverio Cinti, Gökhan S. Hotamisligil, Pietro Bottone, Silvia E. Novelli, Haiyan Xu, Renzo Navalesi, Alexander Soukas, P. Cecchetti, Mario Costa, Annamaria Ciccarone, Jeffrey M. Friedman, Margherita Maffei
Publikováno v:
Journal of Cellular Physiology. 190:251-258
Increase in adipose mass results in obesity and modulation of several factors in white adipose tissue (WAT). Two important examples are tumor necrosis factor alpha (TNFalpha) and leptin, both of which are upregulated in adipose tissue in obesity. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de1f2444e39d665de94a36ff66a217b2
https://doi.org/10.1002/jcp.10061
https://doi.org/10.1002/jcp.10061