Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Celsey M. St. Onge"'
Publikováno v:
Molecules, Vol 29, Iss 14, p 3331 (2024)
We recently developed a series of nalfurafine analogs (TK10, TK33, and TK35) that may serve as non-addictive candidate analgesics. These compounds are mixed-action agonists at the kappa and delta opioid receptors (KOR and DOR, respectively) and produ
Externí odkaz:
https://doaj.org/article/3bd22c861a0e4555aaa74314112260cd
Publikováno v:
Pharmacology, biochemistry, and behavior. 221
Recent studies have shown that social interaction can serve as an alternative reinforcer to opioid self-administration under a choice context in rats. However, additional parametric studies are needed to evaluate the sensitivity of opioid-vs.-social
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a991ddcac9c7237e3d71d23a529a42
https://pubmed.ncbi.nlm.nih.gov/36228740
https://pubmed.ncbi.nlm.nih.gov/36228740
Publikováno v:
Journal of molecular graphicsmodelling. 116
Lysophosphatidic acid receptor 4 (LPA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f077671730b8d684c881226fdc43f1f7
https://pubmed.ncbi.nlm.nih.gov/35868118
https://pubmed.ncbi.nlm.nih.gov/35868118
Publikováno v:
Tetrahedron Lett
Methodology is presented for the synthesis of 6α/β−3-dehydroxynaltrexamines and 6α/β-N-methyl-3-dehydroxynaltrexamines. A stereoselective route is provided for each target compound while a novel one-pot method for the synthesis of 6α/β−3-N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f43b6a6f17937a49c2993acbbc17c653
https://pubmed.ncbi.nlm.nih.gov/33100417
https://pubmed.ncbi.nlm.nih.gov/33100417
Publikováno v:
Drug Discov Today
G protein-coupled receptors (GPCRs) have been exploited as primary targets for drug discovery, and GPCR dimerization offers opportunities for drug design and disease treatment. An important strategy for targeting putative GPCR dimers is the use of bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38198b83c31107102644fe1cb6156608
https://pubmed.ncbi.nlm.nih.gov/33075471
https://pubmed.ncbi.nlm.nih.gov/33075471
Publikováno v:
Tetrahedron Letters. 61:152379
Methodology is presented for the synthesis of 6α/β-3-dehydroxynaltrexamines and 6α/β-N-methyl-3-dehydroxynaltrexamines. A stereoselective route is provided for each target compound while a novel one-pot method for the synthesis of 6α/β-N-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::444e58273d1b933c9a329c5d4966290d
https://doi.org/10.1016/j.tetlet.2020.152379
https://doi.org/10.1016/j.tetlet.2020.152379