Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Celso A Reis"'
Autor:
Nuno Brito Santos, Zoé Enderlin Vaz da Silva, Catarina Gomes, Celso A Reis, Maria João Amorim
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009381 (2021)
Clearance of viral infections, such as SARS-CoV-2 and influenza A virus (IAV), must be fine-tuned to eliminate the pathogen without causing immunopathology. As such, an aggressive initial innate immune response favors the host in contrast to a detrim
Externí odkaz:
https://doaj.org/article/526c994aa22a4396acc639f63657c52a
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0248257 (2021)
Phenylethyl isothiocyanate (PEITC), a chemopreventive compound, is highly reactive due to its considerably electrophilic nature. Furthermore, it is hydrophobic and has low stability, bioavailability and bioaccessibility. This restricts its use in bio
Externí odkaz:
https://doaj.org/article/27f75f8dcae149faa29be209bcb2d237
Autor:
Daniel Schnepf, Pedro Hernandez, Tanel Mahlakõiv, Stefania Crotta, Meagan E Sullender, Stefan T Peterson, Annette Ohnemus, Camille Michiels, Ian Gentle, Laure Dumoutier, Celso A Reis, Andreas Diefenbach, Andreas Wack, Megan T Baldridge, Peter Staeheli
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0247738 (2021)
The commensal microbiota regulates susceptibility to enteric pathogens by fine-tuning mucosal innate immune responses, but how susceptibility to enteric viruses is shaped by the microbiota remains incompletely understood. Past reports have indicated
Externí odkaz:
https://doaj.org/article/d68b02450db24632b3ba2774fe30dfac
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Pancreatic cancer (PC) is the sixth leading cause of cancer-related deaths worldwide, primarily due to late-stage diagnosis and limited treatment options. While novel biomarkers and immunotherapies are promising, further research into specific molecu
Externí odkaz:
https://doaj.org/article/bcff96ad2bde45a7921079a1af7bcb87
Autor:
Joana T de Oliveira, Ana L Santos, Catarina Gomes, Rita Barros, Cláudia Ribeiro, Nuno Mendes, Augusto J de Matos, M Helena Vasconcelos, Maria José Oliveira, Celso A Reis, Fátima Gärtner
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121590 (2015)
Oseltamivir phosphate is a widely used anti-influenza sialidase inhibitor. Sialylation, governed by sialyltransferases and sialidases, is strongly implicated in the oncogenesis and progression of breast cancer. In this study we evaluated the biologic
Externí odkaz:
https://doaj.org/article/3654178e8cc349989027097635bdc4cc
Autor:
Joana T de Oliveira, Cláudia Ribeiro, Rita Barros, Catarina Gomes, Augusto J de Matos, Celso A Reis, Gerard R Rutteman, Fátima Gärtner
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134458 (2015)
The tumor microenvironment encompasses several stressful conditions for cancer cells such as hypoxia, oxidative stress and pH alterations. Galectin-3, a well-studied member of the beta-galactoside-binding animal family of lectins has been implicated
Externí odkaz:
https://doaj.org/article/8905a6e1553b4af4bcb526c5299b9f84
Autor:
Sònia Bassagañas, Sandra Carvalho, Ana M Dias, Marta Pérez-Garay, M Rosa Ortiz, Joan Figueras, Celso A Reis, Salomé S Pinho, Rosa Peracaula
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98595 (2014)
In our previous studies we have described that ST3Gal III transfected pancreatic adenocarcinoma Capan-1 and MDAPanc-28 cells show increased membrane expression levels of sialyl-Lewis x (SLe(x)) along with a concomitant decrease in α2,6-sialic acid c
Externí odkaz:
https://doaj.org/article/b1eee55afa24460d995056ba3a32e117
Autor:
Catarina Gomes, Hugo Osório, Marta Teixeira Pinto, Diana Campos, Maria José Oliveira, Celso A Reis
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66737 (2013)
Sialyl-Lewis X (SLe(x)) is a sialylated glycan antigen expressed on the cell surface during malignant cell transformation and is associated with cancer progression and poor prognosis. The increased expression of sialylated glycans is associated with
Externí odkaz:
https://doaj.org/article/d472e14c9b00471c82434915f06d56fe
Autor:
Julio Cesar Madureira de-Freitas-Junior, Sandra Carvalho, Ana M Dias, Patrícia Oliveira, Joana Cabral, Raquel Seruca, Carla Oliveira, José Andrés Morgado-Díaz, Celso A Reis, Salomé S Pinho
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81579 (2013)
Changes in glycosylation are considered a hallmark of cancer, and one of the key targets of glycosylation modifications is E-cadherin. We and others have previously demonstrated that E-cadherin has a role in the regulation of bisecting GlcNAc N-glyca
Externí odkaz:
https://doaj.org/article/37ea24ae4fd841eba4782d7feab6bbff
Autor:
Joana Gomes, Ana Magalhães, Ana S Carvalho, Gilberto E Hernandez, Suzanne L Papp, Steven R Head, Valérie Michel, Leonor David, Fátima Gärtner, Eliette Touati, Celso A Reis
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38353 (2012)
The bracken fern Pteridium aquilinum is a plant known to be carcinogenic to animals. Epidemiological studies have shown an association between bracken fern exposure and gastric cancer development in humans. The biological effects of exposure to this
Externí odkaz:
https://doaj.org/article/8ccd1a12d67d43c1b76e26e06b248b28