Designing, synthesis and bioactivities of 4-[3-(4-hydroxyphenyl)-5-aryl-4,5-dihydro-pyrazol-1-yl]benzenesulfonamides

Autor: Halise Inci Gul, Ebru Mete, Sakip Emre Eren, Hiroshi Sakagami, Cem Yamali, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 169-175 (2017)

In this study, 4-[3-(4-hydroxyphenyl)-5-aryl-4,5-dihydro-pyrazol-1-yl]benzenesulfonamide (1–9) types compounds were synthesized and their chemical structures were confirmed by 1H NMR, 13C NMR and HRMS spectra. Cytotoxic and carbonic anhydrase (CA)

Externí odkaz: https://doaj.org/article/07b5424b884d4990987515c2a246034b

Recent Developments in Tacrine-based Hybrids as a Therapeutic Option for Alzheimer’s Disease

Autor: Cem Yamali, Seyda Donmez

Publikováno v: Mini-Reviews in Medicinal Chemistry. 23:869-880

Abstract: Alzheimer's disease (AD) is a multifactorial, irreversible, and age-related neurodegenerative disorder among the elderly. AD attracts attention due to its complex pathogenesis, morbidity and mortality rates, and the limitations of drugs use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020faac7a578581402dd827928fb99ab
https://doi.org/10.2174/1389557523666221201145141

Inhibitory effects of novel benzamide derivatives towards acetylcholinesterase enzyme

Autor: Cem YAMALI, Halise İnci GÜL, Serkan LEVENT, Yeliz DEMİR

Publikováno v: Volume: 8, Issue: 2 429-434
Journal of the Turkish Chemical Society Section A: Chemistry
Journal of the Turkish Chemical Society, Section A: Chemistry, Vol 8, Iss 2, Pp 429-434 (2021)

Alzheimer's disease is one of the diseases which is identified by progressive memory loss and cognitive deficits leading to a decline in the lifespan of the patients. The drugs used in the clinic show palliative properties and they are unable to modi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd31423dabd26e1a1691a70f3395ae9f
https://doi.org/10.18596/jotcsa.842465

Biological activities of a newly synthesized pyrazoline derivative 4-(3-(4-bromophenyl)-5-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide (B4) compound on rainbow trout alevins, Oncorhynchus mykiss

Autor: Gonca Alak, Cem Yamali, Arzu Uçar, Telat Yanik, Dilan Ozmen Ozgun, Rana Almuhur, Muhammed Atamanalp, Veysel Parlak, Halise Inci Gul, Mahmut Kocaman, Ahmed O. Maslat

Publikováno v: In Vitro Cellular & Developmental Biology - Animal. 57:17-20

[Abstract Not Available]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f44f1a64772b0f904d8753ed7d9a3d
https://doi.org/10.1007/s11626-020-00541-7

Phenothiazine‐based chalcones as potential dual‐target inhibitors toward cholinesterases (AChE, BuChE) and monoamine oxidases (MAO‐A, MAO‐B)

Autor: Feyza Sena Engin, Mehtap Tugrak, Yusuf Özkay, Cem Yamali, Halise Inci Gul, Serkan Levent, Sinan Bilginer, Begüm Nurpelin Sağlık, Dilan Ozmen Ozgun, Gulsen Ozli

Publikováno v: Journal of Heterocyclic Chemistry. 58:161-171

Chalcones targeting neurodegenerative diseases have been known as attractive structures in drug design and discovery. In this study, phenothiazine-based chalcones as ChEs and MAOs inhibitors were designed and synthesizedviabase-catalyzed Claisen-Schm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c62e84aa56b11df619011c767b054f8
https://doi.org/10.1002/jhet.4156