Zobrazeno 1 - 10
of 427
pro vyhledávání: '"Celso E. Gomez‐Sanchez"'
Autor:
Zhe Ye, Ryuji Okamoto, Hiromasa Ito, Rie Ito, Keishi Moriwaki, Mizuki Ichikawa, Lupiya Kimena, Yusuf Ali, Masaaki Ito, Celso E. Gomez‐Sanchez, Kaoru Dohi
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 5 (2024)
Background Myosin phosphatase targeting subunit 2 (MYPT2) is an important subunit of cardiac MLC (myosin light chain) phosphatase, which plays a crucial role in regulating the phosphorylation of MLC to phospho‐MLC (p‐MLC). A recent study demonstr
Externí odkaz:
https://doaj.org/article/cb95104932b8417e820612fdbbf17cdf
Autor:
Nae Takizawa, Susumu Tanaka, Koshiro Nishimoto, Yuki Sugiura, Makoto Suematsu, Chisato Ohe, Haruyuki Ohsugi, Yosuke Mizuno, Kuniaki Mukai, Tsugio Seki, Kenji Oki, Celso E. Gomez-Sanchez, Tadashi Matsuda
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 1, Pp 128-138 (2021)
Primary aldosteronism is most often caused by aldosterone-producing adenoma (APA) and bi-lateral adrenal hyperplasia. Most APAs are caused by somatic mutations of various ion channels and pumps, the most common being the inward-rectifying potassium c
Externí odkaz:
https://doaj.org/article/5a6de17491a143b8b902dfaecde28178
Autor:
Celso E. Gomez-Sanchez, Desmaré van Rooyen, William E. Rainey, Kazutaka Nanba, Amy R. Blinder, Radhakrishna Baliga
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Aldosterone-producing adenoma is a rare cause of hypertension in children. Only a limited number of cases of aldosterone-producing adenomas with somatic KCNJ5 gene mutations have been described in children. Blacks are particularly more susceptible to
Externí odkaz:
https://doaj.org/article/ab449a8b5c8f4c5d881794cc23a575eb
Autor:
Rami M. El Zein, Audrey H. Soria, Jose Felipe Golib Dzib, Amanda J. Rickard, Fabio L. Fernandes-Rosa, Benoit Samson-Couterie, Isabelle Giscos-Douriez, Angélique Rocha, Marko Poglitsch, Celso E. Gomez-Sanchez, Laurence Amar, Norbert B. Ghyselinck, Arndt Benecke, Maria-Christina Zennaro, Sheerazed Boulkroun
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-20 (2019)
Abstract Primary aldosteronism (PA) is the most frequent form of secondary arterial hypertension. Mutations in different genes increase aldosterone production in PA, but additional mechanisms may contribute to increased cell proliferation and aldoste
Externí odkaz:
https://doaj.org/article/3cff1a93869f4413b2da69cfd919de81
Autor:
J. Spencer Hauck, Zachary M. Howard, Jeovanna Lowe, Neha Rastogi, Madison G. Pico, Sarah A. Swager, Jennifer M. Petrosino, Celso E. Gomez-Sanchez, Elise P. Gomez-Sanchez, Federica Accornero, Jill A. Rafael-Fortney
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Acute skeletal muscle injury is followed by a temporal response of immune cells, fibroblasts, and muscle progenitor cells within the muscle microenvironment to restore function. These same cell types are repeatedly activated in muscular dystrophy fro
Externí odkaz:
https://doaj.org/article/12798ee57d8e4204a1997bf5cc71cfd1
Autor:
Sofia S. Pereira, Liliana Carvalho, Madalena M. Costa, Armindo Melo, Isabel M. P. L. V. O. Ferreira, Celso E. Gomez-Sanchez, Mariana P. Monteiro, Gavin Vinson, Duarte Pignatelli
Publikováno v:
Biomedicines, Vol 9, Iss 4, p 441 (2021)
Mineralocorticoid receptor antagonists (MRAs) are a class of anti-hypertensive drugs that act by blocking aldosterone action. The aim of this study was to evaluate whether the MRAs spironolactone and eplerenone influence adrenal cortical physiology a
Externí odkaz:
https://doaj.org/article/5787279bcf0944cdb61fe70e35fb0e83
Autor:
Coralie Drelon, Annabel Berthon, Isabelle Sahut-Barnola, Mickaël Mathieu, Typhanie Dumontet, Stéphanie Rodriguez, Marie Batisse-Lignier, Houda Tabbal, Igor Tauveron, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Celso E. Gomez-Sanchez, Seppo Vainio, Jingdong Shan, Sonia Sacco, Andreas Schedl, Constantine A. Stratakis, Antoine Martinez, Pierre Val
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WN
Externí odkaz:
https://doaj.org/article/47e9d947aff442c7b85b4848141ee1ea
Autor:
Sofia S. Pereira, Madalena M. Costa, Celso E. Gomez-Sanchez, Mariana P. Monteiro, Duarte Pignatelli
Publikováno v:
Biomedicines, Vol 8, Iss 8, p 256 (2020)
Autonomous steroid secretion is a common feature of adrenocortical carcinomas (ACC), although not always clinically evident owing to inefficient steroidogenesis with increased release of steroid precursors. Our study aim was to analyze the expression
Externí odkaz:
https://doaj.org/article/d764966d59014e729e5f3e3285b43c83
Autor:
Nae Takizawa, Susumu Tanaka, Koshiro Nishimoto, Yuki Sugiura, Makoto Suematsu, Chisato Ohe, Haruyuki Ohsugi, Yosuke Mizuno, Kuniaki Mukai, Tsugio Seki, Kenji Oki, Celso E. Gomez-Sanchez, Tadashi Matsuda
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 10, Pp 128-138 (2022)
Primary aldosteronism is most often caused by aldosterone-producing adenoma (APA) and bi-lateral adrenal hyperplasia. Most APAs are caused by somatic mutations of various ion channels and pumps, the most common being the inward-rectifying potassium c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4664b85cac528510d25f4967f4234a
https://www.mdpi.com/1467-3045/44/1/10
https://www.mdpi.com/1467-3045/44/1/10
Autor:
Takaya Kodama, Kenji Oki, Yu Otagaki, Ryuta Baba, Akira Okada, Kiyotaka Itcho, Kazuhiro Kobuke, Gaku Nagano, Haruya Ohno, Nobuyuki Hinata, Koji Arihiro, Celso E Gomez-Sanchez, Masayasu Yoneda, Noboru Hattori
Publikováno v:
Endocrine-Related Cancer. 29:495-502
DNA methylation and demethylation regulate the transcription of genes. DNA methylation-associated gene expression of adrenal steroidogenic enzymes may regulate cortisol production in cortisol-producing adenoma (CPA). We aimed to determine the DNA met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a0abbb1e681c45dc3c262fb79af2c7
https://doi.org/10.1530/erc-22-0115
https://doi.org/10.1530/erc-22-0115